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Keywords: Nuclear lamina
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Journal Articles
J Cell Sci (2021) 134 (17): jcs247171.
Published: 9 September 2021
...Takanobu Moriuchi; Fumiko Hirose ABSTRACT Dephosphorylation of lamin A, which triggers nuclear lamina reconstitution, is crucial for the completion of mitosis. However, the specific phosphatase and regulatory mechanism that allow timely lamin A dephosphorylation remain unclear. Here, we report...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs246330.
Published: 24 June 2020
...Shivnarayan Dhuppar; Aprotim Mazumder ABSTRACT Nuclear architecture is the organization of the genome within a cell nucleus with respect to different nuclear landmarks such as the nuclear lamina, nuclear matrix or nucleoli. Recently, nuclear architecture has emerged as a major regulator of gene...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs240416.
Published: 27 May 2020
... proteins’ that function to bridge heterochromatin and the nuclear membrane or nuclear lamina. We previously identified a human tethering protein, PRR14, that binds heterochromatin through an N-terminal domain, but the mechanism and regulation of nuclear lamina association remained to be investigated. Here...
Includes: Supplementary data
Journal Articles
In collection:
J Cell Sci (2017) 130 (14): 2243–2250.
Published: 15 July 2017
... cytoskeleton, nuclear lamina and chromatin are critical for cellular responses and adaptation to external mechanical cues. In that respect, dynamic changes in the nuclear lamina and the surrounding cytoskeleton modify mechanical properties of the nucleus, thereby protecting genetic material from damage...
Journal Articles
J Cell Sci (2017) 130 (13): 2111–2118.
Published: 1 July 2017
...; but how cells sense and transduce mechanical cues to modulate SRF−Mkl1-dependent gene expression is not well understood. Here, we demonstrate that the nuclear lamina-associated inner nuclear membrane protein Emerin stimulates SRF−Mkl1-dependent gene activity in a substrate stiffness-dependent manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3956–3969.
Published: 15 September 2014
...Jason M. Berk; Dan N. Simon; Clifton R. Jenkins-Houk; Jason W. Westerbeck; Line M. Grønning-Wang; Cathrine R. Carlson; Katherine L. Wilson ABSTRACT Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4253–4266.
Published: 15 December 2011
...) was then detected by western blotting using a mouse monoclonal antibody against the analogue ( Troutman et al., 2005 ). Electron tomography Nuclear lamina Nucleoplasmic reticulum The nuclear lamina is a proteinaceous mesh that underlies the nuclear envelope. It is involved in a diverse range...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 401–413.
Published: 1 February 2009
...-catenin and emerin influenced each other's levels of expression and the onset of adipogenesis, suggesting that changes in the expression of nuclear lamina proteins were intimately linked to the stability of β-catenin. By contrast, dermal fibroblasts, which are emerin null, demonstrated increased nuclear...
Journal Articles
J Cell Sci (2008) 121 (24): 4018–4028.
Published: 15 December 2008
... structures of the nuclear lamina were formed in senescent hMSCs, which are identified by the presence of Hayflick-senescence-associated factors. Notably, spatial changes in lamina shape were observed before the Hayflick senescence-associated factors, suggesting that the lamina morphology can be used...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (2): 215–225.
Published: 15 January 2008
...Martin W. Goldberg; Irm Huttenlauch; Christopher J. Hutchison; Reimer Stick Lamins are intermediate filament proteins and the major component of the nuclear lamina. Current views of the lamina are based on the remarkably regular arrangement of lamin LIII in amphibian oocyte nuclei. We have re...
Journal Articles
J Cell Sci (2007) 120 (14): 2344–2351.
Published: 15 July 2007
... are often more prominent along the nuclear periphery (reviewed by McNairn and Gilbert, 2003 ; Misteli, 2004 ). Nuclear lamina proteins are essential for viability of cells and whole organisms, and play an important role in the positioning of genes and chromosomes at the nuclear envelope (reviewed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2704–2714.
Published: 1 July 2006
...Kaliyaperumal Manju; Bhattiprolu Muralikrishna; Veena K Parnaik A-type lamins are components of the nuclear lamina. Mutations in the gene encoding lamin A are associated with a range of highly degenerative diseases termed laminopathies. To evaluate sensitivity to DNA damage, GFP-tagged lamin...
Journal Articles
J Cell Sci (2005) 118 (21): 5079–5087.
Published: 1 November 2005
... and lamina morphology were abnormal in JIL-1 mutant egg chambers. The most common phenotypes observed were abnormal nurse cell nuclear lamina protrusions through the ring canals near the oocyte, as well as dispersed and mislocalized lamin throughout the egg chamber. These phenotypes were completely rescued...
Journal Articles
J Cell Sci (2004) 117 (20): 4779–4786.
Published: 15 September 2004
... a network elastic modulus, unaffected by nucleoplasm, that averages 25 mN/m. Compared to plasma membranes of cells, the nuclear envelope is much stiffer and more resilient. Our results suggest that the nuclear lamina forms a compressed network shell of interconnected rods that is extensible but limited...
Journal Articles
J Cell Sci (2003) 116 (14): 3027–3035.
Published: 15 July 2003
... and R386K). Because L85R specifically affects lamin C assembly ( Raharjo et al.,2001 ), we could say that all five rod mutations cause defective assembly of the nuclear lamina. Because most or all of these rod mutations cause lamin A to accumulate in intranuclear foci in about 10% of cells, we...
Journal Articles
J Cell Sci (2003) 116 (10): 2067–2072.
Published: 15 May 2003
...Shobana S. Mani; Rithwick Rajagopal; Amanda B. Garfinkel; Xiaochun Fan; Mariana F. Wolfner The nuclear lamina provides an architectural framework for the nuclear envelope and an attachment site for interphase chromatin. In Drosophila eggs and early embryos its major constituent, lamin Dm 0...
Journal Articles
J Cell Sci (2001) 114 (24): 4567–4573.
Published: 15 December 2001
... al., 1994 ) or LMNA ( Bonne et al., 1999 ), which encode nuclear lamina proteins named emerin and A-type lamins, respectively ( Cohen et al., 2001 ). Mutations in LMNA can also give rise to other diseases ( Bonne et al., 2000 ), including dilated cardiomyopathy and lipodystrophy. The mechanisms...
Journal Articles
J Cell Sci (2001) 114 (22): 4001–4011.
Published: 15 November 2001
... ) 3 8 2001 © The Company of Biologists Limited 2001 2001 Nuclear lamina Lamin A Muscle differentiation Myoblasts The lamins form a network of filaments underlying the inner nuclear membrane termed the nuclear lamina. The lamina is considered to be an important determinant...
Journal Articles
J Cell Sci (2001) 114 (20): 3643–3653.
Published: 15 October 2001
... TUNEL assay and completed before clustering of the nuclear pores. POM121 was eliminated significantly more rapid compared with NUP153 (a peripheral protein located in the nucleoplasmic basket of the nuclear pore complex) and lamin B (a component of the nuclear lamina). Disappearance of NUP153 and lamin...
Journal Articles
J Cell Sci (2001) 114 (14): 2577–2590.
Published: 15 July 2001
... within the ER. Our data suggest that lamin A is essential for anchorage of emerin to the inner nuclear membrane and of lamin C to the lamina. 14 4 2001 © The Company of Biologists Limited 2001 2001 Lamins Emerin Nuclear envelope Nuclear lamina Emery-Dreifuss muscular dystrophy...