... glutamatergic neuromuscular junction (NMJ) as a model synapse for understanding extracellular roles of the many heparan sulfate proteoglycan (HSPG) and lectin proteins that help determine synaptic architecture and neurotransmission strength. We particularly concentrate on the roles of extracellular HSPGs...

... homolog SH3PX1 in Drosophila reveals a new role in the development of presynaptic active zones and regulation of neurotransmitter release. Synaptogenesis Neurotransmission Drosophila neuromuscular junction Nervous wreck Sorting nexin Synapse formation and function are crucial...

... at the membrane on both sides of the synaptic interface. We show that LGL has a cell autonomous presynaptic role facilitating NMJ terminal branching and synaptic bouton formation. Moreover, loss of both pre- and postsynaptic LGL strongly decreases evoked neurotransmission strength, whereas the frequency...

... determined the sensitivity of autaptic EPSCs to baclofen treatment, which gave similar effects to those from the fEPSP recordings in hippocampal slices ( Fig. 1B ). Next, we applied pulses of baclofen (30 μM) to investigate the kinetics of the GABA B R effect on neurotransmission ( Fig. 1C ). A reduction...

... structural architecture, with decreased terminal arbor size, branching and synaptic bouton number. Functionally, loss of Smg1 results in a ~50% reduction in basal neurotransmission strength, as well as progressive transmission fatigue and greatly impaired synaptic vesicle recycling during high-frequency...