... effector proteins that reduce RNA polymerase II activity on genes required for neurogenesis. miR-26b regulates neurogenesis in zebrafish by targeting ctdsp2 mRNA, but the molecular events triggered by this microRNA (miR) remain unknown. Here, we show in a murine embryonic stem cell differentiation paradigm...

... the polarizing elements, ZO-1, PARD3 and β-catenin during polarization and lumen production for neural rosette formation. We further demonstrate that the dismantlement of neural rosettes, mediated by the destruction of cytoskeletal elements, promotes neurogenesis and astrogenesis prematurely, indicating...

.... In this context, published results indicate that bradykinin functions in neural fate determination, favoring neurogenesis and migration. However, mechanisms underlying bradykinin function are yet to be explored. Our findings indicate a previously unidentified role for bradykinin action in inducing neuron...

... contributing to the increased differentiation of NSCs into granule cells. These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult. Estimation of perisomatic...

... their transcriptional targets. Here we performed in vivo and in silico experiments to study how such cooperativity and antagonism might function during neurogenesis. In vivo electroporation experiments in the chick embryo neural tube show that Smad2 and Smad3 cooperate to promote neurogenesis, as well...

.... Dev. Biol.   205 , 232 – 242 . 10.1007/BF00365801 Galliot   B. , Quiquand   M. , Ghila   L. , de Rosa   R. , Miljkovic-Licina   M. , Chera   S. ( 2009 ). Origins of neurogenesis, a cnidarian view.   Dev. Biol.   332 , 2 – 24 . 10.1016/j.ydbio.2009.05.563 Grens...

... neurogenesis. As WDR62 is a multi-functional protein with dynamic intracellular distribution dependent on cellular context, this raises the significant question of the range of regulatory mechanisms for its actions. Our study has now provided first insights into the mechanisms that regulate mitotic...

... NPCs, which are positive for neural progenitor cell marker (Pax6) but negative for glial cell marker (glial fibrillary acidic protein; GFAP), is reduced within a few days in culture following knockdown of these molecules, suggesting that Ror1, Ror2 and Wnt5a regulate neurogenesis through...

... and contributed equally to this work ‡ Authors for correspondence ( avoss@wehi.edu.au ; tthomas@wehi.edu.au ) 22 7 2011 © 2012. 2012 MYST Epigenetics Neurogenesis Neural stem cells HAT Histone acetyltransferase Fluorescence-activated cell sorting Polycomb Adult neural stem...

... for Chst14 resulted in decreased neurogenesis and diminished proliferation of NSCs accompanied by increased expression of GLAST and decreased expression of Mash-1, and an upregulation of the expression of the receptors for fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). By contrast...

...Ya-Zhou Wang; Takashi Yamagami; Qini Gan; Yongping Wang; Tianyu Zhao; Salaheddin Hamad; Paul Lott; Nikolai Schnittke; James E. Schwob; Chengji J. Zhou The mammalian olfactory epithelium (OE) has a unique stem cell or progenitor niche, which is responsible for the constant peripheral neurogenesis...

...Ivette Grimm; Nanette Messemer; Matthias Stanke; Christian Gachet; Herbert Zimmermann The adult subventricular zone (SVZ) contains astrocyte-like stem cells capable of generating new neurons for the olfactory bulb. Adult neurogenesis is driven by a variety of signal systems that can induce...

... Bridge, London, SE1 9RT, UK 15 7 2008 © The Company of Biologists Limited 2008 2008 Brain size Cerebral cortex Neural stem and progenitor cells Neurogenesis Radial glia Symmetric and asymmetric cell division One of the most fascinating topics in biology is the increase...

...Elisabetta Ciani; Vincenzo Calvanese; Christophe Crochemore; Renata Bartesaghi; Antonio Contestabile The diffusible messenger, nitric oxide plays multiple roles in neuroprotection, neurodegeneration and brain plasticity. Its involvement in neurogenesis has been disputed, on the basis of results...

..., several studies suggested that oxygen-dependent gene expression is of crucial importance in governing the essential steps of neurogenesis such as cell proliferation, survival and differentiation. In this context, we analysed the effect of the HIF-1 (hypoxia inducible factor-1) activation-mimicking agent...

... of the hypothetical role of the nELAV RBPs during neurogenesis. In the temporal sequence of events that lead a proliferating NSC to become a differentiated neuron, Msi1 and nELAV RNA-binding activities are complementary and exert a different function on their target mRNAs. nELAV stabilization of the Msi1 transcript...

...-mail: ruth.williams@csc.mrc.ac.uk ; amanda.fisher@csc.mrc.ac.uk ) 4 10 2005 © The Company of Biologists Limited 2006 2006 Chromatin Transcription Replication timing Nuclear organization Neurogenesis Epigenetics Proneural Mash1 (Ascl1) is a key transcription factor essential during...

... 2005 2005 Bone-marrow-derived stem cells Neurogenesis Transdifferentiation The notion that phenotypic fate is indissolubly bound to the embryonic germ layer derivation of the cell has been challenged by several observations on different types of pluripotent stem cells. A number...

... 2004 nNOS Neuroblastoma cells Cerebellar granule cells Development N-Myc Neurogenesis New functions played by nitric oxide (NO) as an intercellular and intracellular signaling molecule in the brain are continuously demonstrated and increasing evidence suggests that NO might...

... of Biologists Limited 2004 2004 Stem cells Aging Bone marrow Pluripotential Reparative medicine Neurogenesis We have isolated a unique subpopulation of human marrow stromal cells capable of differentiating in vitro into cell lineages derived from all three germ layers. Marrow stromal cells...