... effector proteins that reduce RNA polymerase II activity on genes required for neurogenesis. miR-26b regulates neurogenesis in zebrafish by targeting ctdsp2 mRNA, but the molecular events triggered by this microRNA (miR) remain unknown. Here, we show in a murine embryonic stem cell differentiation paradigm...

... the polarizing elements, ZO-1, PARD3 and β-catenin during polarization and lumen production for neural rosette formation. We further demonstrate that the dismantlement of neural rosettes, mediated by the destruction of cytoskeletal elements, promotes neurogenesis and astrogenesis prematurely, indicating...

.... In this context, published results indicate that bradykinin functions in neural fate determination, favoring neurogenesis and migration. However, mechanisms underlying bradykinin function are yet to be explored. Our findings indicate a previously unidentified role for bradykinin action in inducing neuron...

... contributing to the increased differentiation of NSCs into granule cells. These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult. The ability of neural stem...

... their transcriptional targets. Here we performed in vivo and in silico experiments to study how such cooperativity and antagonism might function during neurogenesis. In vivo electroporation experiments in the chick embryo neural tube show that Smad2 and Smad3 cooperate to promote neurogenesis, as well...

.... , Quiquand   M. , Ghila   L. , de Rosa   R. , Miljkovic-Licina   M. , Chera   S. ( 2009 ). Origins of neurogenesis, a cnidarian view.   Dev. Biol.   332 , 2 – 24 . 10.1016/j.ydbio.2009.05.563 Grens   A. , Mason   E. , Marsh   J. L. , Bode   H. R. ( 1995 ). Evolutionary...

... neurogenesis. * Author for correspondence ( ngd@unimelb.edu.au ) 4 7 2012 © 2012. Published by The Company of Biologists Ltd 2012 Centrosome Spindle pole WD-repeat proteins Mitosis Cell division Neurogenesis The bipolar spindle is a highly organized microtubule-based...

... NPCs, which are positive for neural progenitor cell marker (Pax6) but negative for glial cell marker (glial fibrillary acidic protein; GFAP), is reduced within a few days in culture following knockdown of these molecules, suggesting that Ror1, Ror2 and Wnt5a regulate neurogenesis through...

... lineage characteristics including the epigenetic mechanisms that regulate NSC self-renewal and lineage commitment in adult neurogenesis. The Qkf–GFP BAC construct used for the generation of transgenic mice was generated by homologous recombination in Escherichia coli using the method...

... for Chst14 resulted in decreased neurogenesis and diminished proliferation of NSCs accompanied by increased expression of GLAST and decreased expression of Mash-1, and an upregulation of the expression of the receptors for fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). By contrast...

...Ya-Zhou Wang; Takashi Yamagami; Qini Gan; Yongping Wang; Tianyu Zhao; Salaheddin Hamad; Paul Lott; Nikolai Schnittke; James E. Schwob; Chengji J. Zhou The mammalian olfactory epithelium (OE) has a unique stem cell or progenitor niche, which is responsible for the constant peripheral neurogenesis...

...Ivette Grimm; Nanette Messemer; Matthias Stanke; Christian Gachet; Herbert Zimmermann The adult subventricular zone (SVZ) contains astrocyte-like stem cells capable of generating new neurons for the olfactory bulb. Adult neurogenesis is driven by a variety of signal systems that can induce...

... Bridge, London, SE1 9RT, UK 15 7 2008 © The Company of Biologists Limited 2008 2008 Brain size Cerebral cortex Neural stem and progenitor cells Neurogenesis Radial glia Symmetric and asymmetric cell division One of the most fascinating topics in biology is the increase...

...Elisabetta Ciani; Vincenzo Calvanese; Christophe Crochemore; Renata Bartesaghi; Antonio Contestabile The diffusible messenger, nitric oxide plays multiple roles in neuroprotection, neurodegeneration and brain plasticity. Its involvement in neurogenesis has been disputed, on the basis of results...

..., several studies suggested that oxygen-dependent gene expression is of crucial importance in governing the essential steps of neurogenesis such as cell proliferation, survival and differentiation. In this context, we analysed the effect of the HIF-1 (hypoxia inducible factor-1) activation-mimicking agent...

... Musashi-1 Neurogenesis RNA-binding protein Stem cell In mammals, adult neurogenesis was demonstrated to be active in two main brain regions, namely the subventricular zone (SVZ) and the dentate gyrus of the hippocampus, where neural stem cells (NSCs) were isolated ( Alvarez-Buylla and Garcia...

... commitment and confirms that transcriptional status of certain genes is independent of position relative to the nuclear periphery ( Pah, Igf1, Nup37 ). Interestingly, a similar analysis of two unlinked genes: Neurod (involved in neurogenesis, located on chromosome 2C3) and Sprr2a (involved in epidermal...

... 2005 2005 Bone-marrow-derived stem cells Neurogenesis Transdifferentiation The notion that phenotypic fate is indissolubly bound to the embryonic germ layer derivation of the cell has been challenged by several observations on different types of pluripotent stem cells. A number...

...-Myc expression. The similarity with what has been demonstrated for precursors of granule neurons of the dentate gyrus, whose proliferation rate is increased by NOS inhibitor in adult mice ( Cheng et al., 2003 ; Packer et al., 2003 ), allow us to hypothesize a role for NO in cerebellar neurogenesis...

... demonstrate specific and clear differences among these pluripotent subpopulations of cells. Stem cells Aging Bone marrow Pluripotential Reparative medicine Neurogenesis © The Company of Biologists Limited 2004 2004 14 1 2004 * Author for correspondence (e-mail: p.schiller...