...-deficient mice. We showed that Fhl2 is expressed in neural stem cells, precursors and mature cells of neuronal lineage. Moreover, Fhl2 deficiency leads to delayed neuroblast migration in vivo , premature astroglial differentiation of neural stem cells (NSCs) in vitro , and a gliosis-like accumulation...

... Astrocytes Neural stem cells Alternative splicing Epigenetics GFAP isoforms In the adult mammalian brain, astrocytes represent the major population of glial cells. Astrocytes are crucial for neuronal support, including synaptic transmission and information processing by neural circuits...

... stained with antibodies against TNR (red) and Ki67 (green). Note the expression of TNR (red dots) in the neurogenic area of the hippocampus containing Ki67 + neural stem cells (NSCs). Scale bar: 20 µm. (E) Western blot analysis of lysates of the hippocampus of mice at E16, E18, P0, P7, P15 and P90...

... Paré 75475 Paris cedex, 10, France ‡ These authors contributed equally to this work § Author for correspondence ( cmartinat@istem.fr ) 4 01 2013 © 2013. Published by The Company of Biologists Ltd 2013 Neural stem cells Human embryonic stem cells Pathological modeling...

...Bilal N. Sheikh; Mathew P. Dixon; Tim Thomas; Anne K. Voss Adult neural stem cells (NSCs) reside in the subventricular zone (SVZ) and produce neurons throughout life. Although their regenerative potential has kindled much interest, few factors regulating NSCs in vivo are known. Among...

...Shan Bian; Nuray Akyüz; Christian Bernreuther; Gabriele Loers; Ewa Laczynska; Igor Jakovcevski; Melitta Schachner Chondroitin sulfates (CSs) and dermatan sulfates (DSs) are enriched in the microenvironment of neural stem cells (NSCs) during development and in the adult neurogenic niche, and have...

... belong to a signaling network that regulates neurogenesis. On the basis of previous data, we have identified Eph receptor A4 (EphA4) as a potential regulator of neurogenesis. We showed by immunohistochemistry that in adult neurogenic niches EphA4 is expressed only by neural stem cells (NSCs). Using...

...Matthew J. Birket; Adam L. Orr; Akos A. Gerencser; David T. Madden; Cathy Vitelli; Andrzej Swistowski; Martin D. Brand; Xianmin Zeng Here, we have investigated mitochondrial biology and energy metabolism in human embryonic stem cells (hESCs) and hESC-derived neural stem cells (NSCs). Although stem...

... in mammalian brain formation and neural stem cell (NSC) development. Here we show that Dicer plays a crucial role in controlling mouse cortical NSC development. We found that Dicer function is essential for expanding cortical neural progenitors and NSCs. We have identified a population of Dicer- deficient NSCs...

...Andreas Hermann; Regina Gastl; Stefan Liebau; M. Oana Popa; Jörg Fiedler; Bernhard O. Boehm; Martina Maisel; Holger Lerche; Johannes Schwarz; Rolf Brenner; Alexander Storch Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific...

..., an intermediate filament protein predominantly expressed by neural stem cells. Two factors contribute to the regulation of nestin expression by rat stromal cells: serum in the culture medium inhibits nestin expression and a threshold number of passages must be reached below which nestin expression does not occur...