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Keywords: Nek2
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Journal Articles
J Cell Sci (2014) 127 (11): 2493–2506.
Published: 1 June 2014
... disjunction and is triggered by the Nek2-dependent phosphorylation of C-Nap1. However, the mechanistic consequences of C-Nap1 phosphorylation are unknown. Here, we demonstrate that Nek2 phosphorylates multiple residues within the C-terminal domain of C-Nap1 and, collectively, these phosphorylation events lead...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 2106–2116.
Published: 15 June 2007
...Yeontae Jeong; Jungmin Lee; Kyeongmi Kim; Jae Cheal Yoo; Kunsoo Rhee Nek2 is a mitotic kinase whose activity varies during the cell cycle. It is well known that Nek2 is involved in centrosome splitting, and a number of studies have indicated that Nek2 is crucial for maintaining the integrity...
Journal Articles
J Cell Sci (2004) 117 (23): 5557–5566.
Published: 1 November 2004
...Seongkeun Sonn; Inkoo Khang; Kyungjin Kim; Kunsoo Rhee Nek2, a mammalian structural homologue of Aspergillus protein kinase NIMA, is predominantly known as a centrosomal kinase that controls centriole-centriole linkage during the cell cycle. However, its dynamic subcellular localization during...
Journal Articles
J Cell Sci (2002) 115 (16): 3275–3284.
Published: 15 August 2002
... protein kinase Nek2, as the formation of large C-Nap1 structures was substantially reduced upon co-expression of active Nek2. We conclude that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis. ‡ Author...
Journal Articles
J Cell Sci (2002) 115 (9): 1919–1929.
Published: 1 May 2002
...Ralph Gräf Dictyostelium Nek2 (DdNek2) is the first structural and functional non-vertebrate homologue of human Nek2, a NIMA-related serine/threonine kinase required for centrosome splitting in early mitosis. DdNek2 shares 43% overall amino-acid identity with its human counterpart and 54% identity...
Journal Articles
J Cell Sci (2001) 114 (20): 3749–3757.
Published: 15 October 2001
...Patrick Meraldi; Erich A. Nigg Centrosome cohesion and separation are regulated throughout the cell cycle, but the underlying mechanisms are not well understood. Since overexpression of a protein kinase, Nek2, is able to trigger centrosome splitting (the separation of parental centrioles), we have...