1-15 of 15
Keywords: NLS
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2023) 136 (12): jcs261096.
Published: 26 June 2023
... regulated by inhibitory phosphorylation by aurora A kinase ( Tsai et al., 2011 ). Phosphorylation of amino acids that are closely located to the NLS motif identified here reduced microtubule nucleation in spindles of cultured human cells and impaired mitotic progression. Moreover, augmin with phosphorylated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs251637.
Published: 26 February 2021
..., intracellular fluorescence and cellular fractionation-based subcellular localization analyses to identify the ARID1B nuclear localization signal (NLS). A cytoplasm-restricted ARID1B-NLS mutant was significantly compromised in its canonical transcription activation and tumor suppressive functions, as expected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs236158.
Published: 19 March 2020
... protein linked to proteasome nuclear localization. Here, we show that Sts1 contains a non-canonical bipartite nuclear localization signal (NLS) important for both nuclear localization of Sts1 itself and the proteasome. Sts1 binds the karyopherin-α import receptor (Srp1) stoichiometrically...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (1): 23–28.
Published: 1 January 2010
... inhibition of β-catenin ubiquitylation. In this report, we present evidence that cFLIP-L translocates into the nucleus, which could have a role in modulation of Wnt signaling. cFLIP-L has a functional bipartite nuclear localization signal (NLS) at the C-terminus. Wild-type cFLIP-L (wt-FLIP-L) localizes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1452–1460.
Published: 1 May 2009
... are imported into or exported out of the nucleus. Here we show that several importins mediate the nuclear import of the human Snail proteins and we identify a unique nuclear localization signal (NLS), recognized by all the importins, that has been conserved during the evolution of the Snail family. This NLS...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (25): 6143–6152.
Published: 1 December 2004
... the identification and characterization of a highly basic nuclear localization signal (NLS) in Kaiso. The functionality of this NLS was verified by its ability to target a heterologous β-galactosidase/green-fluorescent-protein fusion protein to nuclei. The mutation of one positively charged lysine to alanine...
Journal Articles
J Cell Sci (2004) 117 (24): 5923–5936.
Published: 15 November 2004
... Limited 2004 2004 CaM Nucleus Transport Calcium NLS Calmodulin (CaM) is a ubiquitous Ca 2+ -binding protein that exists as a monomer of 16.8 kDa and belongs to the EF-hand homolog family, which includes 160 different Ca 2+ binding proteins ( Persechini et al., 1989 ; Pruschy et al...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (5): 899–906.
Published: 1 March 2000
...Maria A. Marchetti; Christian Tschudi; Helen Kwon; Sandra L. Wolin; Elisabetta Ullu ABSTRACT In all eukaryotic organisms proteins are targeted to the nucleus via a receptor-mediated mechanism that requires a specific nuclear localization sequence (NLS) in the protein. Little is known about...
Journal Articles
J Cell Sci (1997) 110 (11): 1325–1331.
Published: 1 June 1997
...Robert A. Fridell; Ray Truant; Leigh Thorne; R. Edward Benson; Bryan R. Cullen ABSTRACT Heterogeneous nuclear ribonucleoprotein A1 contains a sequence, termed M9, that functions as a potent nuclear localization signal (NLS) yet bears no similarity to the welldefined basic class of NLSs. Here, we...
Journal Articles
J Cell Sci (1995) 108 (2): 545–555.
Published: 1 February 1995
... requires active transcription, is not mediated by a canonical nuclear localisation signal (NLS). To identify the determinants of A1 subcellular localisation we developed an expression vector for studying the localisation, in transiently transfected cells, of the different structural motifs of A1 fused...
Journal Articles
J Cell Sci (1993) 105 (3): 799–806.
Published: 1 July 1993
.... Instead, we propose that the protein uses a bipartite NLS to enter the nucleus and then accumulates within the nucleolus by virtue of binding to other nucleolar components (probably rRNA) via its RNP and GR domains. † Author for correspondence * Present address: German Cancer Research Center...