... , C.-H. , Yamaguchi , H. , Yang , N.-K. , Ding , Q. et al. ( 2012 ). Epithelial–mesenchymal transition induced by TNF-α requires NF-κB–mediated transcriptional upregulation of Twist1 . Cancer Res. 72 , 1290 . 10.1158/0008-5472.CAN-11-3123 Li , C.-W. , Xia , W...

...Thomas O'Loughlin; Antonina J. Kruppa; Andre L. R. Ribeiro; James R. Edgar; Abdulaziz Ghannam; Andrew M. Smith; Folma Buss ABSTRACT Optineurin (OPTN) is a multifunctional protein involved in autophagy and secretion, as well as nuclear factor κB (NF-κB) and IRF3 signalling, and OPTN mutations...

... in fruit fly models of chronic inflammation. Ectopic Toll/NF-κB and JAK/STAT signaling in mutant D. melanogaster results in overproliferation of hematopoietic blood progenitors resulting in the formation of granuloma-like tumors. Ectopic JAK-STAT signaling also leads to metabolic inflammation. We report...

... and activation of receptor-interacting serine/threonine-protein kinase 2 (RIP2; also known as RIPK2), and subsequent activation of NF-κB signaling and anti-apoptosis gene expression in B-lymphoproliferative cells. Furthermore, PAX5 is able to interact with RIP1 and RIP3, modulating both RIP1-mediated TNFR...

...Tiphaine Douanne; Julie Gavard; Nicolas Bidère ABSTRACT Antigen-receptor-mediated activation of lymphocytes relies on a signalosome comprising CARMA1 (also known as CARD11), BCL10 and MALT1 (the CBM complex). The CBM activates nuclear factor κB (NF-κB) transcription factors by recruiting...

...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression...

...Laiqun Zhang; Ken Blackwell; Lauren M. Workman; Katherine N. Gibson-Corley; Alicia K. Olivier; Gail A. Bishop; Hasem Habelhah ABSTRACT The role of TRAF2 and TRAF5 in TNFα-induced NF-κB activation has become complicated owing to the accumulation of conflicting data. Here, we report that 7-day-old...

... different taxa in vertebrates revealed several conserved regions in the TNF sequence. By screening overlapping peptides derived from human TNF to determine their role in three different TNF-induced processes – apoptosis, necrosis and NF-κB stimulation – we found that TNF conserved regions are mostly related...

... but not differentiation in C2C12 cells. Further investigation revealed that Igf1r , Insr , Ccnd2 and Ccne1 were directly targeted by miR-195 and miR-497 in myoblasts. In addition, we confirmed that miR-195 and miR-497, which shared the similar expression profiling, were negatively regulated by nuclear factor κB (NF-κB...

...Hadi Khalil; Noureddine Loukili; Alexandre Regamey; Alvaro Cuesta-Marban; Elettra Santori; Marcel Huber; Christian Widmann ABSTRACT The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB...

... transcriptional program and inhibits an erythroid transcriptional program. DLX4 also induced gene signatures that are associated with nuclear factor κB (NF-κB) signaling. The ability of DLX4 to promote megakaryocyte development at the expense of erythroid generation was diminished by blocking NF-κB activity...

...Bin Ma; Monika Fey; Michael O. Hottiger ABSTRACT The discovery of functional crosstalk between WNT and nuclear factor κB (NF-κB) signaling has established a more complex role for these two pathways in inflammation and cancer. However, the molecular mechanisms of the crosstalk and its biological...

... for correspondence ( carlos.ibanez@ki.se ) Competing interests The authors declare no competing or financial interests. 14 8 2014 16 2 2015 © 2015. Published by The Company of Biologists Ltd 2015 Cell death γ‐secretase Nerve growth factor NF‐κB Presenilin‐1 Primary...

... of the nuclear factor κB (NF-κB) pathway were identified, including the p50 and p65 (RelA) NF-κB subunits. We show that FAM21 interacts with these components and regulates NF-κB-dependent gene transcription at the level of p65 chromatin binding. We further demonstrate that FAM21 contains a functional monopartite...

... factor NF-κB. The epigenetic mechanism underlying LPS-induced pro-inflammatory transcription is not fully understood. Herein, we describe a role for myocardin-related transcription factor A (MRTF-A, also known as MKL1) in this process. MRTF-A overexpression enhanced NF-κB-dependent pro-inflammatory...

...Andrew O'Hara; James Simpson; Pierre Morin; Carolyn J. Loveridge; Ann C. Williams; Sonia M. Novo; Lesley A. Stark ABSTRACT Nucleolar sequestration of the RelA subunit of nuclear factor (NF)-κB is an important mechanism for regulating NF-κB transcriptional activity. Ubiquitylation, facilitated...

...-surface receptor of S5a has not been identified. In this study, we show that apoptotic THP-1 cells release endogenous S5a that binds to death receptor-6 (DR6, also known as TNFRSF1), which was identified as an orphan receptor, to induce THP-1 cells to differentiate. Furthermore, we found that the NF-κB...

...Ronny Haenold; Falk Weih; Karl-Heinz Herrmann; Karl-Friedrich Schmidt; Katja Krempler; Christian Engelmann; Klaus-Armin Nave; Jürgen R. Reichenbach; Sigrid Löwel; Otto W. Witte; Alexandra Kretz ABSTRACT NF-κB is dually involved in neurogenesis and brain pathology. Here, we addressed its role...

... no competing interests. © 2014. Published by The Company of Biologists Ltd 2014 CREB MyD88 NF-κB Toll-like receptor Inflammation Interleukin The interaction of components of bacterial and viral pathogens with Toll-like receptors (TLRs), or the activation of the receptors...

... was subsequently translocated to the nucleus as a p50/p50 homodimer. Knockdown of NF-κB p50 abolished the ability of RvD1 to suppress TNF-α expression and also to restore efferocytosis, suggesting that the replacement of p65/p50 with p50/p50 homodimer in the nucleus is crucial for RvD1-mediated stimulation...