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Keywords: Myosin II
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Journal Articles
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In collection:
Cell migration
J Cell Sci (2023) 136 (3): jcs260591.
Published: 2 February 2023
... and cell velocity, suggesting that these second messengers are upstream of the actomyosin and chemotactic migration. An acute increase in cGMPi concentration released from membrane-permeable caged cGMP induced a transient shuttle of myosin II between the cytosol and cell cortex, suggesting a direct link...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (7): jcs259648.
Published: 14 April 2022
... is generated in the cell cortex of cortexillin and myosin II. In multi-nucleate cells, these proteins decorate the entire cell cortex except circular zones around the centrosomes. Unilateral cleavage furrows are initiated at spaces free of microtubule asters and invade the cells along trails of cortexillin...
Includes: Supplementary data
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Mechanobiology
J Cell Sci (2019) 132 (17): jcs234476.
Published: 2 September 2019
... by a control system. Proteins, such as non-muscle myosin II, function as both sensors and actuators, which then link to scaffolding proteins, transcription factors and metabolic proteins to create feedback loops that generate the foundational mechanical properties of the cell and modulate cellular behaviors...
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (15): jcs228916.
Published: 8 August 2019
.... , Tee , Y.-H. , Thiagarajan , V. , Hersen , P. , Chew , T.-L. , Safran , S. A. , Zaidel-Bar , R. and Bershadsky , A. D. ( 2017 ). Long-range self-organization of cytoskeletal myosin II filament stacks . Nat. Cell Biol.   19 , 133 - 141 . 10.1038/ncb3466 Hundt...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs226704.
Published: 16 January 2019
.... This contractility controller includes myosin II motors, actin crosslinkers and protein scaffolds, which exhibit robust and cooperative mechanoaccumulation. However, the biochemical interactions and feedback mechanisms that drive the controller remain unknown. Here, we use a proteomics approach to identify direct...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (1): jcs205625.
Published: 4 January 2018
... of cytokinesis, actomyosin ring assembly and contraction requires the myosin II heavy chain Myo2p. Although myo2 -E1, a temperature-sensitive mutant defective in the upper 50 kDa domain of Myo2p, has been studied extensively, the molecular basis of the cytokinesis defect is not understood. Here, we isolate myo2...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (13): 2613–2624.
Published: 1 July 2016
... localisation results in defects in CAR morphology and constriction. We provide evidence that the myosin II protein Myp2 and the myosin V protein Myo51 play roles in recruiting TORC2 to the CAR. We show that Myp2 and TORC2 are co-dependent upon each other for their normal localisation to the cytokinetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2209–2217.
Published: 15 June 2015
... by The Company of Biologists Ltd 2015 Summary: A systematic analysis of the non-muscle myosin II literature reveals the multitude of cellular processes in which contractility plays a role and the complex protein interaction network regulating it. Contractility Myosin II Non-muscle cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 50–60.
Published: 1 January 2015
...Arkadi Manukyan; Kirsten Ludwig; Sergio Sanchez-Manchinelly; Sarah J. Parsons; P. Todd Stukenberg ABSTRACT The cytokinetic furrow is organized by the RhoA GTPase, which recruits actin and myosin II to the furrow and drives contractility. Here, we show that the RhoA GTPase-activting protein (GAP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2542–2553.
Published: 1 June 2014
... these cell behaviors. Molecular marker analysis documented defects in myosin II light chain (MLC) phosphorylation, Rab11 and F-actin accumulation in GEF-H1-depleted cells. In gain-of-function studies, overexpressed GEF-H1 induced Rho-associated kinase-dependent ectopic apical constriction – marked by apical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 927–938.
Published: 15 February 2013
... remain confined within the limits of their source epithelium, permitting survival of the host animal. Through interaction with the myosin II heavy chain subunit, Cher is likely to strengthen the cortical actomyosin network and reinforce mechanical tension within the invasive tumors. Accordingly, Cher...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5790–5799.
Published: 1 December 2012
.... * Authors for correspondence ( kanderek@northwestern.edu ; grzybor@northwestern.edu ) 24 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Cell micropatterning Microtubules Myosin II Systems that search targets with high precision, such as smart missiles, often use...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3784–3796.
Published: 15 November 2011
.... In quiescent SCs, elevation of cAMP promotes the expression of proteins associated with myelination such as Krox-20 and P0, and downregulation of markers associated with the non-myelinating SC phenotype. We have previously shown that the motor protein myosin II is required for the establishment of normal SC...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1857–1866.
Published: 1 June 2011
... metalloproteinase (MT1-MMP) depends on adhesion, force generation and rigidity sensing of the cell. Melanoma cells (MV3 clone) stably transfected with MT1-MMP, or the empty vector as a control, served as the model system. α2β1 integrins (cell adhesion), actin and myosin II (force generation and rigidity sensing...
Journal Articles