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Keywords: Mitochondrial fission
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Journal Articles
J Cell Sci (2021) 134 (22): jcs258699.
Published: 19 November 2021
... compensate for the loss of endogenous Stx17. The quantitative data confirmed this notion ( Fig. 3 B). As Stx17 promotes mitochondrial fission by preventing Drp1 from being inactivated by PKA ( Arasaki et al., 2015 ) and by supporting Drp1 activation via protein phosphatase PGAM5 ( Sugo et al., 2018 ), we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs208603.
Published: 19 April 2018
... on lipid tubes, which sets it apart from other dynamins. Drp1 stabilizes mitochondrial curvature rather than being a membrane scissor. Dynamin-related protein 1 Membrane biophysics Protein self-assembly Membrane curvature Curvature stabilizer Mitochondrial fission Mitochondria...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (18): 2953–2960.
Published: 15 September 2017
.... Published by The Company of Biologists Ltd 2017 Summary: In this Review, we outline the machinery involved in mitochondrial fission including the recent discovery of Dnm2 as the final executor of membrane scission. An updated model of fission is presented. Finally, additional studies aimed...
Journal Articles
J Cell Sci (2017) 130 (4): 671–681.
Published: 15 February 2017
... for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development...
Journal Articles
J Cell Sci (2015) 128 (15): 2795–2804.
Published: 1 August 2015
...Kirstin D. Elgass; Elizabeth A. Smith; Mark A. LeGros; Carolyn A. Larabell; Michael T. Ryan ABSTRACT Mitochondrial fission is important for organelle transport, quality control and apoptosis. Changes to the fission process can result in a wide variety of neurological diseases. In mammals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4549–4560.
Published: 1 November 2014
...Anna L. Hatch; Pinar S. Gurel; Henry N. Higgs ABSTRACT Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial fission has received particular attention, owing to links...
Journal Articles
In collection:
Metabolism
J Cell Sci (2014) 127 (12): 2659–2671.
Published: 15 June 2014
... that treatment of cultured neonatal rat cardiomyocytes with the hypertrophic agonist norepinephrine promotes mitochondrial fission (characterized by a decrease in mitochondrial mean volume and an increase in the relative number of mitochondria per cell) and a decrease in mitochondrial function. We demonstrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5369–5376.
Published: 1 December 2013
... 2013 © 2013. Published by The Company of Biologists Ltd 2013 Fog Mitochondria Signaling Mitochondrial fusion Mitochondrial fission Cell shape and regulation of cell shape change play an important role in the organization of tissues and organ structures. During development...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3295–3304.
Published: 1 August 2013
...-dependent endocytosis of AMF, therefore, promotes Rac1-PI3K signaling that feeds back to promote AMF endocytosis and also inhibits the ability of Gp78 to target the mitofusins for degradation, thereby preventing Gp78-dependent mitochondrial fission. Through regulation of an ER-localized ubiquitin ligase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2924–2930.
Published: 1 July 2013
... outer membrane. Expression of chimeric plasma membrane tethers rescued mitochondrial fission defects in Δ num1 and Δ mdm36 mutants. These findings provide new insights into the coupling of mitochondrial dynamics, immobilization, and retention during inheritance. * Author for correspondence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 789–802.
Published: 1 February 2013
...Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen Summary Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could provide important research tools in addition to potential leads for drug...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5745–5757.
Published: 1 December 2012
...Wei Qian; Serah Choi; Gregory A. Gibson; Simon C. Watkins; Christopher J. Bakkenist; Bennett Van Houten Summary Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2402–2412.
Published: 15 July 2009
... of mitochondrial DNA. To address the mode of action of Lga2, we investigated its Dnm1 (a dynamin-related protein)-dependent effects. Here, we demonstrate that Dnm1 functions as a mitochondrial fission component in U. maydis and mediates Lga2-induced mitochondrial fragmentation. Mitochondrial fusion occurred very...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (13): 2252–2262.
Published: 1 July 2009
... with no effect on apoptosis. MTGM-induced mitochondrial fission can be blocked by a dominant negative Drp1 mutant (Drp1-K38A). Overexpression of MTGM also results in inhibition of cell proliferation, stalling of cells in S phase and nuclear accumulation of γ-H2AX. Knockdown of MTGM by RNA interference induces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (7): 1178–1188.
Published: 1 April 2007
...Rodolfo Zunino; Astrid Schauss; Peter Rippstein; Miguel Andrade-Navarro; Heidi M. McBride Mitochondria are dynamic organelles that undergo regulated fission and fusion events that are essential to maintain metabolic stability. We previously demonstrated that the mitochondrial fission GTPase DRP1...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4913–4925.
Published: 1 December 2006
...-containing primer (sequences will be provided on request). The amplified fragments were subcloned into Eco RI- Bam HI digested p3xFLAG-CMV14 vector. Mitochondria Mitochondrial fusion Mitochondrial fission Mitofusin proteins Mitochondria are extremely dynamic organelles...
Journal Articles
J Cell Sci (2006) 119 (15): 3098–3106.
Published: 1 August 2006
... in the mitochondrial fission process. We conclude that in wt cells approximately 50% of the Dnm1p pool is assembled on mitochondria. Fis1p and Caf4p are required to maintain this ratio between the cytosolic and the mitochondria-associated Dnm1p pool. In the following, we investigated the properties of more...
Includes: Supplementary data