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Keywords: Migration
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Journal Articles
J Cell Sci (2024) 137 (3): jcs261774.
Published: 12 February 2024
... in ARPC1B and show impaired migration and a switch from forming pseudopodia to forming elongated filopodia. We show, using a blood vessel on a chip model, that primary human neutrophils have impaired movement across an endothelium deficient in APRC1B. We also show that the combined deficiency of ARPC1B...
Includes: Supplementary data
Journal Articles
J Cell Sci jcs.261057.
Published: 7 February 2024
... in any medium provided that the original work is properly attributed. Growth cone Actin Migration Wellcome Trust https://dx.doi.org/10.13039/100010269 WT095829MA Cancer Research UK https://dx.doi.org/10.13039/501100000289 C6946/A14492 National Institute...
Journal Articles
J Cell Sci (2023) 136 (11): jcs260768.
Published: 8 June 2023
... been postulated that the unique segmented nucleus of neutrophils functions to assist their rapid migration. Here, we tested this hypothesis by imaging primary human neutrophils traversing narrow channels in custom-designed microfluidic devices. Individuals were given an intravenous low dose...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2023) 136 (6): jcs260373.
Published: 10 March 2023
... precursors and defective formation of growth cones in young neurons. Here, we present new evidence that upon Rac1 and Rac3 ablation, centrosome, Golgi complex and lysosome positioning is significantly perturbed, thus affecting both interneuron migration and axon growth. Moreover, for the first time, we...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2022) 135 (17): jcs259347.
Published: 13 September 2022
... focal adhesion disassembly. LL5β is phosphorylated by MINK1, promoting its interaction with CLASP proteins. Using a kinase inhibitor, we demonstrate that the enzymatic activity of MINK1 is involved in PRICKLE1–LL5β complex assembly and localization, as well as in cell migration. Analysis of gene...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (17): jcs259686.
Published: 7 September 2022
... to be recycled back to the cell membrane. We show that PDGFRβ homodimer activation results in a greater amplitude of phospho-ERK1/2 and phospho-AKT signaling, as well as increased proliferation and migration. Finally, we demonstrate that inhibition of clathrin-mediated endocytosis leads to changes in cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (12): jcs260272.
Published: 28 June 2022
... characterized, particularly during development . Although exosomes released by invasive metastatic cells alter migration of neighboring cells in culture, it is unclear whether cancer cells misappropriate exosomes released by healthy differentiated cells or reactivate dormant developmental programs that include...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
...Kristiane Søreng; Serhiy Pankiv; Camilla Bergsmark; Ellen M. Haugsten; Anette K. Dahl; Laura R. de la Ballina; Ai Yamamoto; Alf H. Lystad; Anne Simonsen ABSTRACT Cell migration is a complex process underlying physiological and pathological processes such as brain development and cancer metastasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs248294.
Published: 17 February 2021
... was maintained despite cells readily delaminating from epithelial sheets. Distinct from the prominent filopodia in p110α H1047R -expressing cells, p110β induced formation of lamellipodia, and these cells migrated with significantly greater velocity and decreased directionality. p110β-induced phenotypic...
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (17): jcs248328.
Published: 9 September 2020
...Nathan H. Roy; Sarah Hyun Ji Kim; Alexander Buffone, Jr; Daniel Blumenthal; Bonnie Huang; Sangya Agarwal; Pamela L. Schwartzberg; Daniel A. Hammer; Janis K. Burkhardt ABSTRACT T cell entry into inflamed tissue requires firm adhesion, cell spreading, and migration along and through the endothelial...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (7): jcs235762.
Published: 8 April 2020
... and the transmembrane heparan sulfate proteoglycan syndecan-4 in influencing adhesion, migration and angiogenesis. Knockdown of ADAMTS-1 in endothelial cells resulted in a parallel reduction in cell surface syndecan-4, attributable to increased matrix metalloproteinase-9 (MMP9) activity. Knockdown of either ADAMTS-1...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (5): jcs235275.
Published: 2 March 2020
...Daniel A. Girón-Pérez; Eduardo Vadillo; Michael Schnoor; Leopoldo Santos-Argumedo; Ana-Maria Lennon-Duménil ABSTRACT The inclusion of lymphocytes in high endothelial venules and their migration to the lymph nodes are critical steps in the immune response. Cell migration is regulated by the actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs234641.
Published: 21 January 2020
...-polarized hMDMs. Using PTPε-specific siRNAs and expression of RPTPε and cyt-PTPε, we found that RPTPε is involved in monocyte adhesion and migration of M2-polarized hMDMs in response to LTD 4 . Altered organization of podosomes and higher phosphorylation of the inhibitory Y-722 residue of ROCK2 was also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (23): jcs232637.
Published: 2 December 2019
...Kim Kenwrick; Amrita Mukherjee; Andrew D. Renault ABSTRACT During development, many cell types migrate along stereotyped routes determined through deployment of cell surface or secreted guidance molecules. Although we know the identity of many of these molecules, the distances over which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs234633.
Published: 23 September 2019
... and resulted in a thicker epidermal layer after reepithelialization. Conversely, preventing Cx43 phosphorylation by mitogen-activated protein kinases (MAPKs) through mutation significantly increased the rate of wound closure in vivo . Defects in migration, but not proliferation, in all mutants were partially...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs230680.
Published: 4 September 2019
... in Ahi1 −/− MEFs restored ciliary length, increased ciliary recruitment of Arl13b and augmented Arl13b stability. Finally, Ahi1 −/− MEFs displayed defects in cell motility and Pdgfr-α-dependent migration. Overall, our findings support molecular mechanisms underlying JBTS etiology that involve: (1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (15): jcs231241.
Published: 31 July 2019
... into integrin β4 dynamics in response to a migratory stimulus (scratch wound) by live-cell video microscopy. An increase in integrin β4 expression in cells proximal to the wound edge was evident, and a population of integrin β4-expressing cells that exhibited unusually rapid migration was identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225805.
Published: 5 April 2019
...Bertille Bance; Shailaja Seetharaman; Cécile Leduc; Batiste Boëda; Sandrine Etienne-Manneville ABSTRACT Microtubules play a crucial role in mesenchymal migration by controlling cell polarity and the turnover of cell adhesive structures on the extracellular matrix. The polarized functions...
Includes: Supplementary data
Journal Articles