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Keywords: Microtubules
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Journal Articles
J Cell Sci (2023) 136 (5): jcs259689.
Published: 16 November 2022
... endosomal choreography, which includes bidirectional and stop-and-go motions, is coordinated by the microtubule-based motor proteins dynein and kinesin. These motors bridge various endosomal subtypes to the microtubule tracks thanks to their cargo-binding domain interacting with endosome-associated proteins...
Includes: Supplementary data
Journal Articles
In collection:
Motors , Polarity
J Cell Sci (2023) 136 (5): jcs260300.
Published: 17 October 2022
..., for intracellular transport. Here we describe how molecular motors and cytoskeletal tracks can generate streaming. Actin Cytoplasmic streaming Dynein Kinesin Microtubules Myosin National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35 GM131752...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (11): jcs259374.
Published: 7 June 2022
...Risa Matsuoka; Masateru Miki; Sonoko Mizuno; Yurina Ito; Chihiro Yamada; Atsushi Suzuki ABSTRACT The Golgi complex plays an active role in organizing asymmetric microtubule arrays, which are essential for polarized vesicle transport. The coiled-coil protein MTCL1 stabilizes microtubules nucleated...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (9): jcs259108.
Published: 6 May 2022
...Julia Bär; Yannes Popp; Tomas Koudelka; Andreas Tholey; Marina Mikhaylova ABSTRACT Detyrosination is a major post-translational modification of microtubules (MTs), which has significant impact on MT function in cell division, differentiation, growth, migration and intracellular trafficking...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (3): jcs258745.
Published: 2 February 2022
...Aaron R. Tipton; Gary J. Gorbsky ABSTRACT The microtubules of the mitotic spindle mediate chromosome alignment to the metaphase plate, then sister chromatid segregation to the spindle poles in anaphase. Previous analyses of spindle microtubule kinetics utilizing fluorescence dissipation after...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259273.
Published: 18 January 2022
... proposed that the APC/C might fulfil other functions, including assembly of the mitotic spindle. Here, we show that the APC/C localizes to centrosomes, the organizers of the eukaryotic microtubule cytoskeleton, specifically during mitosis. Recruitment of the APC/C to spindle poles requires the centrosomal...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (16): jcs256537.
Published: 19 August 2021
...Xiaolei Gao; Saturnino Herrero; Valentin Wernet; Sylvia Erhardt; Oliver Valerius; Gerhard H. Braus; Reinhard Fischer ABSTRACT Centrosomes are important microtubule-organizing centers (MTOC) in animal cells. In addition, non-centrosomal MTOCs (ncMTOCs) have been described in many cell types...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (14): jcs258397.
Published: 20 July 2021
...Nina Schweizer; Jens Lüders ABSTRACT Centrioles are microtubule-based cylindrical structures that assemble the centrosome and template the formation of cilia. The proximal part of centrioles is associated with the pericentriolar material, a protein scaffold from which microtubules are nucleated...
Journal Articles
J Cell Sci (2021) 134 (7): jcs226084.
Published: 13 April 2021
... with mitochondria – the actin-based myosins, as well as the microtubule-based kinesins and dynein. In addition, Miro and TRAK proteins act as adaptors that link kinesin-1 and dynein, as well as myosin of class XIX (MYO19), to mitochondria and coordinate microtubule- and actin-based motor activities. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs248815.
Published: 8 January 2021
..., expressed in muscle cells only, and UNC-45A, expressed in all cells and implicated in regulating both non-muscle myosin II (NMII)- and microtubule (MT)-associated functions. Here, we show that, in vitro and in human and rat cells, UNC-45A binds to the MT lattice, leading to MT bending, breakage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs248047.
Published: 15 September 2020
...Jana Jentzsch; Adal Sabri; Konstantin Speckner; Gertrud Lallinger-Kube; Matthias Weiss; Klaus Ersfeld ABSTRACT The shape of kinetoplastids, such as Trypanosoma brucei , is precisely defined during the stages of the life cycle and governed by a stable subpellicular microtubule cytoskeleton. During...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243543.
Published: 30 July 2020
...Divya Ganapathi Sankaran; Alexander J. Stemm-Wolf; Bailey L. McCurdy; Bharath Hariharan; Chad G. Pearson ABSTRACT Microtubules (MTs) promote important cellular functions including migration, intracellular trafficking, and chromosome segregation. The centrosome, comprised of two centrioles...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241992.
Published: 14 May 2020
...Yung-An Huang; Chih-Hsuan Hsu; Ho-Chieh Chiu; Pei-Yu Hsi; Chris T. Ho; Wei-Lun Lo; Eric Hwang ABSTRACT Microtubules (MTs) are the most abundant cytoskeleton in neurons, and control multiple facets of their development. While the MT-organizing center (MTOC) in mitotic cells is typically located...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241505.
Published: 11 May 2020
... cancers. However, alternative breakpoints in the EML4 gene lead to distinct variants of EML4–ALK with different patient outcomes. Here, we show that, in cell models, EML4–ALK variant 3 (V3), which is linked to accelerated metastatic spread, causes microtubule stabilization, formation of extended...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs239244.
Published: 6 April 2020
... show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly checkpoint (SAC)-dependent arrest in human cells. Live analysis of individual microtubules indicates that 1 g promotes a rapid and reversible reduction in microtubule growth. Unlike most anti-mitotic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs241802.
Published: 13 February 2020
...-translational modifications of tubulin are emerging as mechanisms for regulating microtubule functions, but their impact on neuronal transport is only marginally understood. Here, we have systematically studied the impact of post-translational polyglutamylation on axonal transport. In cultured hippocampal...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (2): jcs237016.
Published: 29 January 2020
...Lou Fourriere; Ana Joaquina Jimenez; Franck Perez; Gaelle Boncompain ABSTRACT Microtubules are part of the dynamic cytoskeleton network and composed of tubulin dimers. They are the main tracks used in cells to organize organelle positioning and trafficking of cargos. In this Review, we compile...
Journal Articles
J Cell Sci (2019) 132 (24): jcs234799.
Published: 13 December 2019
...Xiaolei Gao; Marjorie Schmid; Ying Zhang; Sayumi Fukuda; Norio Takeshita; Reinhard Fischer ABSTRACT Centrosomes are important microtubule-organizing centers (MTOCs) in animal cells. In addition, non-centrosomal MTOCs (ncMTOCs) are found in many cell types. Their composition and structure are only...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 9 October 2019
... rearrangements. The tight association of the actin cytoskeleton with adhesive structures has been extensively studied, whereas the microtubule network in this context has gathered far less attention. In recent years, however, microtubules have emerged as key regulators of cell adhesion and migration through...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2019) 132 (18): jcs232306.
Published: 23 September 2019
...Corinne Pinder; Yuzy Matsuo; Sebastian P. Maurer; Takashi Toda ABSTRACT High-fidelity chromosome segregation relies on proper microtubule regulation. Kinesin-8 has been shown to destabilise microtubules to reduce metaphase spindle length and chromosome movements in multiple species. XMAP215/chTOG...
Includes: Supplementary data