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Keywords: Metastasis
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Journal Articles
J Cell Sci (2023) 136 (20): jcs261483.
Published: 23 October 2023
... fibronectin-binding integrins, α5β1 and αvβ3, to promote stress tolerance, cancer stemness and tumor initiation. Isolation stress Stress tolerance Tumor initiation Metastasis LPAR4 Fibronectin Integrins α5β1 αvβ3 University of California Tobacco-Related Disease Research Program...
Journal Articles
J Cell Sci (2023) 136 (13): jcs260835.
Published: 4 July 2023
... demonstrated an increased fitness for metastasis. * These authors contributed equally to this work ‡ Authors for correspondence ( peter.siegel@mcgill.ca ; santiago.costantino@umontreal.ca ) Handling Editor: Kathleen Green Competing interests The authors declare no competing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (3): jcs260243.
Published: 6 February 2023
... in breast cancer patients. To investigate whether the kinase activity of FER is essential for its oncogenic properties, we developed an ATP analogue-sensitive knock-in allele (FER ASKI ). Specific FER kinase inhibition in MDA-MB-231 cells reduces migration and invasion, as well as metastasis when...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (18): jcs260244.
Published: 14 September 2022
... discovery over 40 years ago. Here, we will describe recent insights into the roles of TNC in tumorigenesis, angiogenesis, immunity and metastasis. In addition to high levels of expression in tumors, and during chronic inflammation, and bacterial and viral infection, TNC is also expressed in lymphoid organs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... amoeboid melanoma migration and dissemination . Curr. Biol. 25 , 2899 - 2914 . 10.1016/j.cub.2015.09.054 Clark , E. A. , Golub , T. R. , Lander , E. S. and Hynes , R. O. ( 2000 ). Genomic analysis of metastasis reveals an essential role for RhoC . Nature 406 , 532...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (21): jcs258418.
Published: 5 November 2021
...-associated transcripts; ETs). Of these, the ET-20 gene localizes in antisense orientation within the tenascin C ( Tnc ) gene locus. TNC is an extracellular matrix protein that is critical for EMT and metastasis formation. Both ET-20 and Tnc are regulated by the EMT master transcription factor Sox4. Notably...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (15): jcs240135.
Published: 10 August 2021
... used an in vivo model. When injected into the tail vein of immunodeficient mice, the MDA-MB-231 cell line preferentially metastasises to the lungs. We used luciferase-expressing MDA-MB-231 cells, transfected with either control or CD99 siRNA molecules, and assayed tumour burden repeatedly over 4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247056.
Published: 22 January 2021
... on diverse cell biological processes involved in metastasis. * Author for correspondence ( Jayanta.Debnath@ucsf.edu ) Competing interests J.D. is a Scientific Advisory Board Member for Vescor Therapeutics, LLC. T.M. is employed by Casma Therapeutics. © 2021. Published by The Company...
Journal Articles
J Cell Sci (2020) 133 (11): jcs237222.
Published: 11 June 2020
... morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with poor patient's prognosis. BMP4...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Cell Migration
J Cell Sci (2019) 132 (20): jcs232645.
Published: 28 October 2019
... activates VLA-4-mediated motility has remained unknown. We now report that VEGFR2 causes PKA-mediated phosphorylation of VLA-4 on S988, an event known to stimulate tumor metastasis while suppressing cytotoxic immune cells. A key partner in this mechanism is the chemokine receptor CXCR4, a well-known...
Includes: Supplementary data
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (4): jcs219907.
Published: 10 December 2018
.... As the macroscopic structure of the lung had been preserved, but cellular material eliminated, we used this DCM to investigate the behaviour of metastasising cancer cells. The breast cancer cell lines MCF7 and MDA231 originate from pleural effusions and thus have past association with the lungs. These lines were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs212563.
Published: 23 August 2018
... by The Company of Biologists Ltd 2018 Summary: Induction of BIM and BMF function in metastatic breast cancer can aid current treatment strategies. Breast cancer Intrinsic apoptosis Metastasis The mammary gland is one of the few organs that completes its development after birth. Mammary...
Journal Articles
J Cell Sci (2017) 130 (20): 3455–3466.
Published: 15 October 2017
... may undergo metastasis. Melanoma Metastasis LPA LPP3 Self-generated gradients Chemotaxis Malignant melanoma is the most aggressive form of skin cancer, accounting for the majority of skin cancer-related deaths ( American Cancer Society, 2014 ). Melanoma is highly treatable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3399–3413.
Published: 1 October 2017
...) inhibited MDA-MB-231 and MCF-7 cell metastasis by repressing epithelial–mesenchymal transition (EMT) in vitro , and suppressed breast cancer metastasis in vivo . Mechanistically, the CCR2 3′UTR modulated the expression of the RhoGAP protein STARD13 via acting as a STARD13 ceRNA in a microRNA-dependent...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2017) 130 (4): 663–669.
Published: 15 February 2017
... dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins...
Includes: Supplementary data