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Keywords: Mechanobiology
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Journal Articles
J Cell Sci (2022) 135 (12): jcs259379.
Published: 21 June 2022
..., the distinctive cytomechanical and morphodynamic profiles of PSCs are accompanied by a number of unique molecular mechanisms. The extent to which such mechanobiological signatures are intertwined with pluripotency regulation remains an open question that may have important implications in developmental...
Journal Articles
J Cell Sci (2022) 135 (10): jcs259586.
Published: 26 May 2022
... and Technology Innovation Commission http://dx.doi.org/10.13039/501100010877 JCYJ20200109142001798 SGDX2020110309520303 National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 11972316 Fluid shear stress Mechanobiology Circulating tumor cell Histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs258969.
Published: 30 March 2022
... Highlighted Article: We provide insights into nanoscale mechanotransduction processes at the nuclear envelope and the role of emerin oligomerization at the LINC complex for maintaining nuclear integrity during mechanical challenges to cells. Laminopathy Super-resolution microscopy Mechanobiology...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (4): jcs258929.
Published: 22 February 2022
... thawed from a low-passage frozen batch and tested for mycoplasma within 6 months. MDCK cells expressing GFP-tagged E-cadherin (MDCK-E-cad–GFP) were kindly provided by Dr Benoit Ladoux's lab (Mechanobiology Institute, National University of Singapore) and were tested for mycoplasma. Cells were cultured...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (24): jcs259012.
Published: 22 December 2021
... the transcellular pathway is of minor importance. Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 SFB1348 Max-Planck-Gesellschaft http://dx.doi.org/10.13039/501100004189 Cadherin Mechanobiology Cell adhesion Endothelial cell junctions Vascular biology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (20): jcs258749.
Published: 28 October 2021
... a novel view of talin as a molecular information processing and memory device that plays a key role in determining cellular responses to changes in extracellular matrix composition, organization and physical properties. Integrin Mechanobiology Mechanomemory Mechanotransduction Memory MeshCODE...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (16): jcs258544.
Published: 18 August 2021
... function. Centrosome Cilia Cytoskeleton Mechanobiology Organelle assembly Rootlets Medical Research Council http://dx.doi.org/10.13039/501100007155 University of Cambridge http://dx.doi.org/10.13039/501100000735 Isaac Newton Trust http://dx.doi.org/10.13039...
Journal Articles
J Cell Sci (2021) 134 (16): jcs255455.
Published: 17 August 2021
.... Highlighted Article: We report a genetically encoded fluorescent reporter sensitive to all known activators of GPR68, a G-protein-coupled receptor involved in many important physiological functions. Mechanobiology GPCR Fluid shear stress Genetically encoded fluorescent reporter Western...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (12): jcs257709.
Published: 21 June 2021
... fibroblasts. ECM stiffness Mechanobiology Proliferation Lamellipodin FAK Rac The extracellular matrix (ECM) provides structural and mechanical support for cells in living tissue. Cells exhibit pathological behaviors in response to increased ECM stiffness, including accelerated cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247783.
Published: 22 December 2020
... of the processes by which epithelial tumours regulate their tumour microenvironment, and how new insights into tumour–microenvironment interactions have led to ideas on targeting it as treatments. Microenvironment Cancer Extracellular matrix Mechanobiology Signalling Fibroblasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs244731.
Published: 30 October 2020
..., we discuss the mechanisms of megakaryocyte differentiation and how bona fide platelets are brought into circulation. Megakaryocyte Platelet Cytoskeleton Mechanobiology Blood platelets are crucial during hemostasis to prevent hemorrhages. At sites of vascular injury, circulating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240861.
Published: 4 June 2020
... new functions. Clathrin Endocytosis Mechanics Mechanobiology Actin Cell signaling Endocytosis is the process by which eukaryotic cells internalize substances from their surroundings. Although different endocytosis pathways have been described, they all rely on the formation...
Journal Articles
J Cell Sci (2020) 133 (5): jcs236166.
Published: 2 March 2020
... Mechanobiology Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is a pattern recognition receptor expressed primarily on cells of myeloid origin, including macrophages, dendritic cells and neutrophils ( Brown, 2006 ). The ligand for Dectin-1 is a highly immunogenic glucose...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (9): jcs229013.
Published: 30 April 2019
...Carlos Matellan; Armando E. del Río Hernández ABSTRACT The field of mechanobiology studies how mechanical properties of the extracellular matrix (ECM), such as stiffness, and other mechanical stimuli regulate cell behaviour. Recent advancements in the field and the development of novel biomaterials...
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 3 April 2019
... Focal adhesion Mechanobiology Phosphoproteomics Protein engineering Talin Highlighted Article: Transmission of mechanical forces through talin regulates adhesion complex composition and phosphotyrosine signaling. Talin rod subdomains and their mechanical activation are required for cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (24): jcs218156.
Published: 20 December 2018
... declare no competing or financial interests. Summary: The transmission of mechanical signals through cellular assemblies regulates collective cell behavior. Cell–cell junctions Mechanobiology Actin cytoskeleton Collective cell migration Active matter The ability of metazoan cells...
Journal Articles
J Cell Sci (2018) 131 (21): jcs218479.
Published: 29 October 2018
... by The Company of Biologists Ltd 2018 Summary: Organelles are subjected to mechanical forces within the crowded cytoplasm of eukaryotic cells. We discuss the effect of forces on two organelles, the nucleus and the mitochondrion. Mechanobiology Membrane Mitochondria Nucleus Organelle ER...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (12): jcs211334.
Published: 27 June 2018
.../ Highlighted Article: Myosin-1c is a regulator of intercellular tension that can promote tension generation from the extracellular domain of E-cadherin, propagating actomyosin-generated force to intercellular junctions. α-actinin Synaptopodin Myosin Junction Mechanobiology Cell–cell adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs216010.
Published: 21 June 2018
... to characterize mechanical aspects of cell monolayers. Mechanobiology Cell mechanics Cell rheology Cell structure Substrate stiffness * Author for correspondence ( krisdahl@cmu.edu ) Competing interests The authors declare no competing or financial interests. 25 1 2018 4 5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs210393.
Published: 8 March 2018
... circuits . Neuron   66 , 681 - 694 . 10.1016/j.neuron.2010.05.008 Tyler , W. J. ( 2011 ). Noninvasive neuromodulation with ultrasound? A continuum mechanics hypothesis . Neuroscientist   17 , 25 - 36 . Tyler , W. J. ( 2012 ). The mechanobiology of brain function . Nat. Rev...
Includes: Supplementary data