...Vinay Kumar Dubey; Souradeep R. Sarkar; Vairavan Lakshmanan; Rimple Dalmeida; Akash Gulyani; Dasaradhi Palakodeti ABSTRACT Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital...

... in presynaptic differentiation remain largely unclear. Here, we report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (MT1-MMP; also known as MMP14) facilitates agrin deposition and signaling during presynaptic development at NMJs. Firstly, agrin deposition along axons...

.... Importantly, we show that osteoclastic bone resorption becomes sensitive to inhibition of matrix metalloproteinases in the presence, but not in the absence, of osteoblast lineage cells. We propose that this may be due to the direct action of osteoblast-lineage-derived MMP-13 on bone resorption...

... extend the repertoire of filamin activities to include control of extracellular matrix (ECM) degradation. We show that knockdown of filamin increases matrix metalloproteinase (MMP) activity and induces MMP2 activation, enhancing the ability of cells to remodel the ECM and increasing their invasive...

...Abdi Ghaffari; Yunyaun Li; Ruhangiz T. Kilani; Aziz Ghahary Matrix metalloproteinases (MMPs) are implicated in the degradation of the extracellular matrix during development and tissue repair, as well as in pathological conditions such as tumor invasion and fibrosis. MMP expression by stromal cells...

... of a gelatin matrix. Consistent with these findings are the observations that VAMP3 and SNAP23 were required for secretion of the matrix metalloproteinases MMP2 and MMP9, whereas both these SNAREs as well as syntaxin-13 were necessary for efficient delivery of MT1-MMP to the cell surface. Secretion of MMPs...

.... Herein, we demonstrate that the loss of the VSMC differentiated phenotype, as the repression of contractile-protein expression, is correlated with a dramatic upregulation of the membrane-anchored matrix metalloproteinase MT1-MMP (also known as MMP14 and membrane-type 1 matrix metalloproteinase). Matrix...

... pathogenesis. Am. J. Med. Sci. 297 , 91 -104. Yu, Q. and Stamenkovic, I. ( 2000 ). Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 14 , 163 -176. We would like to thank E. A. Hawthorne for technical...

...Sara A. Illman; Kaisa Lehti; Jorma Keski-Oja; Jouko Lohi Epilysin (MMP-28) is the newest member of the matrix metalloproteinase (MMP) family. Although it is expressed in a number of tissues, no biological substrates or functions for this enzyme have been identified yet. We have expressed...

... of Biologists Limited 2005 2005 Angiogenesis Elastin Matrix metalloproteinase Elastin receptor siRNA Angiogenesis involves the formation of capillaries from preexisting microvessels and therefore contributes to vascular remodeling and maturation ( Carmeliet, 2000 ). It plays a pivotal function...

...Lydia E. Wroblewski; P.-J. M. Noble; Adelina Pagliocca; D. Mark Pritchard; C. Anthony Hart; Fiona Campbell; Andrew R. Dodson; Graham J. Dockray; Andrea Varro Epithelial cell responses to bacterial infection include induction of matrix metalloproteinase 7 (MMP-7). Here, we identify increased MMP-7...