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Keywords: Macropinocytosis
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Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2023) 136 (15): jcs260912.
Published: 11 August 2023
... by fluid-phase macropinocytosis. Pulse-chase studies revealed that intracellular HSA molecules co-localised with FcRn in acidic endosomal structures and that the wildtype HSA, but not the non-FcRn-binding HSA H464Q mutant, was excluded from late endosomes and/or lysosomes. Live imaging revealed that HSA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (18): jcs260107.
Published: 21 September 2022
... of undigested or partially digested nutrients using a signal transduction pathway. Polyphosphate Macropinocytosis Exocytosis Membrane recycling Membrane fluidity Dictyostelium National Institutes of Health http://dx.doi.org/10.13039/100000002 GM118355 GM139486 Texas A and M...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (4): jcs259284.
Published: 21 February 2022
...Zachary I. Mendel; Mack B. Reynolds; Basel H. Abuaita; Mary X. O'Riordan; Joel A. Swanson ABSTRACT The internalization of solutes by macropinocytosis provides an essential route for nutrient uptake in many cells. Macrophages increase macropinocytosis in response to growth factors and other stimuli...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (14): jcs258495.
Published: 20 July 2021
...Kia Wee Tan; Viola Nähse; Coen Campsteijn; Andreas Brech; Kay Oliver Schink; Harald Stenmark ABSTRACT Macropinocytosis allows cells to take up extracellular material in a non-selective manner into large vesicles called macropinosomes. After internalization, macropinosomes acquire...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
... and scission. Dominant-negative Rab5, which obliterates macropinocytosis, had no effect on the development of membrane ruffles. However, Rab5-containing vesicles were recruited to circular membrane ruffles, and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent endomembrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs231639.
Published: 16 August 2019
...Gilbert Salloum; Charles T. Jakubik; Zahra Erami; Samantha D. Heitz; Anne R. Bresnick; Jonathan M. Backer ABSTRACT Macropinocytosis is an actin-dependent but clathrin-independent endocytic process by which cells nonselectively take up large aliquots of extracellular material. Macropinocytosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224998.
Published: 24 January 2019
...Thomas D. Williams; Sew-Yeu Peak-Chew; Peggy Paschke; Robert R. Kay ABSTRACT Macropinocytosis is an actin-driven process of large-scale and non-specific fluid uptake used for feeding by some cancer cells and the macropinocytosis model organism Dictyostelium discoideum . In Dictyostelium...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs220517.
Published: 16 November 2018
... phosphorylation after PDGF treatment suggests that later stages of macropinocytosis carry Akt signals into the cell. Future experiments should address how pAkt reaches TSC1/2 on lysosomes to influence mTORC1 signaling. This and previous studies of signaling to Akt ( Yoshida et al., 2015b ; Pacitto et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs213736.
Published: 21 March 2018
...Thomas D. Williams; Robert R. Kay ABSTRACT Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we developed a high-throughput flow cytometry assay to measure macropinocytosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 3158–3172.
Published: 15 September 2017
...Hironori Inaba; Koji Yoda; Hiroyuki Adachi ABSTRACT Macropinocytosis involves the uptake of large volumes of fluid, which is regulated by various small GTPases. The Dictyostelium discoideum protein GflB is a guanine nucleotide exchange factor (GEF) of Rap1, and is involved in chemotaxis. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4091–4104.
Published: 1 November 2016
... route for VEGFR2 only in the absence of ligand. Intriguingly, VEGFA induces a new internalisation itinerary for VEGFR2, the pathway of macropinocytosis, which becomes the prevalent endocytic route for the receptor in the presence of ligand, whereas the contribution of the clathrin-mediated route becomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (14): 2697–2705.
Published: 15 July 2016
...Gareth Bloomfield; Robert R. Kay ABSTRACT Macropinocytosis is a means by which eukaryotic cells ingest extracellular liquid and dissolved molecules. It is widely conserved amongst cells that can take on amoeboid form and, therefore, appears to be an ancient feature that can be traced back...
Journal Articles
J Cell Sci (2015) 128 (23): 4407–4419.
Published: 1 December 2015
...Jet Phey Lim; Prajakta Gosavi; Justine D. Mintern; Ellen M. Ross; Paul A. Gleeson ABSTRACT The regulation of macropinocytosis, a specialised endocytosis pathway, is important for immune cell function. However, it is not known whether the biogenesis of macropinosomes involves one or more distinct...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (9): 1773–1786.
Published: 1 May 2015
... neural crest cells through cell surface internalization events that include clathrin‐mediated endocytosis and macropinocytosis. Both of these processes are dependent upon the function of dynamin, and inhibition of Cad6B internalization abrogates neural crest cell EMT and migration. Collectively, our...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4296–4307.
Published: 15 September 2013
...Oliver Hoeller; Parvin Bolourani; Jonathan Clark; Len R. Stephens; Phillip T. Hawkins; Orion D. Weiner; Gerald Weeks; Robert R. Kay Summary Class-1 PI3-kinases are major regulators of the actin cytoskeleton, whose precise contributions to chemotaxis, phagocytosis and macropinocytosis remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4106–4114.
Published: 1 December 2011
... macropinosomes ( Fig. 1E ; images not shown). Fig. 1. Focal activation of Rac1 during macropinocytosis. ( A–D ) FRET interactions of Cerulean-PBD and Citrine–Rac1 in control (A,C) and latrunculin B-treated BMM (B,D) in response to M-CSF. (A,B) Left: Phase contrast; right: G *. Scale bars: 4 μm. (C,D...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2013–2020.
Published: 15 June 2011
...-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis. The data thus far suggest recruitment of cadherin towards these sites on the basis of interactions with molecules already known to be associated with lamellipodia and membrane ruffles. Cadherins, however, are cell–cell...
Includes: Multimedia, Supplementary data