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Keywords: Macrophage
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (19): jcs260511.
Published: 3 October 2022
...Vasco Rodrigues; Sarah Taheraly; Mathieu Maurin; Mabel San-Roman; Emma Granier; Anaël Hanouna; Philippe Benaroch ABSTRACT A feature of HIV-1 replication in macrophages is that viral assembly occurs at the limiting membrane of a compartment often named the virus-containing compartment (VCC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (13): jcs259544.
Published: 8 July 2022
...Kuihao Chen; Qiaoyan Man; Jiaen Miao; Wenjing Xu; Yangchen Zheng; Xiuli Zhou; Zhe Gao ABSTRACT Macrophage polarization plays a key role in the inflammatory response. Various ion channels expressed in macrophages have been documented, but very little is known about their roles in macrophage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (1): jcs260529.
Published: 3 January 2022
...Aarthi Subramani; Maria E. L. Hite; Sarah Garcia; Jack Maxwell; Hursha Kondee; Grace E. Millican; Erin E. McClelland; Rebecca L. Seipelt-Thiemann; David E. Nelson ABSTRACT Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs258429.
Published: 15 September 2021
...Marielle Saclier; Sabrina Ben Larbi; Ha My Ly; Eugénie Moulin; Rémi Mounier; Bénédicte Chazaud; Gaëtan Juban ABSTRACT Duchenne muscular dystrophy is a genetic muscle disease characterized by chronic inflammation and fibrosis mediated by a pro-fibrotic macrophage population expressing pro...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (5): jcs252320.
Published: 11 February 2021
... of borreliae by immune cells, like macrophages, is decisive for the outcome of a respective infection. Here, we use, for the first time, focused ion beam scanning electron microscopy tomography (FIB-SEM tomography) to visualize the interaction of borreliae with primary human macrophages with high resolution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs248864.
Published: 23 December 2020
... RAW264.7 macrophages and primary murine macrophages undergoing interleukin (IL-4)-induced MGC formation. CD301 + MGCs were identified in biopsy specimens of human inflammatory lesions. Function-inhibiting CD301 antibodies or CRISPR/Cas9 deletion of the two mouse CD301 genes (Mgl1 and Mgl2) inhibited IL-4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248344.
Published: 3 December 2020
... kinase BTK Macrophage Receptor signaling Inflammation is vital for resolving infections or sterile insults, but, when chronic or deregulated, it becomes a health problem of global importance. Among the major driving forces of inflammation are pro-inflammatory cytokines, released...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (5): jcs252973.
Published: 25 November 2020
... of xenophagy in macrophages targets Mtb to autophagosomes; however, how Mtb is targeted to autophagosomes in human macrophages at a high spatial and temporal resolution is unknown. Here, we use human induced pluripotent stem cell-derived macrophages (iPSDMs) to study the human macrophage response to Mtb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs244400.
Published: 23 July 2020
...Madhavi Vijayan; Cheuk-Lun Lee; Vera H. H. Wong; Xia Wang; Kungfeng Bai; Jian Wu; Hannu Koistinen; Markku Seppälä; Kai-Fai Lee; William S. B. Yeung; Ernest H. Y. Ng; Philip C. N. Chiu ABSTRACT Decidual macrophages constitute 20–30% of the total leukocytes in the uterus of pregnant women, regulating...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (13): jcs239871.
Published: 8 July 2020
... responses in the non-ciliated macrophage. We propose that ciliary proteins, including IFT88, KIF3A, TTBK2 and NPHP4, act outside of the ciliary axoneme to tune cytoplasmic NFκB signalling and specify the downstream cell response. This is thus a non-canonical function for ciliary proteins in shaping cellular...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (5): jcs242776.
Published: 22 June 2020
...Thibault Rosazza; Hervé Lecoeur; Thierry Blisnick; Maryse Moya-Nilges; Pascale Pescher; Phillipe Bastin; Eric Prina; Gerald F. Späth ABSTRACT Leishmania spp. are obligate intracellular parasites that infect phagocytes, notably macrophages. No information is available on how Leishmania parasites...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs239939.
Published: 8 April 2020
... effluxes host ATP generated from increased glycolysis, which is converted into extracellular adenosine to create an anti-inflammatory milieu within infected cells via receptor-mediated signalling. ATP Ectonucleotidase Adenosine receptor Leishmania donovani Macrophage Leishmania...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs237883.
Published: 5 March 2020
... of phagocytosis, and changes in macrophage morphology during phagocytosis related to both engulfment and target degradation. Our results provide a high-resolution method for quantifying phagocytosis that provides opportunities to better understand the cellular and molecular regulation of this fundamental...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (23): jcs237271.
Published: 2 December 2019
...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs224618.
Published: 18 February 2019
... rearrangements drive macrophage recruitment to wounds in Drosophila . We find that the actin-regulatory protein Ena is a master regulator of lamellipodial dynamics in migrating macrophages, where it remodels the cytoskeleton to form linear filaments that can then be bundled together by the cross-linker Fascin...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (5): jcs213272.
Published: 6 March 2018
... to form PtdIns(5)P in vitro . However, the in vivo conversion of the polyphosphoinositide into PtdIns(5)P by the phosphatase has not yet been demonstrated, and the role of TMEM55a remains poorly understood. Here, we found that mouse macrophages (Raw264.7) deficient in TMEM55a showed an increased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210492.
Published: 2 February 2018
..., interferes with tip and stalk cell specification, and hinders the function of filopodial protrusions required for precise guidance of vascular sprouts. In addition, ABA skews macrophage polarization towards the M1 phenotype characterized by anti-angiogenic marker expression. In accordance with this, ABA...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (22): 3801–3808.
Published: 15 November 2017
...Francisco Barros-Becker; Pui-Ying Lam; Robert Fisher; Anna Huttenlocher ABSTRACT Cell motility is required for diverse processes during immunity and inflammation. Classically, leukocyte motility is defined as an amoeboid type of migration, however some leukocytes, like macrophages, also employ...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (17): 2797–2807.
Published: 1 September 2017
...Doris Lou Demy; Muriel Tauzin; Mylène Lancino; Véronique Le Cabec; Michael Redd; Emi Murayama; Isabelle Maridonneau-Parini; Nikolaus Trede; Philippe Herbomel ABSTRACT Macrophages infiltrate and establish in developing organs from an early stage, often before these have become vascularized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1730–1739.
Published: 15 May 2017
...Matthew R. Miller; Eric W. Miller; Scott D. Blystone ABSTRACT Having previously located the formin FMNL1 in macrophage podosomes, we developed an in vivo model to assess the role of FMNL1 in the migration activities of primary macrophages. Deletion of FMNL1 in mice was genetically lethal; however...
Includes: Supplementary data