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Keywords: Lysosome
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2022) 135 (6): jcs259455.
Published: 21 March 2022
....2010.06.010 Davidson , S. M. and Vander Heiden , M. G. ( 2017 ). Critical functions of the lysosome in cancer biology . Annu. Rev. Pharmacol. Toxicol. 57 , 481 - 507 . 10.1146/annurev-pharmtox-010715-103101 Di Paola , S. , Scotto-Rosato , A. and Medina , D. L...
Includes: Supplementary data
Journal Articles
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Membrane Trafficking
J Cell Sci (2022) 135 (1): jcs259183.
Published: 10 January 2022
... on Salmonella vacuoles whereas that with SKIP is incidental. In the non-infectious context, however, the interaction with SKIP is essential for the recruitment and activity of kinesin-3 only on a fraction of the lysosomes. Finally, our results show that, in infected cells, the presence of SifA establishes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 3 August 2021
... intracellular pathogens is of utmost significance. Pathogenic intrusion activates autophagy and phagocytic pathways that culminate in the lysosome, a vital organelle responsible for pathogen clearance. The transcription factor TFEB plays a pivotal role in autophagy-lysosomal function. Although TFEB...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (11): jcs246694.
Published: 8 June 2021
...Cristina Escrevente; Liliana Bento-Lopes; José S. Ramalho; Duarte C. Barral ABSTRACT Lysosomes are dynamic organelles, capable of undergoing exocytosis. This process is crucial for several cellular functions, namely plasma membrane repair. Nevertheless, the molecular machinery involved...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (10): jcs255463.
Published: 27 May 2021
...Luther J. Davis; Nicholas A. Bright; James R. Edgar; Michael D. J. Parkinson; Lena Wartosch; Judith Mantell; Andrew A. Peden; J. Paul Luzio ABSTRACT To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
... communication by G protein-coupled receptors . FEBS Lett. 589 , 1607 - 1619 . 10.1016/j.febslet.2015.05.007 Huber , L. A. and Teis , D. ( 2016 ). Lysosomal signaling in control of degradation pathways . Curr. Opin. Cell Biol. 39 , 8 - 14 . 10.1016/j.ceb.2016.01.006...
Journal Articles
J Cell Sci (2021) 134 (4): jcs256255.
Published: 22 February 2021
... of mitophagy reporter zebrafish shows mitophagy occurs via a piece-by-piece mechanism in vivo . Hypoxia induces mitophagy in muscle in a bnip3 -dependent but pink1 -independent manner. Autophagy Hypoxia Fasting Mitochondria Lysosome Mitophagy is the removal of damaged mitochondria via...
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Journal Articles
J Cell Sci (2021) 134 (2): jcs248658.
Published: 27 January 2021
...Anthony J. Morgan; Antony Galione ABSTRACT Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca 2+ entry (SOCE) by these agents...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs247080.
Published: 9 July 2020
... endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment of Rab7 to endosomes requires the Mon1–Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1–Ccz1 complex requires a third...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs236661.
Published: 11 June 2020
..., disruption of several Rab proteins can manifest in metabolic diseases or cancer. Rab32 is expressed in many secretory epithelial cells but its role in cellular metabolism is virtually unknown. In this study, we find that Rab32 associates with lysosomes and regulates proliferation and cell size of Hep3B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs228114.
Published: 22 May 2020
...Åsa B. Birgisdottir; Terje Johansen ABSTRACT Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded...
Journal Articles
J Cell Sci (2019) 132 (21): jcs222570.
Published: 13 November 2019
... into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis. References Anthony , J. C. , Yoshizawa , F. , Anthony , T. G. , Vary , T. C. , Jefferson , L. S. and Kimball , S. R. ( 2000 ). Leucine...
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Journal Articles
J Cell Sci (2019) 132 (19): jcs231753.
Published: 9 October 2019
... not yet been defined. In this study, experiments using quantitative colocalization analysis reveal that COMMD1 modulates copper-responsive ATP7B trafficking through recruitment to PtdIns(4,5)P 2 . Decreased COMMD1 abundance results in loss of ATP7B from lysosomes and the trans -Golgi network (TGN) in high...
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Journal Articles
In collection:
Autophagy
J Cell Sci (2019) 132 (19): jcs234195.
Published: 1 October 2019
... is independent of the complex's activity as a RAB-3 GAP and a RAB-18 GEF. Loss of rbg-1 activity promotes lysosomal biogenesis and function, and also suppresses the accumulation of non-functional autolysosomes in epg-5 mutants. The mobility of late endosome- and lysosome-associated RAB-7 is reduced in epg-5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs189134.
Published: 15 May 2019
...Jan van der Beek; Caspar Jonker; Reini van der Welle; Nalan Liv; Judith Klumperman ABSTRACT Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of the endo-lysosomal system...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs226183.
Published: 25 March 2019
... independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca 2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair. This article has an associated...
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Journal Articles
J Cell Sci (2019) 132 (5): jcs229500.
Published: 28 February 2019
... the early endosomes in melanocytes, called stage I melanosomes. PIKfyve activity controls the membrane remodeling of stage I melanosomes, which regulates PMEL abundance, sorting and processing. PIKfyve activity also affects stage I melanosome kiss-and-run interactions with lysosomes, which are required...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs223883.
Published: 1 February 2019
...Peace Atakpa; Laura M. van Marrewijk; Michael Apta-Smith; Sumita Chakraborty; Colin W. Taylor ABSTRACT The dipeptide glycyl- l -phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (19): jcs214304.
Published: 4 October 2018
... Summary: This review highlights the recent advances of how the ubiquitin-proteasome system and autophagy can be coordinated by p62-dependent phase separation reactions. Quality control Proteostasis Selective autophagy Cargo receptor Degradation Lysosome SQSTM1 Aggrephagy...
Journal Articles
J Cell Sci (2018) 131 (15): jcs215210.
Published: 3 August 2018
... biogenesis and autophagy, are linked by the endolysosomal pathway. Exosomes are cargo-laden extracellular vesicles that arise from endosome-derived multivesicular bodies, and autophagy is a lysosomal-dependent degradation and recycling pathway. Recent studies have revealed shared molecular machinery between...