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Keywords: Lysosome
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Journal Articles
In collection:
Metabolism
J Cell Sci (2023) 136 (22): jcs261402.
Published: 29 November 2023
... lysosomes without affecting insulin-induced dissociation of the TSC complex from lysosomes, thereby enabling complete activation of mTORC1. We also show that under prolonged starvation conditions, cholesterol coordinates with autophagy to support mTORC1 reactivation on lysosomes thereby restoring insulin...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (14): jcs261003.
Published: 21 July 2023
... kinase 2 (LRRK2), a Parkinson's disease-associated kinase. Recent studies suggest that Rab29 regulates LRRK2, whereas the mechanism by which Rab29 is regulated remained unclear. Here, we report a novel phosphorylation in Rab29 that is not mediated by LRRK2 and occurs under lysosomal overload stress. Mass...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2023) 136 (9): jcs260806.
Published: 12 May 2023
...–lysosome fusion reaction that is driven by micromolar concentrations of Ca 2+ in the absence of ATP and cytosol. Investigating classical fusion and Ca 2+ -driven fusion (CaFu) side-by-side in vitro , using the same membrane preparations, we show that CaFu is faster than standard fusion (StaFu), leads...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (1): jcs259183.
Published: 10 January 2022
... on Salmonella vacuoles whereas that with SKIP is incidental. In the non-infectious context, however, the interaction with SKIP is essential for the recruitment and activity of kinesin-3 only on a fraction of the lysosomes. Finally, our results show that, in infected cells, the presence of SifA establishes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 3 August 2021
... intracellular pathogens is of utmost significance. Pathogenic intrusion activates autophagy and phagocytic pathways that culminate in the lysosome, a vital organelle responsible for pathogen clearance. The transcription factor TFEB plays a pivotal role in autophagy-lysosomal function. Although TFEB...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (11): jcs246694.
Published: 8 June 2021
...Cristina Escrevente; Liliana Bento-Lopes; José S. Ramalho; Duarte C. Barral ABSTRACT Lysosomes are dynamic organelles, capable of undergoing exocytosis. This process is crucial for several cellular functions, namely plasma membrane repair. Nevertheless, the molecular machinery involved...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (10): jcs255463.
Published: 27 May 2021
...Luther J. Davis; Nicholas A. Bright; James R. Edgar; Michael D. J. Parkinson; Lena Wartosch; Judith Mantell; Andrew A. Peden; J. Paul Luzio ABSTRACT To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
... Lysosome Nuclear calcium Ca 2+ ions influence numerous signaling pathways within the vast majority of cells and thus impact nearly every aspect of life ( Berridge et al., 2000 ). In order to adapt to changing intra- and extra-cellular conditions, cells must induce specific signaling cascades...
Journal Articles
J Cell Sci (2021) 134 (4): jcs256255.
Published: 22 February 2021
... Mitochondria Lysosome Mitophagy is the removal of damaged mitochondria via autophagy, the lysosomal pathway responsible for degrading and recycling cellular components. It prevents cellular damage and apoptosis ( Youle, 2019 ), and defective mitophagy has been linked to both acute and chronic disease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs248658.
Published: 27 January 2021
...Anthony J. Morgan; Antony Galione ABSTRACT Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca 2+ entry (SOCE) by these agents...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs247080.
Published: 9 July 2020
... endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment of Rab7 to endosomes requires the Mon1–Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1–Ccz1 complex requires a third...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs236661.
Published: 11 June 2020
..., disruption of several Rab proteins can manifest in metabolic diseases or cancer. Rab32 is expressed in many secretory epithelial cells but its role in cellular metabolism is virtually unknown. In this study, we find that Rab32 associates with lysosomes and regulates proliferation and cell size of Hep3B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs228114.
Published: 22 May 2020
...Åsa B. Birgisdottir; Terje Johansen ABSTRACT Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded...
Journal Articles
J Cell Sci (2019) 132 (21): jcs222570.
Published: 13 November 2019
... into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis. * Author for correspondence ( sabatini@wi.mit.edu ) Competing interests The authors declare no competing or financial interests. © 2019. Published...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs231753.
Published: 9 October 2019
... not yet been defined. In this study, experiments using quantitative colocalization analysis reveal that COMMD1 modulates copper-responsive ATP7B trafficking through recruitment to PtdIns(4,5)P 2 . Decreased COMMD1 abundance results in loss of ATP7B from lysosomes and the trans -Golgi network (TGN) in high...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2019) 132 (19): jcs234195.
Published: 1 October 2019
... is independent of the complex's activity as a RAB-3 GAP and a RAB-18 GEF. Loss of rbg-1 activity promotes lysosomal biogenesis and function, and also suppresses the accumulation of non-functional autolysosomes in epg-5 mutants. The mobility of late endosome- and lysosome-associated RAB-7 is reduced in epg-5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs189134.
Published: 15 May 2019
...Jan van der Beek; Caspar Jonker; Reini van der Welle; Nalan Liv; Judith Klumperman ABSTRACT Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of the endo-lysosomal system...
Includes: Supplementary data
Journal Articles