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Keywords: Liquid–liquid phase separation
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Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2022) 135 (3): jcs259430.
Published: 3 February 2022
... and attenuated the first wave of insulin release. Although previous analyses in vitro and in neurons have suggested that secretory machinery might assemble through liquidliquid phase separation, analysis of endogenously labeled ELKS in pancreatic islets indicated that its dynamics is inconsistent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs259097.
Published: 12 January 2022
... was hyperphosphorylated at Ser89, leading to enhanced cytoplasmic sequestration. Finally, live-cell imaging indicated that TAZ exhibits properties of liquidliquid phase separation (LLPS). These observations indicate that TAZ, as an effector of Hippo signaling, suppresses the myogenic differentiation machinery...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258578.
Published: 3 September 2021
... it is clear that the FUS segment is required for oncogenic transformation, the mechanism of FUS-CHOP-induced transcriptional activation is unknown. Recently, some transcription factors and super enhancers have been proposed to undergo liquidliquid phase separation and form membraneless compartments...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
Series: SUBJECT COLLECTION: CILIA AND FLAGELLA
J Cell Sci (2021) 134 (15): jcs258626.
Published: 3 August 2021
... for the dynein assembly process, and, in mammals, defects lead to primary ciliary dyskinesia, which results in infertility, bronchial problems and failure to set up the left-right body axis correctly. Liquidliquid phase separation (LLPS) has been proposed to underlie the formation of numerous membrane-less...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs258897.
Published: 26 July 2021
... PCM proteins and nucleate microtubules in cells. We propose that CCs and LCRs, two prevalent sequence features in the centrosomal proteome, are preserved under evolutionary pressure in part to mediate liquid-liquid phase separation, a process that bestows upon the centrosome distinct properties...
Includes: Supplementary data