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Keywords: Lamellipodia
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Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... lamellipodia defects in CK1α-depleted macrophages. Therefore, we conclude that basal phosphorylation of WAVE by CK1α protects it from premature ubiquitin-dependent degradation, thus promoting WAVE function in vivo . This article has an associated First Person interview with the first author of the paper. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs254011.
Published: 19 July 2021
.... and Watanabe , N. ( 2013 ). Can filament treadmilling alone account for the F-actin turnover in lamellipodia? Cytoskeleton (Hoboken) 70 , 179 - 190 . 10.1002/cm.21098 Moriyama , K. and Yahara , I. ( 2002 ). Human CAP1 is a key factor in the recycling of cofilin and actin...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
... , A. et al. ( 2006 ). Galectin-8 binds specific β1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells . Exp. Cell Res. 312 , 374 - 386 . 10.1016/j.yexcr.2005.10.025 Case , L. B. and Waterman , C. M. ( 2011 ). Adhesive F-actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs248732.
Published: 13 January 2021
...Indranil Ghosh; Raman K. Singh; Manjari Mishra; Shobhna Kapoor; Siddhartha S. Jana ABSTRACT Cells can adopt both mesenchymal and amoeboid modes of migration through membrane protrusive activities, namely formation of lamellipodia and blebbing. How the molecular players control the transition...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs245985.
Published: 3 August 2020
... this lamellipodia appeared, giving an apparent increase in bound receptors of up to 50%. Our findings show how parameters other than the specific protein–protein interaction can influence binding behavior at cell–cell contacts. © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2530–2540.
Published: 1 August 2017
...Yuka Ikeda; Katsuhisa Kawai; Akira Ikawa; Kyoko Kawamoto; Youhei Egami; Nobukazu Araki ABSTRACT Lamellipodia are sheet-like cell protrusions driven by actin polymerization mainly through Rac1, a GTPase molecular switch. In Fcγ receptor-mediated phagocytosis of IgG-opsonized erythrocytes (IgG-Es...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2329–2342.
Published: 15 June 2016
.... To study haptotaxis in response to gradients, we utilized microfluidic chambers to generate gradients of the ECM protein fibronectin, and imaged the cell migration response. Lamellipodia are fan-shaped protrusions that are common in migrating cells. Here, we define a new function for lamellipodia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3796–3810.
Published: 15 October 2015
...Tadamoto Isogai; Rob van der Kammen; Daniela Leyton-Puig; Katarzyna M. Kedziora; Kees Jalink; Metello Innocenti ABSTRACT Protrusion of lamellipodia and ruffles requires polymerization of branched actin filaments by the Arp2/3 complex. Although regulation of Arp2/3 complex activity has been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1455–1464.
Published: 15 April 2015
... ). Fig. 4. Pcdh17 regulates cell motility by recruiting the WAVE complex to peripheral cell–cell contacts. (A) The behavior of U251 cells (lacking endogenous Pcdh17) after their collision. When two wild‐type cells collide, lamellipodia (orange) and associated proteins are lost from their contact sites...
Journal Articles
J Cell Sci (2014) 127 (17): 3862–3876.
Published: 1 September 2014
... imaged for 5 h at 6-min intervals with an Axiovert microscope (Zeiss) equipped with an Orca II CCD camera (Hamamatsu), and analyzed with ImageJ (NIH). For lamellipodial dynamics, frames were analyzed with ImageJ by counting the number of lamellipodia forming during 1 or 5 h. Persistence of protrusions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4572–4588.
Published: 15 October 2013
... accompanied by protrusion of membrane ruffles and lamellipodia. In two-dimensional migration, protrusion of these thin sheets of cytoplasm is considered relevant to both exploration of new space and initiation of nascent adhesion to the substratum. Lamellipodium formation can be potently stimulated by Rho...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4262–4273.
Published: 15 September 2013
... or indirectly to these cytoskeletal-modifying structural proteins to promote changes in neurite morphology through molecular mechanisms that are currently unknown. Alternatively, a potentially weak adhesion site with ECM at the leading edge of lamellipodia of CRMP3 −/− neurons might cause a retrograde flow...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2411–2423.
Published: 1 June 2013
... and actin dynamics. In many cell types, CIP4 functions in vesicle formation, endocytosis and membrane tubulation. However, recent data indicate that CIP4 is also involved in protrusion in some cell types, including cancer cells (lamellipodia and invadopodia) and neurons (ribbed lamellipodia and veils...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 1942–1951.
Published: 1 May 2013
... is responsible for the response. Stable lamellipodial extensions formed at the cathodal sides of wild-type cells at the start of galvanotaxis; these were absent in the ENaC knockout keratinocytes, suggesting that ENaC mediates galvanotaxis by generating stable lamellipodia that steer cell migration. We provide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5770–5780.
Published: 1 December 2012
... lamellipodium wandering around the cell perimeter, and increased lamellipodial protrusion rates. These protrusive and polarity-stabilizing effects also enabled spreading SMCs to undergo bipolar elongation to an extent not typically observed in vitro . Nampt was found to localize to lamellipodia and fluorescence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2775–2785.
Published: 1 June 2012
... branch junctions in protruding and treadmilling lamellipodia are not concentrated at the front as previously supposed, but link actin filament subsets in which there is a continuum of distances from a junction to the filament plus ends, for up to at least 1 μm. When branch sites were observed closely...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3684–3693.
Published: 15 October 2009
... the molecular mechanism by which Gal-3 stimulates cell migration. We demonstrate here that exogenous Gal-3, but not Gal-1 or Gal-8, promotes cell scattering and formation of lamellipodia in human corneal epithelial cells in a β-lactose-inhibitable manner. α3β1 integrin was identified as the major Gal-3-binding...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 1947–1953.
Published: 15 June 2009
... Actin Capping Filopodia Lamellipodia The highly related proteins of the Ena/VASP family – Mena, VASP and EVL – play pivotal roles in cell movement and shape change in vertebrates. Ena/VASP proteins are active in various cell types, including fibroblasts ( Bear et al., 2000 ), endothelial...
Journal Articles
J Cell Sci (2007) 120 (17): 3011–3021.
Published: 1 September 2007
...-VASP constructs, we found that NO produced rapid retraction of lamellipodia together with cell rounding that was dependent on guanylate cyclase and type II cGMP-dependent protein kinase. In cells expressing a mutant VASP (Ser239Ala) lacking the site preferentially phosphorylated by this kinase, NO had...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3138–3146.
Published: 1 September 2007
.... and Schwartz, M. A. ( 2001 ). Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat. Cell Biol. 3 , 316 -320. Kodaki, T., Woscholski, R., Hallberg, B., Rodriguez-Viciana, P., Downward, J. and Parker, P. J. ( 1994 ). The activation of phosphatidylinositol 3...
Includes: Multimedia, Supplementary data