... and epigenetic inactivation of E-cadherin has been strongly implicated in the development and progression of cancer. In this setting, p120 translocates to the cytosol where it exerts oncogenic properties through aberrant regulation of Rho GTPases, growth factor receptor signaling and derepression of Kaiso (also...

.... By contrast, siRNA against p120 catenin (CTNND1) also uniquely promoted proliferation of the endothelial cells by activating trafficking of p120 catenin to the nucleus, thus relieving repression by nuclear Kaiso. This nuclear p120-catenin–Kaiso signaling is associated with activation of RhoA–ROCK signaling...

... at Ser268 and Ser269, disrupting its interaction with E-cadherin. Here, we describe that Wnt-induced p120-catenin phosphorylation at Ser268 and Ser269 also enhances its binding to the transcriptional factor Kaiso, preventing Kaiso-mediated inhibition of the β-catenin–Tcf-4 transcriptional complex. Kaiso...

...Kevin F. Kelly; Abena A. Otchere; Monica Graham; Juliet M. Daniel Kaiso is a BTB/POZ transcription factor that functions in vitro as a transcriptional repressor of the matrix metalloproteinase gene matrilysin and the non-canonical Wnt signaling gene Wnt-11 , and as an activator of the acetylcholine...

...Kevin F. Kelly; Christopher M. Spring; Abena A. Otchere; Juliet M. Daniel The Armadillo catenin p120 ctn regulates cadherin adhesive strength at the plasma membrane and interacts with the novel BTB/POZ transcriptional repressor Kaiso in the nucleus. The dual localization of p120 ctn at cell-cell...

... that aberrant p120/Kaiso signaling contributes to the pleiotropic effects of cadherin loss in metastatic cells. An important possibility is that the interplay between oncogenes, catenins and nuclear signaling is responsible for tumor-cell defects associated with the contact inhibition of cell growth, a hallmark...