1-20 of 33
Keywords: JNK
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (3): jcs250340.
Published: 8 February 2021
.... Highlighted Article: Neutrophil L-selectin co-clusters with PECAM-1 in cis during transendothelial migration (TEM). Clustering neutrophil PECAM-1 activates p38 MAPK and JNK to regulate L-selectin shedding, which in turn expedites TEM. PECAM-1 Diapedesis Transmigration p38 MAPK JNK...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2020) 133 (22): jcs247353.
Published: 30 November 2020
..., -9, -13 and ADAMTS5, and cartilage matrix degradation. Mitochondrial dysfunction-induced expression of catabolic genes was dependent on the JNK (herein referring to the JNK family)/activator protein 1 (AP1) pathway but not the NFκB pathway. Scavenging of mitochondrial superoxide with MitoTEMPO...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs216101.
Published: 9 July 2018
... hippocampus. Furthermore, our findings reveal that Wnt7b and Fz7 induce the phosphorylation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and JNK proteins, which are required for dendritic development. Here, we demonstrate that Wnt7b–Fz7 signals through two non-canonical Wnt pathways to modulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs204644.
Published: 1 February 2018
... to JNK pathway inhibition. Moreover, activation of the JNK or p38 MAPK family pathway is sufficient to elicit Net1A cytosolic localization. Net1A relocalization stimulated by EGF or JNK activation requires nuclear export mediated by CRM1. JNK1 (also known as MAPK8) phosphorylates Net1A on serine 52...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2317–2328.
Published: 15 June 2016
... kinase JNK family by IRE1α late in the ER stress response promotes apoptosis. Here, we show that activation of JNK in the ER stress response precedes activation of XBP1. This activation of JNK is dependent on IRE1α and TRAF2 and coincides with JNK-dependent induction of expression of several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3411–3419.
Published: 15 September 2015
... by the attenuation of the RANKL-induced Ca 2+ oscillation, JNK activation and NFATc1 expression. In contrast, KCNK1 knockdown enhanced the RANKL-induced osteoclast differentiation, JNK activation and NFATc1 expression. In conclusion, we suggest that KCNK1 is a negative regulator of osteoclast differentiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2249–2260.
Published: 15 June 2015
... show that JNK2 has a crucial role in the G2-specific separation of the Golgi stacks through phosphorylation of Ser277 of the Golgi-stacking protein GRASP65 (also known as GORASP1). Inhibition of JNK2 by RNA interference or by treatment with three unrelated JNK inhibitors causes a potent and persistent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 656–669.
Published: 15 February 2015
... ). Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.   Biochem. J.   359 , 525 – 535 . 10.1042/0264-6021:3590525 Kontoyiannis   D. , Pasparakis   M. , Pizarro   T. T...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 527–540.
Published: 1 February 2015
... as MAPK9), to the spindle pole. However, JNK-mediated phosphorylation of WDR62 T1053 negatively regulated microtubule association, and loss of JNK signaling resulted in constitutive WDR62 localization to microtubules irrespective of cell cycle stage. In contrast, we identified that Aurora A kinase (AURKA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4134–4145.
Published: 1 October 2014
...Diana L. Douglas; Christopher P. Baines ABSTRACT Poly(ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme that can trigger caspase-independent necrosis. Two main mechanisms for this have been proposed: one involving RIP1 and JNK kinases and mitochondrial permeability transition (MPT), the other...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5670–5680.
Published: 15 December 2013
... and some highly invasive cancer cells. However, the mechanism of this assembly remains obscure. In this study, we show that the suppression of Jun N-terminal kinase (JNK) by the JNK inhibitor SP600125 or short-hairpin RNA inhibited podosome rosette formation in SrcY527F-transformed NIH3T3 fibroblasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2502–2515.
Published: 1 June 2013
...-depleted wing disc cells increases apoptosis and the number of cells that suffer from chromosome fragility. The apoptosis induced by the depletion of Dmp52 alone is partially dependent on the JNK pathway. In contrast, the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1134–1143.
Published: 1 March 2013
... suppresses the cell invasiveness and apoptotic phenotypes associated with Gliotactin overexpression. Additionally, we show that Drosophila JNK acts downstream of Gliotactin and Dlg to mediate the overgrowth and apoptosis caused by the functional interaction of Gliotactin and Dlg. Author contributions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 838–849.
Published: 1 February 2013
...Andrew Rallis; Bingwei Lu; Julian Ng Summary Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5233–5240.
Published: 1 November 2012
...) and isolated EB-derived PrE cells to investigate the mechanisms by which PINCH-1 promotes PrE survival. We report that loss of PINCH-1 in PrE cells leads to a sustained activity of JNK and the pro-apoptotic factor Bax. Mechanistically, the sustained JNK activation was due to diminished levels of the JNK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2815–2824.
Published: 15 June 2012
... ). Other viral transactivators, such as Epstein–Barr BZLF1 and BRLF1, enhance ATF2 transcriptional activities indirectly through their effect on the ATF2-phosphorylating kinases JNK or p38, whereas human vaccinia-related kinase 1 (VRK1) activates and stabilizes ATF2 through direct phosphorylation of Ser62...
Journal Articles
J Cell Sci (2012) 125 (5): 1152–1164.
Published: 1 March 2012
... (also known as Rad9) with the human paralogue Rad9B. Unlike Rad9A, overexpression of Rad9B delays cells in G1 phase. Moreover, Rad9B migrates to nucleoli after nucleolar stress in an ATR- and JNK-dependent manner, in a newly described nucleolar domain structure containing p21. Analysis of chimeras...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (23): 4052–4062.
Published: 1 December 2010
.... The apoptosis and the resulting compensatory proliferation resulting from high levels of Gliotactin are mediated by the Drosophila JNK pathway. Therefore, Gliotactin levels within the cell membrane are regulated to ensure correct protein localization and cell survival. References Ahmadian G. , Ju...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2725–2732.
Published: 15 August 2010
... to the leading edge of migrating cells, under conditions where the aPKC-exocyst control is globally abrogated. We found that activation of ERK but not JNK at focal adhesions recovers the majority of the migratory loss attributed to ERK action, demonstrating a necessary role for active plasma membrane ERK...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2651–2661.
Published: 1 August 2009
...Ulrike Resch; Yvonne M. Schichl; Gabriele Winsauer; Radhika Gudi; Kanteti Prasad; Rainer de Martin XIAP is known as a potent inhibitor of apoptosis, but in addition is involved in cellular signalling, including the NFκB, JNK and TGFβ pathways. Our search for XIAP-interacting partners led us...
Includes: Supplementary data