...Rachel Moore; Katja Vogt; Adelina E. Acosta-Martin; Patrick Shire; Martin Zeidler; Elizabeth Smythe ABSTRACT The JAK/STAT pathway is an essential signalling cascade required for multiple processes during development and for adult homeostasis. A key question in understanding this pathway is how...

...Katherine H. Fisher; Maria Fragiadaki; Dhamayanthi Pugazhendhi; Nina Bausek; Maria A. Arredondo; Sally J. Thomas; Stephen Brown; Martin P. Zeidler ABSTRACT Cytokine receptors often act via the Janus kinase and signal transducer and activator of transcription (JAK/STAT) pathway to form a signalling...

... a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired 1, Unpaired 2 and Unpaired 3 (Upd1, Upd2 and Upd3, respectively) are known to activate the JAK/STAT pathway in Drosophila . Using newly generated upd mutants and cell-specific RNAi, we showed that Upd1 is required throughout the fly...

...Olivier Devergne; Christian Ghiglione; Stéphane Noselli Domeless (Dome) is an IL-6-related cytokine receptor that activates a conserved JAK/STAT signalling pathway during Drosophila development. Despite good knowledge of the signal transduction pathway in several models, the role of receptor...