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Keywords: Intermediate filaments
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Journal Articles
J Cell Sci (2023) 136 (1): jcs260509.
Published: 3 January 2023
..., host cytoskeletal networks constantly interact with bacteria and are integral to their uptake. Vimentin, an intermediate filament protein, is one such cytoskeletal component that interacts with bacteria during infection. Although vimentin is predominantly present in the cytoplasm, it also appears...
Journal Articles
J Cell Sci (2021) 134 (15): jcs250167.
Published: 3 August 2021
...Sujin Kim; Younglan Lim; So-Young Lee; Han-Na Yoon; Hayan Yi; Kwi-Hoon Jang; Nam-On Ku ABSTRACT Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role...
Includes: Supplementary data
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Cytoskeleton
J Cell Sci (2021) 134 (6): jcs256156.
Published: 22 March 2021
... 1 2021 © 2021. Published by The Company of Biologists Ltd 2021 Highlighted Article: The lamin A/C H222P laminopathy mutation provides insights into lamin substructure organization. Cryo-electron tomography Intermediate filaments Lamins Nuclear lamins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs250597.
Published: 5 November 2020
...Yue Zhang; Zeyu Wen; Xuemeng Shi; Yan-Jun Liu; John E. Eriksson; Yaming Jiu ABSTRACT Epidemics caused by viral infections pose a significant global threat. Cytoskeletal vimentin is a major intermediate filament (IF) protein, and is involved in numerous functions, including cell signaling...
Journal Articles
J Cell Sci (2020) 133 (14): jcs243956.
Published: 29 July 2020
...Sachiko Fujiwara; Shinji Deguchi; Thomas M. Magin ABSTRACT Keratin intermediate filament (IF) proteins constitute the major cytoskeletal components in epithelial cells. Missense mutations in keratin 5 (K5; also known as KRT5) or keratin 14 (K14; also known as KRT14), highly expressed in the basal...
Includes: Supplementary data
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (15): 2541–2550.
Published: 1 August 2017
... filament organization and delays apoptosis, thereby protecting liver from injury. Keratin Intermediate filaments Liver Apoptosis Caspase Cell integrity Protein stability Keratin 8 and keratin 18 (KRT8 and KRT18, respectively; hereafter referred to as K8/K18) in the liver are a pair...
Includes: Supplementary data
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Imaging
J Cell Sci (2014) 127 (16): 3568–3577.
Published: 15 August 2014
... the control of NF-κB signaling. This kinase is post-translationally regulated through Hsp70-mediated refolding. Previous work has shown that such a chaperoning activity is specifically localized to keratin intermediate filaments. Our work was performed with the goal of identifying the molecule(s) that block...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2161–2173.
Published: 15 May 2014
...Claire L. Hyder; Glorianne Lazaro; Joanna W. Pylvänäinen; Maxwell W. G. Roberts; Susanna M. Qvarnström; John E. Eriksson ABSTRACT Nestin, an intermediate filament protein and marker of undifferentiated cells, is expressed in several cancers. Nestin is important for neuronal survival...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2012) 125 (9): 2148–2159.
Published: 1 May 2012
... filaments and microtubules in cell motility is well established, the role of intermediate filaments in this process is incompletely understood. Organization and structure of the keratin cytoskeleton, which consists of heteropolymers of at least one type 1 and one type 2 intermediate filament, are in part...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1750–1758.
Published: 1 April 2012
...Lee Wallace; Leiann Roberts-Thompson; Julia Reichelt Keratins K1 and K10 are the most abundant proteins in the upper epidermis where they polymerize to form intermediate filaments (IFs). In addition to their well-established function in providing epidermal stability, K1/K10 (i.e. the dimer between...
Journal Articles
J Cell Sci (2011) 124 (20): 3464–3476.
Published: 15 October 2011
...Gloria M. Conover; Carol C. Gregorio Desmin intermediate filaments intimately surround myofibrils in vertebrate muscle forming a mesh-like filament network. Desmin attaches to sarcomeres through its high-affinity association with nebulin, a giant F-actin binding protein that co-extends along...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2010) 123 (15): 2543–2552.
Published: 1 August 2010
...W. Thomas Clarke; Ben Edwards; Karl J. A. McCullagh; Matthew W. Kemp; Catherine Moorwood; Diane L. Sherman; Matthew Burgess; Kay E. Davies Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3851–3855.
Published: 1 November 2009
... ) 25 8 2009 © The Company of Biologists Limited 2009 2009 Intermediate filaments Keratin 8 Keratin 18 Cytoprotection Mitochondria Liver injury Apoptosis Cytochrome c release Oxidative stress Intermediate filaments (IFs), actin-containing microfilaments and microtubules...
Includes: Supplementary data
Journal Articles