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Keywords: Integrin
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Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (11): jcs259465.
Published: 6 June 2022
...Alba Zuidema; Wei Wang; Maaike Kreft; Onno B. Bleijerveld; Liesbeth Hoekman; Jonas Aretz; Ralph T. Böttcher; Reinhard Fässler; Arnoud Sonnenberg ABSTRACT The vitronectin receptor integrin αVβ5 can reside in two distinct adhesion structures – focal adhesions (FAs) and flat clathrin lattices (FCLs...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (9): jcs259579.
Published: 6 May 2022
... thought to prevent binding in unfavorable locations by countering the weak adhesion of L-selectin ( Ochoa-Bernal and Fazleabas, 2020 ). Removal of MUC-1 by cleavage at the site of implantation enables strong adhesion. Additionally, integrins, dystroglycan 1 (DAG1) and trophinin mediate robust adhesion...
Journal Articles
In collection:
Cell Migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
... at the leading and lagging edge of migrating cells. We find that cells lacking ALFY have reduced attachment and altered protein levels and glycosylation of integrins, resulting in the inability to form a proper leading edge and loss of directional cell motility. Manual tracking of cells from the wound healing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (22): jcs259040.
Published: 26 November 2021
...Sarah Klapproth; Karsten Richter; Clara Türk; Theresa Bock; Thomas Bromberger; Julian Dominik; Kathrin Huck; Kristian Pfaller; Michael W. Hess; Christoph A. Reichel; Marcus Krüger; Inaam A. Nakchbandi; Markus Moser ABSTRACT Osteoclasts form special integrin-mediated adhesion structures called...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (20): jcs258749.
Published: 28 October 2021
...Benjamin T. Goult; Nicholas H. Brown; Martin A. Schwartz ABSTRACT Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs259004.
Published: 15 September 2021
... to the underlying basement membrane. Integrin α6β4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, α6β4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (16): jcs258602.
Published: 27 August 2021
...Keith P. Eidell; Alenka Lovy; Nicholas R. Sylvain; Frank A. Scangarello; Hayley I. Muendlein; Michael J. Ophir; Ken Nguyen; Maria-Cristina Seminario; Stephen C. Bunnell ABSTRACT Integrin engagement within the immune synapse enhances T cell activation, but our understanding of this process...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (8): jcs256115.
Published: 20 April 2021
...Wenting Bu; Zarina Levitskaya; Suet-Mien Tan; Yong-Gui Gao ABSTRACT Integrin-mediated cell–extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. Kindlins are important positive regulators of integrin activation. The FERM-domain...
Journal Articles
J Cell Sci (2020) 133 (23): jcs242461.
Published: 11 December 2020
...Farhana A. Sarker; Victoria G. Prior; Samuel Bax; Geraldine M. O'Neill ABSTRACT Research throughout the 90s established that integrin crosstalk with growth factor receptors stimulates robust growth factor signaling. These insights were derived chiefly from comparing adherent versus suspension cell...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (20): jcs248823.
Published: 2 November 2020
... by mechanical forces transmitted across cell surface β1 integrin receptors on endothelial cells, and the transmembrane solute carrier family 3 member 2 (herein denoted CD98hc, also known as SLC3A2) protein has been implicated in this response. Here, we show that β1 integrin, CD98hc and TRPV4 all tightly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs239202.
Published: 12 October 2020
...; Jinhua Wu; Vesa P. Hytönen; Bernhard Wehrle-Haller ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs238840.
Published: 10 July 2020
... the mechanics of adhesion, we employed tension gauge tether (TGT) probes displaying the integrin ligand cRGDfK and quantified integrin tension. EGF exposure significantly increased spread area, cell circularity, integrated integrin tension, mechanical rupture density, radial organization and size of focal...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (11): jcs246595.
Published: 11 June 2020
...Hao Xu; Kevin Pumiglia; Susan E. LaFlamme ABSTRACT During angiogenesis, endothelial cells engage components of the extracellular matrix through integrin-mediated adhesion. Endothelial expression of laminin-411 and laminin-511 is known to promote vessel stability. However, little is known about...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs239152.
Published: 14 May 2020
... to sites of ECM remodeling. Internalization of MT1-MMP is dependent on its phosphorylation, and here we examine the role of β1 integrin-mediated signaling in this process. Activation of β1 integrin using the antibody P4G11 induced phosphorylation and internalization of MT1-MMP and resulted in increased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs236778.
Published: 28 April 2020
...- and adhesion-independent manner. Here, we delineate a contractility-dependent migratory mode of primarily round breast cancer cells that is associated with extensive integrin-mediated extracellular matrix (ECM) reorganization that occurs at membrane blebs, with bleb necks sites of integrin clustering...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs241794.
Published: 21 April 2020
... clear data showing that atypical basement membranes are quite prevalent and that even typical planar basement membranes harbor a lot of diversity that we do not comprehend yet. Collagen IV Drosophila Extracellular matrix Fibrosis Integrin Tissue morphogenesis Multicellular organisms...
Journal Articles
J Cell Sci (2020) 133 (3): jcs239947.
Published: 12 February 2020
... to drive DLC1 expression. DLC1 is needed to limit F-actin fiber formation, integrin-based focal adhesion lifetime and integrin-mediated traction forces. Depletion of endothelial DLC1 strongly perturbs cell polarization in directed collective migration and inhibits the formation of angiogenic sprouts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs235531.
Published: 1 November 2019
...Thomas Bromberger; Liang Zhu; Sarah Klapproth; Jun Qin; Markus Moser ABSTRACT Recruitment and tethering of talin to the plasma membrane initiate the process of integrin activation. Multiple factors including the Rap1 proteins, RIAM (also known as APBB1IP) and PIP 2 bind talin proteins and have been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs232439.
Published: 16 October 2019
...Chen Yu; Luis E. Muñoz; Mallika Mallavarapu; Martin Herrmann; Silvia C. Finnemann ABSTRACT Diurnal clearance phagocytosis by the retinal pigment epithelium (RPE) is a conserved efferocytosis process whose binding step is mediated by αvβ5 integrin receptors. Two related annexins, A5 (ANXA5) and A6...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2019) 132 (19): jcs235366.
Published: 10 October 2019
...Lisa te Molder; Juri Juksar; Rolf Harkes; Wei Wang; Maaike Kreft; Arnoud Sonnenberg ABSTRACT Tetraspanin CD151 has been suggested to regulate cell adhesion through its association with laminin-binding integrins α3β1 and α6β4; however, its precise function in keratinocyte adhesion remains elusive...
Includes: Supplementary data