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Keywords: Insulin
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Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (5): jcs258734.
Published: 12 August 2021
... to the capillary lumen. LPL secretion is regulated by insulin in adipose tissue; however, few studies have examined the regulatory and trafficking steps involved in secretion. Here, we describe the intracellular localization and insulin-dependent trafficking of LPL in 3T3-L1 adipocytes. We compared LPL trafficking...
Includes: Supplementary data
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Mitochondria
J Cell Sci (2019) 132 (9): jcs228544.
Published: 30 April 2019
...Nadine Griesche; Gonzalo Sanchez; Cedric Hermans; Olof Idevall-Hagren ABSTRACT Mitochondria play an essential role in regulating insulin secretion from beta cells by providing the ATP needed for the membrane depolarization that results in voltage-dependent Ca 2+ influx and subsequent insulin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs216127.
Published: 7 September 2018
... an accumulation of enlarged autophagic vesicles resulting in part from a failure to deliver lysosomal hydrolases, rendering autolysosomes with a reduced degradative capacity and impaired turnover. Additionally, Rab6-deficient cells are reduced in size and display defective insulin–TOR signaling as a result of mis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2757–2766.
Published: 15 August 2017
... to discern Akt localisation, yet it has not been clear how well these tools recapitulate the behaviour of endogenous Akt proteins. Here, we observed that fusion of eGFP to Akt2 impaired both its insulin-stimulated plasma membrane recruitment and its phosphorylation. Endogenous-like responses were restored...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 541–550.
Published: 1 February 2017
...-stimulated insulin secretion. Although knockdown of any component of the ternary complex markedly inhibits insulin secretion, only knockdown of Rab2a or Noc2, and not that of Rab27a, impairs cargo processing from proinsulin to insulin. These results suggest that the dual effector, Noc2, regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 143–151.
Published: 1 January 2017
... , K. , Eliasson , L. , Ammala , C. , Renstrom , E. and Rorsman , P. ( 1995 ). Colocalization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic beta-cells . EMBO J.   14 , 50 - 57...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (11): 2273–2284.
Published: 1 June 2016
... in adipocytes. In contrast, the same loop of GLUT1 was without effect. The reporter molecules to which the first loop of GLUT4 was fused localized, unlike GLUT4, to the trans-Golgi network (TGN), possibly explaining why these molecules did not respond to insulin. The retention induced by the GLUT4 loop...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2013) 126 (9): 1931–1941.
Published: 1 May 2013
...Sam E. Reed; Lorna R. Hodgson; Shuang Song; Margaret T. May; Eoin E. Kelly; Mary W. McCaffrey; Cynthia C. Mastick; Paul Verkade; Jeremy M. Tavaré Summary Insulin enhances the uptake of glucose into adipocytes and muscle cells by promoting the redistribution of the glucose transporter isoform 4...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 1 December 2012
.... Published by The Company of Biologists Ltd 2012 Metabolism Stem cells ESCs Reprogramming iPSCs HSCs NSCs AMPK FOXO mTOR SIRT1 Insulin Hypoxia Aging Stem cells serve as the origin for all tissues during embryonic and postnatal development, and contribute to tissue homeostasis...
Journal Articles
J Cell Sci (2011) 124 (5): 801–811.
Published: 1 March 2011
...Jimena Giudice; Federico Coluccio Leskow; Donna J. Arndt-Jovin; Thomas M. Jovin; Elizabeth A. Jares-Erijman Insulin signaling comprises a complex cascade of events, playing a key role in the regulation of glucose metabolism and cellular growth. Impaired response to insulin is the hallmark...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 13–22.
Published: 1 January 2010
... is recruited to the plasma membrane in response to insulin and is targeted to substrates by forming transient holoenzyme complexes that have different specificities. Cytosolic O -GlcNAcylation is important for the proper transduction of signaling cascades such as the NFκB pathway, whereas nuclear O -GlcNAc...
Journal Articles
J Cell Sci (2009) 122 (6): 775–779.
Published: 15 March 2009
... this affects native currents and cellular excitability remains to be determined. The voltage-dependent K + (Kv) channel Kv2.1 regulates pancreatic β-cell excitability and insulin secretion. We found that YFP-tagged SUMO1 (SUMO1-YFP) can be immunoprecipitated with Kv2.1 when these two proteins are coexpressed...
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