...-H3K27me2/3 in cancers resulting from genome instability by inefficient DSB repair. Histone methylation H3K27me3 H3K27M NHEJ FANCD2 Genome stability Over the past few decades, accumulating evidence has supported a critical role for aberrant epigenetic regulation and alterations in histone...

... by overexpression of Trx H3K4 methylase in Drosophila . TrxG PcG Histone methylation Drosophila A myriad of epigenetic factors, defined initially in Drosophila as the Polycomb group (PcG) repressors and trithorax group (trxG) activators ( Jürgens, 1985 ; Kennison and Tamkun, 1988 ), act...

... Histone methylation Transcription regulation NF-κB signaling pathway The epigenetic control of chromatin is crucial for transcription regulation and the proper response to extracellular signals in the cell. The polycomb repressive complexes 1 and 2 (PRC1 and PRC2) are the most studied protein...

... or financial interests. 2 6 2015 5 1 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: KDM6-specific H3K27me3 demethylase activity is crucially involved in the DNA damage response and survival of differentiating ESCs. Histone methylation Polycomb Histone...

... containing Cdt2). However, the factors involved in positive regulation of PrSet7 histone methylation remain undefined. Here, we present biochemical and genetic evidence for a previously undocumented interaction between Drosophila PrSet7 (dPrSet7) and DNA polymerase α in Drosophila . Depletion...

... contributed equally to this work ‡ Authors for correspondence ( wumin@whu.edu.cn ; lilianyun@whu.edu.cn ) 29 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 MLL1 MLL Histone methylation Transcription regulation NF-κB signaling pathway MLL1 (mixed lineage...

... in embryonic stem cells . Cell 125 , 315 - 326 . Biron V. L. , McManus K. J. , Hu N. , Hendzel M. J. , Underhill D. A. ( 2004 ). Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development . Dev. Biol. 276 , 337 - 351 . Bongiorni...

... Limited 2009 2009 Chromatin Heterochromatin Histone methylation HP1 Nuclear organisation Transcriptional repression Zinc-finger proteins (ZFPs) that contain the Krüppel-associated box (KRAB) domain comprise the largest single family of transcriptional regulators in the mammalian genome...

... proteins, and thereby regulate their function. Arginine methylation Subcellular localization and dynamics Posttranslational modification Histone methylation Epigenetics © The Company of Biologists Limited 2009 2009 17 11 2008 * Author for correspondence (e-mail: frank...

...@staff.uni-marburg.de ) * Present address: EMBL, Heidelberg, Germany 14 3 2007 © The Company of Biologists Limited 2007 2007 Drosophila Histone acetylation Histone methylation Histone ubiquitylation Transition protein Protamine CTCF DNA breaks Rad6 UbcD6 RNA polymerase...

... and Ruiz, 2002 ). We here investigated histone methylation modifications between chromosomes in germline cells of Sciara ocellaris . In early germ nuclei, maternal chromosomes show high levels of di- and trimethylated histone H3 at Lys4, whereas this histone modification is not detected in paternal...

... on histone H3 by the HP1 chromo domain. Nature 410 , 120 -124. Bannister, A. J., Schneider, R. and Kouzarides, T. ( 2002 ). Histone methylation: dynamic or static? Cell 109 , 801 -806. Brehm, A. and Kouzarides, T. ( 1999 ). Retinoblastoma protein meets chromatin. Trends Biochem. Sci. 24...