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Keywords: Histone methylation
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Journal Articles
J Cell Sci (2023) 136 (21): jcs261406.
Published: 3 November 2023
... H3K36me3 in vivo , enabling the divergent roles of SETD2 in tubulin and histone methylation to be parsed. Homozygous mice showed embryonic lethality, but heterozygous mice were viable and displayed an anxiety-like phenotype. Primary neurons cultured from the cortex and hippocampus of the heterozygous mice...
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (9): jcs210179.
Published: 9 May 2018
... by overexpression of Trx H3K4 methylase in Drosophila . TrxG PcG Histone methylation Drosophila A myriad of epigenetic factors, defined initially in Drosophila as the Polycomb group (PcG) repressors and trithorax group (trxG) activators ( Jürgens, 1985 ; Kennison and Tamkun, 1988 ), act...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2343–2353.
Published: 15 June 2016
... genes. EZH1 UXT Histone methylation Transcription regulation NF-κB signaling pathway The epigenetic control of chromatin is crucial for transcription regulation and the proper response to extracellular signals in the cell. The polycomb repressive complexes 1 and 2 (PRC1 and PRC2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 788–803.
Published: 15 February 2016
... for rapid transcriptional activation or repression ( Bernstein et al., 2006 ). Histone methylation Polycomb Histone demethylase DNA damage Embryonic stem cells Differentiation Summary: KDM6-specific H3K27me3 demethylase activity is crucially involved in the DNA damage response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3066–3078.
Published: 15 July 2014
... containing Cdt2). However, the factors involved in positive regulation of PrSet7 histone methylation remain undefined. Here, we present biochemical and genetic evidence for a previously undocumented interaction between Drosophila PrSet7 (dPrSet7) and DNA polymerase α in Drosophila . Depletion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 4058–4066.
Published: 1 September 2012
.... , Cui   K. , Roh   T. Y. , Schones   D. E. , Wang   Z. , Wei   G. , Chepelev   I. , Zhao   K. ( 2007 ). High-resolution profiling of histone methylations in the human genome.   Cell   129 , 823 – 837 . 10.1016/j.cell.2007.05.009 Baud   V. , Karin   M. ( 2009...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1878–1890.
Published: 1 June 2011
... Heterochromatin Histone methylation Advances in histone modification mapping have revealed that different histone signatures are associated with various chromatin states. In accordance with a loosely defined histone code, prevalent combinations of modifications have been found to demarcate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 937–946.
Published: 1 April 2009
... 11 2008 © The Company of Biologists Limited 2009 2009 Chromatin Heterochromatin Histone methylation HP1 Nuclear organisation Transcriptional repression Zinc-finger proteins (ZFPs) that contain the Krüppel-associated box (KRAB) domain comprise the largest single family...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 667–677.
Published: 1 March 2009
...-mail: frank@fackelmayer.de ) 17 11 2008 © The Company of Biologists Limited 2009 2009 Arginine methylation Subcellular localization and dynamics Posttranslational modification Histone methylation Epigenetics Post-translational modification of proteins is an important means...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (9): 1689–1700.
Published: 1 May 2007
... of lysine 4 of histone H3 indicates activation. Histone lysines can be mono-, di- or trimethylated ( Lachner et al., 2003 ). Post-meiotic germ cells of Drosophila are virtually completely transcriptionally silent (for a review, see Renkawitz-Pohl et al., 2005 ); thus, histone methylation on lysine...
Journal Articles
J Cell Sci (2006) 119 (22): 4667–4677.
Published: 15 November 2006
... and Ruiz, 2002 ). We here investigated histone methylation modifications between chromosomes in germline cells of Sciara ocellaris . In early germ nuclei, maternal chromosomes show high levels of di- and trimethylated histone H3 at Lys4, whereas this histone modification is not detected in paternal...
Journal Articles
J Cell Sci (2004) 117 (11): 2173–2181.
Published: 1 May 2004
... Cell cycle Transcription repression Histone acetylation Histone methylation The retinoblastoma tumor suppressor protein (pRB) and its relatives, p107 and p130, are negative regulators of cell proliferation that figure prominently in most models of cell-cycle control. Cell-cycle progression...