.... and Greaser , M. L. ( 2010 ). Titin diversity—alternative splicing gone wild . J. Biomed. Biotechnol. 2010 , 753675 . 10.1155/2010/753675 Gupta , M. P. ( 2007 ). Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure . J. Mol. Cell Cardiol. 43...

... by CRYAB ), and the fact that mutations in either one of them leads to heart failure in humans and mice, suggests a potential compensatory interplay between the two in cardioprotection. To address this hypothesis, we investigated the consequences of αΒ-crystallin overexpression in the desmin-deficient...

... in RyR2 pathophysiology and cardiac disease. * Author for correspondence ( zissimopouloss@cf.ac.uk ) 17 11 2011 © 2012. 2012 Ryanodine receptor FK506-binding protein Cardiac muscle Heart failure Arrhythmias Ryanodine receptors (RyRs) are tetrameric intracellular Ca 2...

... in heart function is also unknown. Using reverse genetics in zebrafish, we demonstrated that inactivation of the highly conserved zebrafish orthologue of ORAI1 resulted in severe heart failure, reduced ventricular systolic function, bradycardia and skeletal muscle weakness. Electron microscopy of Orai1...

... signals. Mutations in genes encoding different Z-disc proteins such as integrin-linked kinase (ILK) and nexilin have recently been shown to cause heart failure by distinct mechanisms such as disturbed mechanosensing, altered mechanotransduction or mechanical Z-disc destabilization. We identified core...