.... , Galda , S. N. , Sengupta , S. , Mahoney , S. J. , Howell , J. J. , Molz , L. , Hahm , S. , et al. ( 2019 ). Discovery of small-molecule selective mTORC1 inhibitors via direct inhibition of glucose transporters . Cell Chem Biol.   26 , 1203 - 1213.e13 . 10.1016/j.chembiol...

...Renzhong Li; Tony Wang; Khyati Walia; Bo Gao; Joan C. Krepinsky ABSTRACT Glomerular matrix accumulation is the hallmark of diabetic nephropathy. The metalloprotease ADAM17 mediates high glucose (HG)-induced matrix production by kidney mesangial cells through release of ligands for the epidermal...

... on primary cilium formation. Glucose deprivation significantly increased the number of ciliated cells under both serum-fed and -starved conditions. Glucose deprivation-induced ciliogenesis was suppressed by overexpression of Rheb, an activator of the mammalian target of rapamycin complex-1 (mTORC1...

..., we studied the mechanism of this homeostatic phenomenon in C2C12 myoblasts. Acute (30 min) mitoenergetic dysfunction induced by the mitochondrial inhibitors piericidin A and antimycin A stimulated Glut1-mediated glucose uptake without altering Glut1 (also known as SLC2A1) mRNA or plasma membrane...

.... In order to get quantitative information about the size of lipid droplets and the shape of mitochondria under growth in glucose and oleate ( Fig. S1A–E ), an in-house script was written in ImageJ ( http://imagej.net/Fiji/Downloads ), which includes a rolling ball algorithm for subtracting the background...

... by phospholipase C (PLC)-activating receptor agonists or stimulatory glucose concentrations was paralleled by increased PtdIns(4) P levels. In addition, glucose-stimulated cells regularly showed anti-synchronous oscillations of the two lipids. Whereas glucose-induced PtdIns(4) P elevation required voltage-gated Ca...

...Gavin I. Welsh; Sophie E. Leney; Bethan Lloyd-Lewis; Matthew Wherlock; Andrew J. Lindsay; Mary W. McCaffrey; Jeremy M. Tavaré The translocation of GLUT4 to the plasma membrane underlies the ability of insulin to stimulate glucose uptake, an event that involves the activation of protein kinase B...

...Florent Allagnat; David Martin; Daniele F. Condorelli; Gérard Waeber; Jacques-Antoine Haefliger The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose...

... skeletal muscle. Here, we assessed whether glucose could regulate gene expression in contracting myotubes deriving from cultured muscle satellite cells. Glucose uptake increased twofold after a 30 minute treatment with a high glucose concentration, suggesting an acute glucose-stimulated glucose uptake...

...Aniko Varadi; Edward K. Ainscow; Victoria J. Allan; Guy A. Rutter Recruitment of secretory vesicles to the cell surface is essential for the sustained secretion of insulin in response to glucose. At present, the molecular motors involved in this movement, and the mechanisms whereby they may...

...Kay Barnes; Jean C. Ingram; Omar H. Porras; L. Felipe Barros; Emma R. Hudson; Lee G. D. Fryer; Fabienne Foufelle; David Carling; D. Grahame Hardie; Stephen A. Baldwin In the rat liver epithelial cell line Clone 9, the V max for glucose uptake is actuely increased by inhibition of oxidative...