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Keywords: Glioma
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Journal Articles
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J Cell Sci (2021) 134 (22): jcs259188.
Published: 24 November 2021
...Shruti Patrick; Pruthvi Gowda; Kirti Lathoria; Vaishali Suri; Ellora Sen ABSTRACT Mutation of the isocitrate dehydrogenase 1 ( IDH1 ) gene leads to the production of oncometabolite D-2-hydroxyglutarate (2-HG) from α-ketoglutarate and is associated with better prognosis in glioma. As Yes-associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs225714.
Published: 4 March 2019
... mouse model, differential YAP expression in glioma cells promotes tumorigenesis and leads to clonal dominance by cells expressing more YAP. Such clonal dominance also occurs in vitro when cells reach confluence in the two-dimensional culture condition or grow into tumor spheroids. During this process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 71–82.
Published: 1 January 2017
..., are reviewed. Glioma Mechanobiology Mechanotransduction Microenvironment Neurodegeneration Differentiated tissues exhibit distinct mechanical properties ( Fig. 1 ), which direct their structure and function and reflect the composition and architecture of the extracellular matrix (ECM...
Journal Articles
J Cell Sci (2014) 127 (17): 3687–3698.
Published: 1 September 2014
... is established; however, their role in non-neuronal cells is poorly defined. As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells. Human brain tumor biopsies selectively expressed the GlyR α1 and α3 subunits, which have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 722–731.
Published: 1 February 2013
... (ANOVA) and Bonferroni or Dunnett multiple comparison tests. P <0.05 was considered significant. We thank R. Biervig (University of Bergen, Norway) for providing the U251 malignant glioma cell line, J. Bonifacino (NIH, USA) for the GST-GGA3 construct, and D. Colman (Montreal Neurological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4343–4353.
Published: 15 September 2012
....   Biochem. Biophys. Res. Commun.   320 , 1063 – 1068 . 10.1016/j.bbrc.2004.06.067 Jung   S. , Paek   Y. W. , Moon   K. S. , Wee   S. C. , Ryu   H. H. , Jeong   Y. I. , Sun   H. S. , Jin   Y. H. , Kim   K. K. , Ahn   K. Y. ( 2006 ). Expression of Nm23 in gliomas...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 844–857.
Published: 15 February 2012
... in human glioma samples and purified glioma cells. Using a wound-healing assay, we show that a decreased level of N-cadherin promotes a faster and less-directed migration both in normal and tumour cells. N-cadherin-mediated contacts control cell velocity and polarity through the regulation of focal...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (3): 290–297.
Published: 1 February 2008
... to initiators of apoptosis or whether it is functionally significant is not clear. In this study, we sought to answer this question using human malignant glioma cells as a model system. In vivo, high grade gliomas demonstrate an increased percentage of apoptotic cells as well as upregulation of death ligand...
Journal Articles
J Cell Sci (2003) 116 (21): 4409–4417.
Published: 1 November 2003
...Anna M. Joy; Christian E. Beaudry; Nhan L. Tran; Francisco A. Ponce; David R. Holz; Tim Demuth; Michael E. Berens Glioma cells that migrate out of the main tumor mass into normal brain tissue contribute to the failure of most gliomas to respond to treatment. Treatments that target migratory glioma...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (14): 2845–2855.
Published: 15 July 2003
..., and suggest that they may be part of the focal adhesion kinase regulatory complex. * Author for correspondence (e-mail: oliver@bogler.net ) 31 3 2003 © The Company of Biologists Limited 2003 2003 Glioma Astrocytes SETA/CIN85/Ruk AIP1 Focal adhesion kinase Cytoskeleton Electrical...
Journal Articles
J Cell Sci (2002) 115 (2): 283–292.
Published: 15 January 2002
..., however, are poorly elucidated. We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCAM interactions. Expression of the transmembrane 140 kDa isoform of NCAM (NCAM-140) caused...