...Ronen Zaidel-Bar; Ron Milo; Zvi Kam; Benjamin Geiger Diverse cellular processes are carried out by distinct integrin-mediated adhesions. Cell spreading and migration are driven by focal complexes; robust adhesion to the extracellular matrix by focal adhesions; and matrix remodeling by fibrillar...

... Limited 2005 2005 Actin cytoskeleton Fibronectin Staphylococci Focal complexes Focal adhesion kinase Cortactin Integrins are heterodimeric surface receptors of multicellular organisms critically involved in cell-cell and cell-matrix adhesion. In addition to their structural role...

... complexes, formed under the leading lamellae of motile cells, and their maturation into focal adhesions. We combined phase-contrast and fluorescence microscopy approaches to monitor the incorporation of phosphotyrosine and nine different focal adhesion proteins into focal complexes in endothelial cells...

... interacting with a fibrillar extracellular matrix. * Author for correspondence (e-mail: matthew.petroll@utsouthwestern.edu ) 7 1 2003 © The Company of Biologists Limited 2003 2003 Focal adhesions Focal complexes Cell motility Collagen lattice Actomyosin Cell mechanics...

... the regulation of the recently identified group II PAKs(PAK4-6). Here we report that PAK4 is activated by HGF, a migratory stimulus for epithelial cells. In unstimulated MDCK cells, activated PAK4 induces a decrease in stress fibres, and when cells are stimulated with HGF, it induces a loss of focal complexes...

..., integrins defective in forming peripheral focal complex structures was unable to mediate uptake of invasin-expressing bacteria. References Alrutz, M. A. and Isberg, R. R. ( 1998 ). Involvement of focal adhesion kinase in invasin-mediated uptake. Proc. Natl. Acad. Sci. USA 95 , 13658 -13663...