... reveal different modes of response to variations in the level of ARNT in vitro: basal keratins K5 and K14 showed no sensitivity at all; suprabasal differentiation markers such as K1/10, TGM1 and involucrin were induced by ARNT deficiency at both mRNA (moderately) and protein levels; while filaggrin...

...), a retinoic-acid-degrading enzyme, results in aberrant epidermal differentiation and filaggrin expression, defective cornified envelopes and skin barrier formation, in conjunction with peridermal retention. We show that these alterations are RA dependent because administration of exogenous RA in vivo...

... envelope proteins involucrin, loricrin, filaggrin, and of the keratins K1 and K5 were significantly altered in cathepsin D-deficient mice. Stratum corneum morphology in cathepsin D-deficient mice was impaired, with increased numbers of corneocyte layers and faint staining of the cornified envelope only...