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Keywords: FIH
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Journal Articles
J Cell Sci (2018) 131 (22): jcs219782.
Published: 19 November 2018
... factors (HIFs), whose stability and subsequent transcriptional activation are regulated by HIF hydroxylases. Factor inhibiting HIF (FIH), initially isolated as a HIFα interacting protein following a yeast two-hybrid screen, is an asparaginyl hydroxylase that negatively regulates transcriptional activation...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (6): 1454–1463.
Published: 15 March 2013
...-hydroxylases. We predict from our model (and confirm experimentally) that there is residual activity of the asparaginyl-hydroxylase FIH (factor inhibiting HIF) at low oxygen tension. Furthermore, silencing FIH under conditions where prolyl-hydroxylases are inhibited results in increased HIF-1α transcriptional...
Includes: Supplementary data