...Alaina H. Willet; Maya G. Igarashi; Jun-Song Chen; Rahul Bhattacharjee; Liping Ren; Sierra N. Cullati; Zachary C. Elmore; Rachel H. Roberts-Galbraith; Alyssa E. Johnson; Janel R. Beckley; Kathleen L. Gould ABSTRACT The F-BAR protein Imp2 is an important contributor to cytokinesis in the fission...

...Rebeca Martín-García; Pedro M. Coll; Pilar Pérez ABSTRACT F-BAR domain proteins act as linkers between the cell cortex and cytoskeleton, and are involved in membrane binding and bending. Rga7 is one of the seven F-BAR proteins present in the fission yeast Schizosaccharomyces pombe . In addition...

...Witchuda Saengsawang; Kendra L. Taylor; Derek C. Lumbard; Kelly Mitok; Amanda Price; Lauren Pietila; Timothy M. Gomez; Erik W. Dent Summary Cdc42-interacting protein 4 (CIP4), a member of the F-BAR family of proteins, plays important roles in a variety of cellular events by regulating both membrane...

... a suppressing function of dia on membrane invaginations. Dia function might be based on an antagonistic interaction with the F-BAR protein Cip4/Toca-1, a known activator of the WASP/WAVE-Arp2/3 pathway. Dia and Cip4 physically and functionally interact and overexpression of Cip4 phenocopies dia loss-of-function...

... role of srGAP3 on actin dynamics, specifically on lamellipodia formation. We show that the F-BAR domain localizes srGAP3 to the leading edge of cellular protrusions whereas the SH3 domain is important for focal adhesion targeting. We report on a novel srGAP3 interaction partner, lamellipodin, which...

.... Here, we show that Rac1 associates, through its C-terminus, with the F-BAR domain protein PACSIN2, an inducer of membrane tubulation and a regulator of endocytosis. We show that Rac1 localizes with PACSIN2 at intracellular tubular structures and on early endosomes. Active Rac1 induces a loss of PACSIN2...

...Sean M. Hartig; Shuhei Ishikura; Rachel S. Hicklen; Yanming Feng; Elisabeth G. Blanchard; Kevin A. Voelker; Christina S. Pichot; Robert W. Grange; Robert M. Raphael; Amira Klip; Seth J. Corey F-BAR proteins are a newly described family of proteins with unknown physiological significance. Because F...

...Robert J. W. Heath; Robert H. Insall PCH family proteins are fundamentally important proteins, linking membrane curvature events with cytoskeletal reorganisation. One group, the MEGAPs (also called srGAPs and WRPs) contain RhoGAP domains in addition to the F-BAR domain. We disrupted MEGAP1...