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Keywords: Extracellular matrix
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Journal Articles
J Cell Sci (2022) 135 (20): jcs259900.
Published: 19 October 2022
...Vinay Kumar Dubey; Souradeep R. Sarkar; Vairavan Lakshmanan; Rimple Dalmeida; Akash Gulyani; Dasaradhi Palakodeti ABSTRACT Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (19): jcs260094.
Published: 12 October 2022
...Xuekai Xiong; Weini Li; Jin Nam; Meng Qu; Steve A. Kay; Ke Ma ABSTRACT The circadian clock is entrained to daily environmental cues. Integrin-linked signaling via actin cytoskeleton dynamics transduces physical niche cues from the extracellular matrix to myocardin-related transcription factor (MRTF...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (9): jcs259579.
Published: 6 May 2022
... by either cell–extracellular matrix adhesion or cell–cell adhesion, and both the mechanisms and consequences of inter-tissue adhesion have been studied in vivo in numerous vertebrate and invertebrate species. In this Review, we discuss recent progress in understanding the many functions of inter-tissue...
Journal Articles
J Cell Sci (2022) 135 (1): jcs258879.
Published: 13 January 2022
...John Hellicar; Nicola L. Stevenson; David J. Stephens; Martin Lowe ABSTRACT The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
.... Introducing leukocytes into the vessels allowed real-time visualization of all different steps of the leukocyte transmigration cascade, including migration into the extracellular matrix. Individual cell tracking over time distinguished striking differences in migratory behaviour between T-cells...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
.../physrev.00018.2013 Bonnans , C. , Chou , J. and Werb , Z. ( 2014 ). Remodelling the extracellular matrix in development and disease . Nat. Rev. Mol. Cell Biol. 15 , 786 - 801 . 10.1038/nrm3904 Burridge , K. ( 2017 ). Focal adhesions: a personal perspective...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (8): jcs256115.
Published: 20 April 2021
...Wenting Bu; Zarina Levitskaya; Suet-Mien Tan; Yong-Gui Gao ABSTRACT Integrin-mediated cell–extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. Kindlins are important positive regulators of integrin activation. The FERM-domain...
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (4): jcs252957.
Published: 24 February 2021
... and provide a first step for the development of a generative model of FN networks to unravel assembly mechanisms and investigate the physical and functional versatility of extracellular matrix landscapes. This article has an associated First Person interview with the first author of the paper...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247189.
Published: 24 December 2020
... ). Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion . Int. J. Biochem. Cell Biol.   36 , 1046 - 1069 . 10.1016/j.biocel.2004.01.013 Beri , P. , Popravko , A. , Yeoman , B. , Kumar , A. , Chen , K. , Hodzic , E. , Chiang , A. , Banisadr...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247783.
Published: 22 December 2020
... of the processes by which epithelial tumours regulate their tumour microenvironment, and how new insights into tumour–microenvironment interactions have led to ideas on targeting it as treatments. Microenvironment Cancer Extracellular matrix Mechanobiology Signalling Fibroblasts...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2020) 133 (15): jcs246710.
Published: 5 August 2020
...Marilyn Janice Oentaryo; Anna Chung-Kwan Tse; Chi Wai Lee ABSTRACT Agrin is a crucial factor that induces postsynaptic differentiation at neuromuscular junctions (NMJs), but how secreted agrin is locally deposited in the context of extracellular matrix (ECM) environment and its function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs247312.
Published: 24 July 2020
... of endothelial damage. This introduces a novel control over VWF function. Weibel–Palade bodies von Willebrand Factor Extracellular matrix RGS4 Constitutive secretion Endothelial von Willebrand factor (VWF) plays several roles in haemostasis. This is reflected not only in its central role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs239434.
Published: 15 June 2020
...Joseph H. McCarty ABSTRACT Cells must interpret a complex milieu of extracellular cues to modulate intracellular signaling events linked to proliferation, differentiation, migration and other cellular processes. Integrins are heterodimeric transmembrane proteins that link the extracellular matrix...
Journal Articles
J Cell Sci (2020) 133 (9): jcs239152.
Published: 14 May 2020
...Olivia R. Grafinger; Genya Gorshtein; Tyler Stirling; Megan I. Brasher; Marc G. Coppolino ABSTRACT Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is mediated by matrix...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs241794.
Published: 21 April 2020
...José C. Pastor-Pareja ABSTRACT The evolution of basement membranes (BMs) played an essential role in the organization of animal cells into tissues and diversification of body plans. The archetypal BM is a compact extracellular matrix polymer containing laminin, nidogen, collagen IV and perlecan...
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (7): jcs235762.
Published: 8 April 2020
..., and this correlated with a lack of expression of fibulin-1: an extracellular matrix co-factor for ADAMTS-1 that is known to inhibit migration. These findings support the notion that ADAMTS-1 and syndecan-4 are functionally interconnected in regulating cell migration and angiogenesis, via collaboration with MMP9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs224360.
Published: 9 January 2019
... http://www.biologists.com/user-licence-1-1/ Highlighted Article: Matrix stiffness modulates OSCC cell migration similarly to that of other epithelial carcinomas but by using a different focal-adhesion-mediated mechanism. Cancer Extracellular matrix Elasticity Collagen Hydrogel...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs203950.
Published: 9 April 2018
...Aaron L. Fidler; Sergei P. Boudko; Antonis Rokas; Billy G. Hudson ABSTRACT The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to multicellularity in animals (metazoans), and in the subsequent evolution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs207019.
Published: 6 March 2018
... activity through the GTPase Rab5. Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase The establishment of cell polarity requires vesicular trafficking of proteins to distinct cellular locations, which is crucial for cell migration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3203–3211.
Published: 1 October 2017
... signals that pattern the surrounding tissues. It is composed of a core of vacuolated cells surrounded by an epithelial-like sheath of cells that secrete a thick peri-notochordal basement membrane made of different extracellular matrix (ECM) proteins. The correct deposition and organization of the ECM...