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Keywords: Extracellular matrix
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Journal Articles
J Cell Sci (2024) 137 (6): jcs261666.
Published: 27 March 2024
... of muscle stem cells and their progeny is crucial in strategizing remedies for pathological dysregulation of these cues in aging and disease. In this study, we investigated the cell-level influences of extracellular matrix (ECM) ligands and culture substrate stiffness on primary human myoblast contractility...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells
J Cell Sci (2024) 137 (3): jcs261419.
Published: 12 February 2024
...Samuele Metti; Francesco Da Ros; Giorgia Toniato; Matilde Cescon; Paolo Bonaldo ABSTRACT Adult muscle stem cells (MuSCs) are critical for muscle homeostasis and regeneration, and their behavior relies on a finely regulated niche made of specific extracellular matrix (ECM) components and soluble...
Includes: Supplementary data
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Cell cycle , Polarity
J Cell Sci (2023) 136 (19): jcs261178.
Published: 11 October 2023
...Rebeka Tomasin; Ana Maria Rodrigues; Antonio Carlos Manucci; Alexandre Bruni-Cardoso ABSTRACT Cell context is key for cell state. Using physiologically relevant models of laminin-rich extracellular matrix (lrECM) induction of mammary epithelial cell quiescence and differentiation, we provide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (17): jcs261255.
Published: 4 September 2023
...Petar B. Petrov; James M. Considine; Valerio Izzi; Alexandra Naba ABSTRACT The extracellular matrix (ECM) is a complex meshwork of proteins that forms the scaffold of all tissues in multicellular organisms. It plays crucial roles in all aspects of life – from orchestrating cell migration during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (15): jcs260987.
Published: 31 July 2023
... of Biologists Ltd 2023 Summary: A review of how hemidesmosomes are emerging as playing a crucial role in tissue maintenance, healthy aging and mechanotransduction across different organisms. Hemidesmosome Mechanosignaling YAP1 Healthy aging Extracellular matrix Regeneration...
Journal Articles
J Cell Sci (2022) 135 (24): jcs259978.
Published: 22 December 2022
... of pancreatic tumours is extensive fibrosis and deposition of extracellular matrix (ECM). While pancreatic cancer cells are programmed by stimuli derived from a stiff ECM, metastasis requires loss of attachment and adaptation to a softer microenvironment at distant sites. Growing evidence suggests that stiff...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (23): jcs260232.
Published: 5 December 2022
... plasticity and self-renewal activity. Adhesion of basal cells to laminin α5-containing matrix controls their function by directing them towards a luminal cell fate. Mammary epithelium Progenitor activity Cell identity Adhesion Extracellular matrix Basement membrane Laminin Academy...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (19): jcs260094.
Published: 12 October 2022
...Xuekai Xiong; Weini Li; Jin Nam; Meng Qu; Steve A. Kay; Ke Ma ABSTRACT The circadian clock is entrained to daily environmental cues. Integrin-linked signaling via actin cytoskeleton dynamics transduces physical niche cues from the extracellular matrix to myocardin-related transcription factor (MRTF...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (9): jcs259579.
Published: 6 May 2022
... by either cell–extracellular matrix adhesion or cell–cell adhesion, and both the mechanisms and consequences of inter-tissue adhesion have been studied in vivo in numerous vertebrate and invertebrate species. In this Review, we discuss recent progress in understanding the many functions of inter-tissue...
Journal Articles
Journal Articles
In collection:
Cell migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
.... Introducing leukocytes into the vessels allowed real-time visualization of all different steps of the leukocyte transmigration cascade, including migration into the extracellular matrix. Individual cell tracking over time distinguished striking differences in migratory behaviour between T-cells...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
... the possible synergistic effects of different extracellular matrix components, and might have important roles in cell adhesion and migration in vivo. In particular, since formation of filopodia has been shown to correlate with cancer cell metastasis ( Arjonen et al., 2011 ; Jacquemet et al., 2015 ), our...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (8): jcs256115.
Published: 20 April 2021
...Wenting Bu; Zarina Levitskaya; Suet-Mien Tan; Yong-Gui Gao ABSTRACT Integrin-mediated cell–extracellular matrix (ECM) interactions play crucial roles in a broad range of physiological and pathological processes. Kindlins are important positive regulators of integrin activation. The FERM-domain...
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (24): jcs247189.
Published: 24 December 2020
... Bellail , A. C. , Hunter , S. B. , Brat , D. J. , Tan , C. and Van Meir , E. G. ( 2004 ). Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion . Int. J. Biochem. Cell Biol.   36 , 1046 - 1069 . 10.1016/j.biocel.2004.01.013 Beri , P...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247783.
Published: 22 December 2020
... it as treatments. Microenvironment Cancer Extracellular matrix Mechanobiology Signalling In tissue biology, the terms stroma or microenvironment have been used to distinguish supporting tissue from the parenchyma, a historical term for the functional component of the organ. However, we now know...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2020) 133 (15): jcs246710.
Published: 5 August 2020
...Marilyn Janice Oentaryo; Anna Chung-Kwan Tse; Chi Wai Lee ABSTRACT Agrin is a crucial factor that induces postsynaptic differentiation at neuromuscular junctions (NMJs), but how secreted agrin is locally deposited in the context of extracellular matrix (ECM) environment and its function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs247312.
Published: 24 July 2020
... of endothelial damage. This introduces a novel control over VWF function. Weibel–Palade bodies von Willebrand Factor Extracellular matrix RGS4 Constitutive secretion Endothelial von Willebrand factor (VWF) plays several roles in haemostasis. This is reflected not only in its central role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs239434.
Published: 15 June 2020
...Joseph H. McCarty ABSTRACT Cells must interpret a complex milieu of extracellular cues to modulate intracellular signaling events linked to proliferation, differentiation, migration and other cellular processes. Integrins are heterodimeric transmembrane proteins that link the extracellular matrix...