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Keywords: Exocyst
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Journal Articles
J Cell Sci (2019) 132 (5): jcs223586.
Published: 15 February 2019
... development is distinct from its previously described function in neurons. Exocyst mutants partially phenocopy rab-6.2 -null animals, and rab-6.2- null animals phenocopy mutants that have defective surface glycosylation. These results suggest that RAB-6.2 may mediate the trafficking of one or many secreted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs222430.
Published: 11 February 2019
... and subsequent fusion activity, we analyzed the subcellular localization of several subunits of the exocyst, a tethering complex active during plant cytokinesis. We found that the exocyst complex subunit Sec6 but not the Sec3 or Sec5 subunits localized to microtubule overlap regions in advance of cell plate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3756–3769.
Published: 15 October 2016
... and actin polymerization is fundamental in cell migration, but a dynamic view of the underlying molecular mechanisms is still missing. The Rac1 GTPase controls actin polymerization at protrusions by interacting with its effector, the Wave regulatory complex (WRC). The exocyst complex, which functions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4279–4292.
Published: 1 December 2015
... degeneration, suggestive of differential requirements for exocytosis in the growth and maintenance of different dendritic compartments. Rop promotes dendrite growth together with the exocyst, an octameric protein complex involved in tethering vesicles to the plasma membrane, with Rop–exocyst complexes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 2957–2964.
Published: 15 August 2015
...Bin Wu; Wei Guo ABSTRACT The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2351–2362.
Published: 15 June 2015
...Yohei Katoh; Shohei Nozaki; David Hartanto; Rie Miyano; Kazuhisa Nakayama ABSTRACT In this study, we elucidated the architectures of two multisubunit complexes, the BBSome and exocyst, through a novel application of fluorescent fusion proteins. By processing lysates from cells co-expressing GFP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2483–2492.
Published: 1 June 2014
... ( ebi@mail.med.upenn.edu ) Competing interests The authors declare no competing interests. 2 08 2013 27 03 2014 © 2014. Published by The Company of Biologists Ltd 2014 Cytokinesis Par3 Apical tube formation Exocyst Hepatocyte Polarization Epithelial tissue...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 954–966.
Published: 1 March 2014
... of plasma membrane PtdIns4 P and PtdIns(4,5) P 2 and is crucial for actin organization, membrane trafficking and cell polarity. Female germ cells mutant for PI4KIIIα exhibit defects in cortical integrity associated with failure to recruit the cytoskeletal-membrane crosslinker Moesin and the exocyst subunit...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 686–699.
Published: 1 February 2014
... primary cultures, in vivo postnatal electroporation and conditional genetic ablation, we show that the Ras-like small GTPase RalA and its effector, the exocyst, regulate the morphology and polarized migration of neural progenitors derived from the subventricular zone, a major neurogenic niche...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 4049–4057.
Published: 1 September 2012
... interacts with Rab11, or Exo70, both components of the exocyst tethering complex, leads to essentially the same phenotypes as those of Rab11 depletion. Thus, in addition to its role in recycling processes at perinuclear recycling endosomes, Rab11 is transported along microtubules to the cell periphery...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2885–2895.
Published: 15 June 2012
... of the exocyst complex that is required for efficient exocytosis. Transformation of the Osmo75 mutant with a CreSEC6-GFP construct rescued the mutant completely (osmoregulation and flagellar length). Rescued strains overexpressed CreSEC6 (as a GFP-tagged protein) and displayed a modified CV activity. CVs were...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2725–2732.
Published: 15 August 2010
... by the unspecific nature of interventions. Here we address this problem in relation to atypical PKC (aPKC) action, which in conjunction with the exocyst complex controls the polarised delivery of promigratory signals. A drug-dependent recruitment approach was employed to manipulate the local recruitment of signals...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1499–1506.
Published: 15 May 2009
... RalA in cultured neurons inhibit axon formation. However, expression of a constitutively active RalA mutant that is unable to interact with the exocyst complex has no effect on neuronal polarization. Furthermore, depletion of the Sec6, Sec8 or Exo84 subunits of the exocyst complex also leads...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (17): 2880–2891.
Published: 1 September 2008
... with cytoskeleton dynamics and membrane trafficking probably serve important functions in cellular transformation. One such complex is the Exocyst, which is essential for targeted delivery of membrane and secretory proteins to specific plasma membrane sites to maintain epithelial cell polarity. Upon loss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (5): 807–818.
Published: 1 March 2006
..., including the exocyst components Sec8 and Sec6 and the multidomain scaffolding proteins CASK and Mint1. Sec8 overexpression significantly promotes oligodendrocyte morphological differentiation and myelin-like membrane formation in vitro; conversely, siRNA-mediated interference with Sec8 expression inhibits...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (5): 876–888.
Published: 1 March 2006
... not been fully elucidated. Here, we report that Sec15p, a subunit of the exocyst complex, might provide one line of communication. Not only is Sec15p an effector of the rab protein Sec4p, the master regulator of post-Golgi trafficking, but it also interacts with components of the polarity-establishment...
Journal Articles
J Cell Sci (2002) 115 (13): 2627–2637.
Published: 1 July 2002
... 15 , 663 -673. Brymora, A., Valova, V. A., Larsen, M. R., Roufogalis, B. D. and Robinson, P. J. ( 2001 ). The brain exocyst complex interacts with RalA in a GTP-dependent manner: Identification of a novel mammalian Sec3 gene and a second Sec 15 gene. J. Biol. Chem. 13 , 13 . Burd, C. G...