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Keywords: Epithelial polarity
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Journal Articles
J Cell Sci (2021) 134 (18): jcs255927.
Published: 17 September 2021
... in establishment and maintenance of epithelial polarity; cell division out of plane would lead to a loss of apicobasal polarity. EGFR signaling has been shown to regulate mitotic spindle orientation during symmetric cell division in epithelial cells (via IQGAP1 and NuMA) and asymmetric cell division in stem cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs207779.
Published: 26 March 2018
... pathways regulate adherens junction stability and retention of Bazooka to promote zonula adherens maturation during epithelial cell morphogenesis in Drosophila . Epithelial polarity Pak4 Par3 AFDN Bazooka Photoreceptor Rap1 Zonula adherens The epithelial zonula adherens (ZA) enables...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 219–231.
Published: 1 January 2017
... polarity depends on the Pax8 transcription factor and is linked to the β1-integrin–laminin pathway through Cdh16. Pax8 Cdh16 Epithelial polarity Thyroid follicle The thyroid follicle is the structural and functional unit of the thyroid gland, and comprises a single layer of follicular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4538–4549.
Published: 15 December 2015
...Ya-Huei Lin; Heather Currinn; Shirin Meher Pocha; Alice Rothnie; Thomas Wassmer; Elisabeth Knust ABSTRACT Maintenance of epithelial polarity depends on the correct localization and levels of polarity determinants. The evolutionarily conserved transmembrane protein Crumbs is crucial for the size...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3444–3455.
Published: 15 September 2015
... Highlighted Article: The EGFR ligand betacellulin contains a cytoplasmic basolateral-sorting motif. Mistrafficking of betacellulin, but not other EGFR ligands, induces EGFR-dependent lateral lumens in polarized MDCK cells. Betacellulin EGFR signaling Epithelial polarity Lateral lumens MDCK cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 1011–1022.
Published: 1 March 2015
... ). A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.   Nature   421 , 379 – 384 . 10.1038/nature01296 Miyoshi   H. , Nakau   M. , Ishikawa   T. O. , Seldin   M. F. , Oshima   M. , Taketo   M. M. ( 2002 ). Gastrointestinal hamartomatous...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3568–3577.
Published: 15 August 2014
...Anastasia Mashukova; Zhanna Kozhekbaeva; Radia Forteza; Vipin Dulam; Yolanda Figueroa; Robert Warren; Pedro J. Salas ABSTRACT Atypical PKC (ι/λ and ζ; hereafter referred to as aPKC) is a key player in the acquisition of epithelial polarity and participates in other signaling cascades including...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3585–3592.
Published: 15 August 2013
... Ikenouchi J. and Umeda   M. ( 2010 ). FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.   Proc. Natl. Acad. Sci. USA.   107 , 748 – 753 . 10.1073/pnas.0908423107 Ikenouchi   J. , Suzuki   M. , Umeda   K. , Ikeda   K. , Taguchi   R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3393–3398.
Published: 15 October 2011
...François J.-M. Chartier; Émilie J.-L. Hardy; Patrick Laprise Drosophila Crumbs (Crb) and its mammalian ortholog CRB3 control epithelial polarity through poorly understood molecular mechanisms. Elucidating these mechanisms is crucial, because the physiology of epithelia largely depends...
Journal Articles
J Cell Sci (2011) 124 (19): 3356–3368.
Published: 1 October 2011
... for correspondence ( grazia.pietrini@unimi.it ) 27 5 2011 © 2011. 2011 Cell shape Epithelial polarity F-actin Primary cilia Tight junctions 3D multi-lumen cyst POF1B shRNA Premature ovarian failure (POF) or premature menopause affects 2–3% of women and is characterised by primary...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (16): 2861–2871.
Published: 15 August 2011
... core complex. Immobilization of SJ core components coincided with formation of the morphological SJ but occurred after their known role in maintaining epithelial polarity, suggesting that these functions are independent. In striking contrast to the core components, the tumor suppressor protein Discs...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2491–2503.
Published: 15 July 2009
... Epithelial polarity Protein chaperones Apical kinases The protein kinase C (PKC) family in humans comprises three subclasses: conventional, novel and atypical. They control essential cellular functions ranging from cell proliferation to differentiation, share a highly conserved kinase domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 644–654.
Published: 1 March 2008
... for correspondence (e-mail: psalas@med.miami.edu ) 5 12 2007 © The Company of Biologists Limited 2008 2008 ERM proteins Apical domain Brush border Epithelial polarity The sorting mechanisms responsible for the polarization of membrane proteins in epithelial cells, which result...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3099–3110.
Published: 1 September 2007
...J. Todd Blankenship; Margaret T. Fuller; Jennifer A. Zallen The polarized architecture of epithelial tissues involves a dynamic balance between apical and basolateral membrane domains. Here we show that epithelial polarity in the Drosophila embryo requires the exocyst complex subunit homolog Exo84...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (15): 2594–2608.
Published: 1 August 2007
... for 1 hour at room temperature in TUNEL-POD (Roche) and visualised using a DAB (Sigma) colour reaction. Apoptosis Live imaging Blebbing Epithelial polarity Caspase substrates In Drosophila , DIAP1 constitutes a central point of control during apoptosis. DIAP1 binds...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (18): 4243–4252.
Published: 15 September 2005
... ClC-2 Intestinal epithelium Epithelial polarity MDCK cells LLC-PK1 cells CBS domains Cystic fibrosis (CF) is an autosomal recessive disease that affects the epithelium of the gastrointestinal tract, sweat ducts, respiratory tract and the male reproductive system. The disease is caused...
Journal Articles
J Cell Sci (2005) 118 (17): 4049–4057.
Published: 1 September 2005
... concentration of several components at the border between the apical and lateral domains. * Author for correspondence (e-mail: lebivic@ibdm.univ-mrs.fr ) 7 6 2005 © The Company of Biologists Limited 2005 2005 Epithelial polarity Tight junctions Caco2 Formation of a polarized...
Journal Articles
J Cell Sci (2004) 117 (10): 1899–1909.
Published: 15 April 2004
...., Schober, M. and Perrimon, N. ( 2003 ). Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat. Cell Biol. 5 , 53 -58. Brand, A. H. and Perrimon, N. ( 1993 ). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118...
Journal Articles
J Cell Sci (2002) 115 (23): 4545–4553.
Published: 1 December 2002
... ; Yeaman et al., 1999 ). This polarity is essential for proper epithelial function. Polarized protein transport to the plasma membrane of epithelial cells depends on highly specific vesicular membrane traffic pathways that recognize sorting signals encoded in the cargo proteins. Epithelial polarity...
Journal Articles
J Cell Sci (2002) 115 (6): 1189–1202.
Published: 15 March 2002
.... To address this question, we employed immortalized murine hepatocytes, which display a high degree of differentiation and, expectedly, arrest in the G1 phase under exposure to TGF-β1. These hepatocytes maintain epithelial polarization upon expression of oncogenic Ha-Ras. However, Ras-transformed hepatocytes...