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Keywords: Epithelial–mesenchymal transition
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J Cell Sci (2021) 134 (22): jcs258905.
Published: 23 November 2021
... acts coordinately with basement membrane components to trigger mammary cyst formation. Mammary gland Syntaxin4 Epithelial morphogenesis Epimorphin Basement membrane Epithelialmesenchymal transition Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs243394.
Published: 27 January 2021
..., promoting the epithelialmesenchymal transition (EMT); however, the underlying mechanisms are unknown. We found that silica, matrix stiffening or their combination triggered Ac-α-Tub downregulation in alveolar epithelial cells, followed by DNA damage and replication stress. α-TAT1 elevated Ac-α-Tub to limit...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs237222.
Published: 11 June 2020
...Ganlu Deng; Yihong Chen; Cao Guo; Ling Yin; Ying Han; Yiyi Li; Yaojie Fu; Changjing Cai; Hong Shen; Shan Zeng ABSTRACT Epithelialmesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs217240.
Published: 20 November 2018
... and differentiation of lens epithelial cells that could contribute to vision loss after cataract surgery. Lens TGFβ Epithelial-mesenchymal transition Fibrosis Cataract The lens consists of a monolayer of epithelial cells on its anterior face and the crystallin-rich lens fiber cells, both encased...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5692–5703.
Published: 15 December 2013
... , 11271 – 11278 . 10.1158/0008-5472.CAN-06-2044 Chen   X. , Halberg   R. B. , Burch   R. P. , Dove   W. F. ( 2008 ). Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition.   J. Mol. Histol.   39 , 283 – 294 . 10.1007/s10735-008-9164-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 67–76.
Published: 1 January 2013
...-inflammatory and profibrotic. Cross-talk between TGF-β/Smad and Wnt/β-catenin pathways in epithelialmesenchymal transition (EMT) suggests a specific role for β-catenin in profibrotic effects of TGF-β1. However, no such mechanistic role has been demonstrated for β-catenin in the anti-inflammatory effects...
Journal Articles
J Cell Sci (2010) 123 (20): 3507–3514.
Published: 15 October 2010
... of fibroblast activation protein than did NFs and CAFs. Compared with CAFs and NFs, INFs grown with breast cancer cells were significantly more effective in inducing an epithelial-mesenchymal transition (EMT) in cancer cells, as indicated by induction of vimentin and N-cadherin and downregulation of E-cadherin...
Journal Articles
J Cell Sci (2008) 121 (4): 477–486.
Published: 15 February 2008
...-cadherin, and upregulation of the mRNAs encoding vimentin, α-smooth muscle actin, α(1)(I) collagen and SNAI1/SIP1, together with formation of actin stress fibers and loss of trans-epithelial resistance were found, confirming an epithelial-mesenchymal transition (EMT). The thyroid-specific and epithelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4541–4553.
Published: 1 November 2006
..., radixin, moesin) protein family. Here, we found that human podoplanin directly interacts with ezrin (and moesin) in vitro and in vivo through a cluster of basic amino acids within its cytoplasmic tail, mainly through a juxtamembrane dipeptide RK. Podoplanin induced an epithelial-mesenchymal transition...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (24): 4925–4934.
Published: 15 December 2003
... in cells expressing an E6 protein containing a mutation (Arg153Leu) within a protein kinase A recognition motif that abrogates protein kinase A's negative regulation of the activity of the PDZ-binding domain. The E6-induced changes indicated an epithelial-mesenchymal transition and were supported...
Journal Articles
J Cell Sci (2002) 115 (15): 3193–3206.
Published: 1 August 2002
... Limited 2002 2002 p38MAPK TGFβ Epithelial-mesenchymal transition Cell migration Rac1 The transforming growth factor β (TGFβ) family of secreted factors regulates various biological processes, including cell proliferation,differentiation and apoptosis ( Massague,1998 ). TGFβs signal...