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Keywords: Epigenetic
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Journal Articles
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Imaging
J Cell Sci (2016) 129 (13): 2673–2683.
Published: 1 July 2016
... to the nucleosome, such as the DNA damage-dependent H2A ubiquitylation, which can modify this epigenetic mark at the scale of the genome and result in DNA damage signaling and repair defects. Taken together, these results identify chromatibody as a universal non-invasive tool for either in vivo chromatin imaging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 70–83.
Published: 1 January 2010
.... Although allele-specific epigenetic marks (e.g. DNA methylation and histone modifications) have been extensively studied, our knowledge of higher-order chromatin organization at imprinted gene clusters is still limited. The paternal allele at the mouse Kcnq1 cluster displays a more contracted state than...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (18): 3163–3172.
Published: 15 September 2007
... common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigenetic mechanism can inactivate numerous tumor suppressors and is now recognized as a major contributor to the development of cancer. RASSF1A lacks apparent...
Journal Articles
J Cell Sci (2004) 117 (19): 4355–4363.
Published: 1 September 2004
... heritable patterns of gene expression in response to signals. Epigenetic states can be broadly divided into three categories: euchromatin, constitutive heterochromatin and facultative hetereochromatin. Although the static epigenetic profiles of expressed and silent loci are relatively well characterized...