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Keywords: Endosome
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (17): jcs261448.
Published: 1 September 2023
... distinct transport vesicles at the trans -Golgi network (TGN), and the epsin-related proteins Ent3p and Ent5p (collectively Ent3p/5p) act as accessories for these adaptors. Recently, we showed that vesicle transport from the TGN is crucial for yeast Rab5 (Vps21p)-mediated endosome formation, and that Ent3p...
Includes: Supplementary data
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Membrane trafficking
J Cell Sci (2023) 136 (6): jcs260522.
Published: 8 March 2023
...Shumpei Nakashima; Takahide Matsui; Mitsunori Fukuda ABSTRACT The small GTPase Rab22A is an important regulator of the formation of tubular endosomes, which are one of the types of recycling endosome compartments of the clathrin-independent endocytosis pathway. In order to regulate tubular endosome...
Includes: Supplementary data
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In collection:
Membrane trafficking
J Cell Sci (2023) 136 (6): jcs260566.
Published: 2 March 2023
... and endosomes following internalization, endosomal trafficking of EGFR spatiotemporally regulates EGFR signaling. In this process, leucine-rich repeat kinase 1 (LRRK1) has multiple roles in kinase activity-dependent transport of EGFR-containing endosomes and kinase-independent sorting of EGFR...
Includes: Supplementary data
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In collection:
Membrane trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... homolog, Bph1. We show that Bph1 is an endosomal protein and an effector of the minor Rab5 isoform Ypt52. Strikingly, bph1 Δ mutant cells have lipidated Atg8 on their endosomes, which is sorted via late endosomes into the vacuole lumen under non-autophagy-inducing conditions. In agreement...
Includes: Supplementary data
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Cell migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
... and extracellular matrix adhesion during migration has not been investigated. Here, we reveal a novel role for ALFY in the endocytic pathway and in cell migration. We show that ALFY localizes to RAB5- and EEA1-positive early endosomes in a PtdIns(3)P-dependent manner and is highly enriched in cellular protrusions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (24): jcs259184.
Published: 17 December 2021
... reticulum (ER)-to-Golgi trafficking was severely inhibited. Moreover, we discovered a novel Rab1-depletion phenotype: perinuclear clustering of early endosomes and delayed transferrin recycling. In contrast, acute Rab5 protein depletion resulted in loss of early endosomes and late endosomes, but lysosomes...
Includes: Supplementary data
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In collection:
Membrane trafficking
J Cell Sci (2021) 134 (10): jcs255463.
Published: 27 May 2021
... to lysosomes by kiss and run/membrane fusion entails pore formation commencing at the edge of tether arrays, and demonstrates SNARE redundancy and compensation. Lysosome Endosome Membrane fusion The delivery of endocytosed macromolecules to lysosomal hydrolases in mammalian cells requires kiss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs250670.
Published: 10 February 2021
...Anthony Ravussin; Andreas Brech; Sharon A. Tooze; Harald Stenmark ABSTRACT Late endosomes and lysosomes (endolysosomes) receive proteins and cargo from the secretory, endocytic and autophagic pathways. Although these pathways and the degradative processes of endolysosomes are well characterized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs249136.
Published: 29 December 2020
... through the ER, Ca 2+ is transported towards membrane contact sites with mitochondria or endolysosomes, where it plays key roles in the regulation of essential organellar biology, which are reviewed here. Calcium ER Membrane contact sites Mitochondria Endosome Owing to its distinct...
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In collection:
Membrane trafficking
J Cell Sci (2020) 133 (18): jcs240333.
Published: 16 September 2020
...Mark Remec Pavlin; James H. Hurley ABSTRACT The endosomal sorting complexes required for transport (ESCRTs) I, -II and –III, and their associated factors are a collection of ∼20 proteins in yeast and ∼30 in mammals, responsible for severing membrane necks in processes that range from multivesicular...
Journal Articles
J Cell Sci (2020) 133 (15): jcs246033.
Published: 3 August 2020
...Ashley J. Evans; James L. Daly; Anis N. K. Anuar; Boris Simonetti; Peter J. Cullen ABSTRACT Human retromer, a heterotrimer of VPS26 (VPS26A or VPS26B), VPS35 and VPS29, orchestrates the endosomal retrieval of internalised cargo and promotes their cell surface recycling, a prototypical cargo being...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs247080.
Published: 9 July 2020
...Lena Dehnen; Maren Janz; Jitender Kumar Verma; Olympia Ekaterini Psathaki; Lars Langemeyer; Florian Fröhlich; Jürgen J. Heinisch; Heiko Meyer; Christian Ungermann; Achim Paululat ABSTRACT Endosome biogenesis in eukaryotic cells is critical for nutrient uptake and plasma membrane integrity. Early...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs241455.
Published: 28 April 2020
...Dalton Buysse; Anna-Katharina Pfitzner; Matt West; Aurélien Roux; Greg Odorizzi ABSTRACT The ESCRT-III protein complex executes reverse-topology membrane scission. The scission mechanism is unclear but is linked to remodeling of ESCRT-III complexes at the membrane surface. At endosomes, ESCRT-III...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs231753.
Published: 9 October 2019
... with decreased cellular copper export as a result of disruption of the ATP7B trafficking itinerary and early endosome accumulation when COMMD1 is depleted. PtdIns(4,5)P 2 interaction with COMMD1 as well as COMMD1 abundance could both be important in maintenance of specific membrane protein trafficking pathways...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2019) 132 (19): jcs229179.
Published: 3 October 2019
...Junya Hasegawa; Imen Jebri; Hikaru Yamamoto; Kazuya Tsujita; Emi Tokuda; Hideki Shibata; Masatoshi Maki; Toshiki Itoh ABSTRACT Ubiquitinated membrane proteins such as epidermal growth factor receptor (EGFR) are delivered to early endosomes and then sorted to lysosomes via multivesicular bodies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs189134.
Published: 15 May 2019
... combines current knowledge on their roles in membrane trafficking and diseases. Disease Endosome HOPS Lysosome Membrane trafficking Tethering CHEVI CORVET The endo-lysosomal system consists of a collection of dynamic and interactive compartments that together control cellular...
Includes: Supplementary data
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