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Keywords: Endocytosis
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Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (22): jcs260132.
Published: 21 November 2022
..., the reduction in dynamin-1 is not the single cause of neurodegeneration of these neurons. The reduction in levels of dynamin-1 protein and mRNA, as well as of other endocytosis proteins, in Stxbp1 null mutant neurons suggests that MUNC18-1 directly or indirectly controls expression of other presynaptic genes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (18): jcs260339.
Published: 20 September 2022
...Daniel M. Williams; Lale Gungordu; Anthony Jackson-Crawford; Martin Lowe ABSTRACT Endocytosis allows cells to internalise a wide range of molecules from their environment and to maintain their plasma membrane composition. It is vital during development and for maintenance of tissue homeostasis...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (17): jcs259658.
Published: 7 September 2022
...Vartika Sharma; Bappi Sarkar; Mousumi Mutsuddi; Ashim Mukherjee ABSTRACT Deltex (Dx) is a context-dependent regulator of Notch signaling that can act in a non-canonical fashion by facilitating the endocytosis of the Notch receptor. In an RNAi-based modifier screen of kinases and phosphatases, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259623.
Published: 18 July 2022
... the process of CD166 uptake. We also reveal that the Rho GTPase Rac1, but not Cdc42, is a master regulator of this endocytic route. Finally, we provide evidence that microtubules and kinesin molecular motors are required to potentiate endoA3-dependent endocytosis. Of note, our study also highlights potential...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (10): jcs260059.
Published: 19 May 2022
...- and C-termini of Jen1 in its biogenesis, PM stability and transport activity, using functional analyses of Jen1 truncations and chimeric constructs with UapA, an endocytosis-insensitive transporter of Aspergillus nidulans . Our results show that both N- and C-termini are critical for Jen1 trafficking...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (10): jcs259743.
Published: 17 May 2022
... with ESCRT-III function, the effect of VPS68 deletion on the endocytic cargo protein Ste6 was examined. The ATP-binding cassette (ABC) transporter Ste6 is a very short-lived protein ( Kölling and Hollenberg, 1994 ). After transport to the plasma membrane, it is internalized by endocytosis and moves...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... with this, proteomic analysis of bph1 Δ vacuoles reveals an accumulation of Atg8, reduced flux via selective autophagy, and defective endocytosis. Additionally, bph1 Δ cells have reduced autophagic flux under starvation conditions. Our observations suggest that Bph1 is a novel Rab5 effector that maintains endosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs258733.
Published: 30 December 2021
..., depletion of Snazarus (Snz) led to decreased autophagic flux. Interestingly, we observed altered distribution of Vamp7-positive vesicles with Snz depletion, and the roles of Snz were conserved in human cells. SNX25, the closest human ortholog to Snz, regulates both VAMP8 endocytosis and lipid metabolism...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (19): jcs258587.
Published: 5 October 2021
... of the AP2 adaptor complex, a key player in clathrin-mediated endocytosis, is a highly organized process controlled by alpha- and gamma-adaptin-binding protein (AAGAB, also known as p34). In this study, we demonstrate that besides AP2, AAGAB also regulates the assembly of AP1, a cargo adaptor involved...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (10): jcs258603.
Published: 24 May 2021
...) and ventral compartments ( Fig. 2 B′). Importantly, these Hherisomes shared the same features and characteristics in both compartments. This further indicates that Hherisome formation is downstream of Hh endocytosis. To directly test whether the presence of Hh in Hherisomes depends on Hh endocytosis, we...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (3): jcs217356.
Published: 10 February 2021
.../caveolae-mediated but not clathrin-mediated endocytosis, on its tautomerase activity and, probably, on its thiol protein oxidoreductase activity. As MIF treatment restrained actin polymerisation in vitro , our findings establish a new intracellular role for MIF/D-DT in driving cell motility through...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs249524.
Published: 1 December 2020
...Matthias Corrotte; Mark Cerasoli; Fernando Y. Maeda; Norma W. Andrews ABSTRACT Endocytosis of caveolae has previously been implicated in the repair of plasma membrane wounds. Here, we show that caveolin-1-deficient fibroblasts lacking caveolae upregulate a tubular endocytic pathway and have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs246199.
Published: 12 October 2020
... that endocytosis is required for activation of a subset of Domeless targets. Our data indicate that endocytosis both qualitatively and quantitatively regulates Domeless signalling. STAT92E, the single STAT transcription factor in Drosophila , appears to be the target of endocytic regulation, and our studies show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs247684.
Published: 12 October 2020
...Thomas O. Tolsma; Hallie P. Febvre; Deanna M. Olson; Santiago M. Di Pietro ABSTRACT Endocytosis of plasma membrane proteins is mediated by their interaction with adaptor proteins. Conversely, emerging evidence suggests that adaptor protein recruitment to the plasma membrane may depend on binding...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (17): jcs239681.
Published: 1 September 2020
.../pnas.1309482110 Baschieri , F. , Dayot , S. , Elkhatib , N. , Ly , N. , Capmany , A. , Schauer , K. , Betz , T. , Vignjevic , D. M. , Poincloux , R. and Montagnac , G. ( 2018 ). Frustrated endocytosis controls contractility-independent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs245415.
Published: 21 August 2020
... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Coincidence detection of phosphorylated and ubiquitylated cargo-specific regions is used for epsin target recognition among multiple ubiquitylated proteins in yeast. Endocytosis Internalization Ena1 Epsin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243675.
Published: 14 August 2020
...Fiete Haack; Kai Budde; Adelinde M. Uhrmacher ABSTRACT Endocytosis plays a pivotal regulatory role in canonical WNT signaling. Internalization of the low-density lipoprotein receptor-related protein 6 (LRP6) receptor complex can either promote or attenuate canonical WNT signaling, depending...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244467.
Published: 9 July 2020
... a role for clathrin and/or endocytosis in the regulation of this pathway, but conflicting results exist and demand a deeper mechanistic understanding. We investigated the consequences of clathrin depletion on Wnt/β-catenin signaling in cell lines and found a pronounced reduction in β-catenin protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs242859.
Published: 6 July 2020
... that plays a crucial role in albumin absorption. To date, the mechanism of albumin endocytosis mediated by CUBAM remains to be elucidated. Here, we describe a quantitative assay to evaluate albumin uptake by CUBAM using cells expressing full-length CUBN and elucidate the crucial roles of the C-terminal part...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240861.
Published: 4 June 2020
...Francesco Baschieri; Kseniia Porshneva; Guillaume Montagnac ABSTRACT Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to cluster receptors and to locally bend...