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Keywords: Emerin
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... membrane (INM) protein emerin. Accordingly, we determined the role of emerin in regulating fast amoeboid migration. Strikingly, we found that both the up- and downregulation of emerin results in an inhibition of fast amoeboid migration. However, when key Src phosphorylation sites were removed, upregulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs258969.
Published: 30 March 2022
...Anthony Fernandez; Markville Bautista; Liying Wu; Fabien Pinaud ABSTRACT Emerin is an integral nuclear envelope protein that participates in the maintenance of nuclear shape. When mutated or absent, emerin causes X-linked Emery-Dreifuss muscular dystrophy (EDMD). To understand how emerin takes part...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (9): 1781–1791.
Published: 1 May 2016
... that the EDMD mutation L535P disrupts the nuclear mechanical response specifically in muscle nuclei. Inhibiting lamin prenylation rescued the mechanical response of the EDMD nuclei, reversed the muscle phenotypes and led to normal motility. The LINC complex and emerin were also required to regulate...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (6): 1090–1096.
Published: 15 March 2015
...Adela Morales-Martínez; Agnieszka Dobrzynska; Peter Askjaer ABSTRACT The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and separate functions in regulation of nuclear organization, gene expression and cell differentiation. We report here that emerin (EMR-1) and LEM domain...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (12): 2831–2836.
Published: 15 June 2012
... also causes a nuclear envelope defect. Transport of nucleoporins (Nups) and emerin (EMD) to the nuclear envelope is blocked, resulting in their sequestration in dilated cytoplasmic membranes. Simultaneous overexpression of the FFAT motif (two phenylalanine residues in an acidic track) antagonizes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (10): 1691–1702.
Published: 15 May 2011
...Zinaida Dedeic; Maureen Cetera; Tatiana V. Cohen; James M. Holaska X-linked Emery–Dreifuss muscular dystrophy (X-EDMD) is caused by mutations in the inner nuclear membrane protein emerin. Previous studies have shown that emerin binds to and inhibits the activity of LIM domain only 7 (Lmo7...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (22): 4099–4108.
Published: 15 November 2009
... lamins than in cells from wild-type mice. Knockdown of Sun2 also increased the mobility of a short, chimeric form of nesprin-2 giant (mini-nesprin-2G), whereas the lack of emerin did not affect the mobility of Sun1, Sun2 or mini-nesprin-2G. Fluorescence resonance energy transfer experiments showed Sun1...
Journal Articles
J Cell Sci (2009) 122 (20): 3780–3790.
Published: 15 October 2009
...Kathryn E. Tifft; Katherine A. Bradbury; Katherine L. Wilson X-linked recessive Emery-Dreifuss muscular dystrophy (EDMD) is caused by loss of emerin, a nuclear-membrane protein with roles in nuclear architecture, gene regulation and signaling. Phosphoproteomic studies have identified 13 sites...
Journal Articles
J Cell Sci (2008) 121 (15): 2540–2554.
Published: 1 August 2008
... in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct `core' region of the telophase chromosome and formed an immobile complex by directly binding with other core-localizing NE proteins, such as lamin A and emerin. Correlative light...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (4): 536–548.
Published: 15 February 2008
... termini reside cyto- or nucleoplasmically. Nuclear envelope targeting of LUMA mainly depends on the membrane spans. LUMA's transmembrane domains also promote homooligomerization. LUMA binds A- and B-type lamins and depends on A-type lamins for its INM localization. Furthermore, it interacts with emerin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 1967–1977.
Published: 15 June 2007
... 2007 BAF Nuclear envelope Chromatin Emerin Lamin A Aging Barrier-to-autointegration factor (BAF), a ∼10 kDa dsDNA-binding protein, was first discovered as a host component of retroviral pre-integration complexes that facilitated integrase-mediated integration into target DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4442–4451.
Published: 1 November 2006
... on the nuclear surface of HeLaS3 cells in early cell-cycle stages. Such `pore-free islands' gradually become dispersed in G1-S phase. Surprisingly, the islands are enriched with inner nuclear membrane proteins lamin A/C and emerin, but exclude lamin B. Lamin-A/C-enriched pore-free islands were also observed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2704–2714.
Published: 1 July 2006
... A cDNAs with disease-causing mutations were expressed in HeLa cells. The inner nuclear membrane protein emerin was mislocalised upon expression of the muscular dystrophy mutants G232E, Q294P or R386K, which aberrantly assembled into nuclear aggregates, or upon expression of mutants causing progeria...
Journal Articles
J Cell Sci (2005) 118 (15): 3419–3430.
Published: 1 August 2005
... The Company of Biologists Limited 2005 2005 Emerin Enaptin Lamin A/C NUANCE SUN domain Syne Several lines of evidence suggest the presence of molecular links, which `hard-wire' plasma membrane receptors, cytoskeletal components and nuclear scaffolds together, allowing the physical...
Journal Articles
J Cell Sci (2004) 117 (7): 979–987.
Published: 1 March 2004
... knowledge, we propose lamin-associated complexes with multiple components relevant to nuclear structure (e.g. emerin, nesprin 1α, actin) or signaling and gene regulation (e.g. LAP2α, retinoblastoma, E2F-DP heterodimers, genes) as `food for thought'. Testing these ideas will deepen our understanding...
Journal Articles