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Keywords: EGF receptor
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Journal Articles
J Cell Sci (2017) 130 (15): 2481–2490.
Published: 1 August 2017
...Alejandra Tomas; Sylwia Jones; Simon O. Vaughan; Daniel Hochhauser; Clare E. Futter ABSTRACT EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote nuclear trafficking of endocytosed EGFR...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2015) 128 (5): 935–950.
Published: 1 March 2015
...Qian Wang; Xinmei Chen; Zhixiang Wang ABSTRACT We have shown previously that epidermal growth factor (EGF) receptor (EGFR) endocytosis is controlled by EGFR dimerization. However, it is not clear how the dimerization drives receptor internalization. We propose that EGFR endocytosis is driven...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (3): 722–731.
Published: 1 February 2013
... an Arf6-dependent recycling pathway for β1-integrin and EGF receptors, resulting in inhibition of cell migration and attenuation of signaling downstream of these receptors. Importantly, the phenotypes of decreased cell adhesion and increased cell migration observed following Rab35 knock down...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (9): 1301–1305.
Published: 1 May 2009
... 2009 EGF receptor Total internal reflection fluorescence microscopy Endocytosis The epidermal growth factor receptor (EGFR) is a frequently studied canonical member of the receptor tyrosine kinase superfamily ( Atalay et al., 2003 ). EGFR family members play roles in important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (16): 2635–2642.
Published: 15 August 2008
..., Tiam1 and Vav2 have been shown to transduce the growth signal from the EGF receptor to Rac1. To clarify the role of each GEF, we time-lapse imaged the EGF-induced activity change of Rac1 in A431 cells transfected with siRNA targeting each Rac1 GEF. Because knockdown of these GEFs suppressed EGF-induced...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2005) 118 (14): 3103–3115.
Published: 15 July 2005
... was not essential for Arp2/3-complex-mediated actin assembly at these sites or for EGF receptor-mediated endocytosis, N-WASP deficiency caused a marked reduction of EGF internalization. We conclude that the assembly of WASP subfamily proteins and associated factors at sites of clathrin-coated pit invagination...
Includes: Multimedia, Supplementary data
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Journal Articles
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Journal Articles
J Cell Sci (2001) 114 (17): 3075–3081.
Published: 1 September 2001
... Endocytosis Tyrosine kinase receptor Rab5 Hrs Hgs EGF receptor Cbl The discovery that activated EGF receptor (EGFR) is internalised by endocytosis ( Haigler et al., 1979 ) led to speculation that this pathway provides a means for delivery of the ligand (EGF) to the nucleus, where it could...
Journal Articles
Journal Articles
J Cell Sci (1999) 112 (11): 1733–1741.
Published: 1 June 1999
...Péter Nagy; Attila Jenei; Achim K. Kirsch; János Szöllősi; Sándor Damjanovich; Thomas M. Jovin ABSTRACT ErbB2 (HER2, Neu), a member of the epidermal growth factor (EGF) receptor tyrosine kinase family, is often overexpressed in breast cancer and other malignancies. ErbB2 homodimerizes but also...
Journal Articles
J Cell Sci (1999) 112 (3): 317–327.
Published: 1 February 1999
... 1999 © 1999 by Company of Biologists 1999 EGF receptor Clathrin Adaptor Clathrin coats function at the plasma membrane to promote rapid endocytosis of various receptors and other membrane proteins as well as soluble macromolecules and viruses (reviewed in Schmid, 1997...
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Journal Articles
J Cell Sci (1997) 110 (2): 113–121.
Published: 15 January 1997
... in the presence of mAb 425 05 07 1991 10 09 1991 © 1997 by Company of Biologists 1997 EGF receptor Programmed cell death Keratinocyte Integrin Fig. 1. Morphology of keratinocytes and other normal human cell types pretreated with EGF-R...
Journal Articles