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Keywords: EB1
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Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241216.
Published: 14 May 2020
...Yinlong Song; Yikan Zhang; Ying Pan; Jianfeng He; Yan Wang; Wei Chen; Jing Guo; Haiteng Deng; Yi Xue; Xianyang Fang; Xin Liang ABSTRACT In cells, microtubule dynamics are regulated by plus-end tracking proteins (+TIPs). End-binding protein 1 (EB1, also known as MAPRE1) acts as a master regulator...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4592–4606.
Published: 15 December 2016
...-tracking proteins, the XMAP215, ch-TOG or CKAP5 family and the end-binding 1 (EB1, also known as MAPRE1) family, play pivotal roles in regulating microtubule dynamics. Here, we study the functional interplay between fission yeast Dis1, a member of the XMAP215/TOG family, and Mal3, an EB1 protein. Using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3910–3921.
Published: 1 November 2015
...-related protein Kar9 to the plus ends of astral MTs. Here, we show that Kip2 associates with its processivity factor Bim1, the yeast homologue of the plus-end-tracking protein EB1. This interaction requires an EB1-binding motif in the N-terminal extension of Kip2 and is negatively regulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 4000–4014.
Published: 1 September 2013
... reorganisation during apico-basal epithelial differentiation. Here, we establish for the first time that expression of EB2, but not that of EB1, is crucial for initial microtubule reorganisation during apico-basal epithelial differentiation, and that EB2 downregulation promotes bundle formation. EB2 siRNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3170–3180.
Published: 15 July 2013
... and store refilling restore phosphorylation to basal levels. This phosphorylation occurs in parallel to the dissociation from end-binding protein 1 (EB1), a regulator of growing microtubule ends. Although Ser to Ala mutation of residues 575, 608 and 621 showed a constitutive binding to EB1 even after Ca 2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2539–2551.
Published: 1 August 2011
...Jacob M. Schrøder; Jesper Larsen; Yulia Komarova; Anna Akhmanova; Rikke I. Thorsteinsson; Ilya Grigoriev; Robert Manguso; Søren T. Christensen; Stine F. Pedersen; Stefan Geimer; Lotte B. Pedersen The microtubule (MT) plus-end-tracking protein EB1 is required for assembly of primary cilia in mouse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (9): 1460–1467.
Published: 1 May 2010
... the effect of Rab8, Rab5 and Rab23 on the ciliary transport of the HH-associated transmembrane receptor Smoothened, the microtubular tip protein EB1, and the receptor protein Kim1. Ciliary FRAP confirmed the role of Rab8 in protein entry to the cilium. Dominant negative Rab5 had no impact on the ciliary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 451–459.
Published: 1 February 2010
...Shinichiro Komaki; Tatsuya Abe; Silvie Coutuer; Dirk Inzé; Eugenia Russinova; Takashi Hashimoto End-binding 1 (EB1) proteins are evolutionarily conserved plus-end-tracking proteins that localize to growing microtubule plus ends where they regulate microtubule dynamics and interactions...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3531–3541.
Published: 1 October 2009
... on microtubule growth velocity. In addition, HDAC6 was found to be physically associated with the microtubule end-tracking protein EB1 and a dynactin core component, Arp1, both of which accumulate at the tips of growing microtubules. We hypothesize that inhibition of HDAC6 catalytic activity may affect...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2969–2979.
Published: 15 August 2009
... the region responsible for the IQGAP1 binding. Phosphorylation of CLASP2 results in the dissociation of CLASP2 from IQGAP1, EB1 and microtubules. At the leading edges of migrating fibroblasts, CLASP2 near microtubule ends partially colocalises with IQGAP1. Expression of active GSK-3β abrogates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1401–1409.
Published: 1 May 2009
... cells. We do not yet understand these events, but they present similarities with the polarized migration of fibroblasts, in which EB1 is necessary for microtubule stabilization. However, it was recently reported that EB3, not EB1, is involved in muscle cell elongation and fusion, and that neither...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (24): 4416–4425.
Published: 15 December 2007
... plus ends ( Fig. 9B ). The maximum fluorescence peaks of EB1 and CLASP were clearly separated with an average distance of 0.6±0.16 μm (number of measured MT ends, n =10). The presence of CLASP proteins in diverse phylogenetic groups, including both unicellular and multicellular organisms...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3327–3335.
Published: 1 October 2007
... domains, through which it binds to various proteins, including β-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies using mutant mice and cultured cells have demonstrated that APC suppresses canonical Wnt signalling, which is essential for tumorigenesis, development and homeostasis...
Journal Articles
J Cell Sci (2007) 120 (17): 3111–3122.
Published: 1 September 2007
... that regulates this process. Using yeast two-hybrid screening, we identified MT plus-end binding protein (EB1) as a melanocyte-expressed Mlph-interacting protein. To address the role of EB1 versus Rab27a and MyoVa interactions in Mlph targeting and function, we used siRNA and Mlph mutations to specifically...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (15): 3193–3205.
Published: 1 August 2006
...Pankaj Dhonukshe; Norbert Vischer; Theodorus W. J. Gadella, Jr The spindle occupies a central position in cell division as it builds up the chromosome-separating machine. Here we analysed the dynamics of spindle formation in acentrosomal plant cells by visualizing microtubules labelled with GFP-EB1...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2780–2786.
Published: 1 July 2006
... that this response is polarized to the site where the cell membrane had previously been disrupted. Observations of GFP-tagged α-tubulin and end-binding protein 1 (EB1) revealed that membrane disruption initially induced disassembly of microtubules around the wound site, followed by elongation of microtubules toward...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2758–2767.
Published: 1 July 2006
...Peter Watson; David J. Stephens Microtubule dynamics and function are regulated, at least in part, by a family of proteins that localize to microtubule plus-ends, and include EB1, CLIP-170 and the dynactin component p150 Glued . Plus-end pools of these proteins, notably dynactin, have been invoked...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (16): 3781–3790.
Published: 15 August 2005
... association to microtubule plus-ends is regulated during the cell cycle. Microtubule plus-end association is strong in interphase and greatly attenuated during mitosis. Another microtubule plus-end tracking protein, EB1, directly interacts with the CAP-Gly domain of CLIP-190 and is required to localise CLIP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (7): 1117–1128.
Published: 1 March 2004
...Ryan K. Louie; Shirin Bahmanyar; Kathleen A. Siemers; Violet Votin; Paul Chang; Tim Stearns; W. James Nelson; Angela I. M. Barth Adenomatous polyposis coli (APC) and End-binding protein 1 (EB1) localize to centrosomes independently of cytoplasmic microtubules (MTs) and purify with centrosomes from...
Includes: Multimedia, Supplementary data