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Keywords: Drosophila
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Journal Articles
In collection:
Lipid Biology
J Cell Sci (2023) 136 (22): jcs261563.
Published: 23 November 2023
... affect neuronal development and function. We generated transgenic flies that express the cholesterol-binding D4H domain of perfringolysin O toxin and found increased levels of cholesterol in presynaptic terminals of Drosophila larval neuromuscular junctions following increased synaptic activity. Reduced...
Journal Articles
In collection:
Adhesion
J Cell Sci (2023) 136 (20): jcs260974.
Published: 16 October 2023
.... Inhibition of fusion does not improve the lifespan of the fly, but does enhance its biomechanical fitness, a measure of the healthspan of the animal. Remarkably, Drosophila can maintain their epithelial tension and abdominal movements with age when cell fusion is inhibited. Epithelial cell fusion also...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Polarity
J Cell Sci (2023) 136 (19): jcs261118.
Published: 5 October 2023
.... In invertebrates, these functions depend on formation and maintenance of ‘tight’ septate junctions (SJs). However, the mechanism by which SJs affect transport competence and tissue homeostasis, and how these are modulated by ageing, remain incompletely understood. Here, we demonstrate that the Drosophila renal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (5): jcs261173.
Published: 11 September 2023
... protrusion and retraction to opposite sides of the interface. However, how signaling proteins become organized at interfaces to accomplish this is poorly understood. The follicular epithelial cells of Drosophila melanogaster have two signaling modules at their leading-trailing interfaces — one composed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (13): jcs259935.
Published: 11 July 2023
...-muscle Myosin II along the interface between differently fated groups of cells contributes to boundary integrity and maintains its shape via increased tension. Here, using the Drosophila wing imaginal disc, we tested whether interfacial tension driven by accumulation of Myosin is responsible...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (13): jcs261026.
Published: 4 July 2023
... exocytosis that commonly mediates peptide hormone release by endocrine cells, DCVs at the Drosophila neuromuscular junction release their contents via fusion pores formed by kiss-and-run exocytosis. Here, we used fluorogen-activating protein (FAP) imaging to reveal the permeability range of synaptic DCV...
Journal Articles
Journal Articles
J Cell Sci (2023) 136 (7): jcs260525.
Published: 11 April 2023
...) are key components of such regulatory feedback networks. In Drosophila , HSPGs serve as co-receptors for a number of morphogens, including Hedgehog (Hh), Wingless (Wg), Decapentaplegic (Dpp) and Unpaired (Upd, or Upd1). Recently, Windpipe (Wdp), a chondroitin sulfate (CS) proteoglycan (CSPG), was found...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2023) 136 (6): jcs260366.
Published: 5 March 2023
.... Here, we identified the conserved actin-crosslinking protein Swip-1 as a novel regulator controlling exocytosis of glue granules in the Drosophila salivary gland. Real-time imaging revealed that Swip-1 is simultaneously recruited with F-actin onto secreting granules in proximity to the apical membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (5): jcs260447.
Published: 24 February 2023
... along compartment boundaries remain elusive. Here, we show that non-muscle Myosin II and F-actin transiently accumulate and mechanical tension is increased at cell junctions along the forming anteroposterior compartment boundary in the Drosophila melanogaster pupal abdominal epidermis. Fluorescence...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (20): jcs250134.
Published: 20 October 2022
... that is under-investigated, however, is that phagocytes not only engulf corpses but contribute to cell death progression. The aims of this study were to determine how the phagocytic receptor Draper non-autonomously induces cell death, using the Drosophila ovary as a model system. We found that Draper, expressed...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (17): jcs259658.
Published: 7 September 2022
... identified Thickveins (Tkv), the receptor of Decapentaplegic (Dpp), as one of the interactors of Dx. Dpp, a Drosophila homolog of TGF-β and bone morphogenetic proteins, acts as a morphogen to specify cell fate along the anterior–posterior axis of the wing. Tight regulation of Dpp signaling is thus...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (14): jcs260249.
Published: 19 July 2022
... comprise heterogeneous populations of stem and differentiated cells. Here, we examine Ca 2+ dynamics in the adult Drosophila intestine, a self-renewing epithelial organ in which stem cells continuously produce daughters that differentiate into either enteroendocrine cells or enterocytes. Live imaging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (11): jcs259547.
Published: 31 May 2022
... controversial. Here, we use genome editing to delete the PDZ domain-encoding region from Drosophila dishevelled . Canonical Wingless signalling is entirely normal in these deletion mutants; however, they show defects in multiple contexts controlled by noncanonical Wnt signalling, such as planar polarity. We use...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (7): jcs259092.
Published: 14 April 2022
... cells are induced to liberate fatty acids from lipid droplets. We have shown a non-canonical role for a subset of peroxisome-assembly [Peroxin (Pex)] proteins in this process in Drosophila . Transmembrane proteins Pex3, Pex13 and Pex14 were observed to surround newly formed lipid droplets. Trafficking...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (3): jcs259590.
Published: 3 February 2022
... extensively in cultured cells, studies of EVs in vivo have remained scarce. We report here that EVs are present in the developing lumen of tracheal tubes in Drosophila embryos. We define two distinct EV subpopulations, one of which contains the Munc13-4 (also known as UNC13D) homolog Staccato (Stac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259132.
Published: 24 January 2022
...Eliana F. Torres-Zelada; Smitha George; Hannah R. Blum; Vikki M. Weake ABSTRACT The histone acetyltransferase Gcn5 is critical for gene expression and development. In Drosophila , Gcn5 is part of four complexes (SAGA, ATAC, CHAT and ADA) that are essential for fly viability and have key roles...
Includes: Supplementary data
Journal Articles