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Keywords: Drosophila
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (23): jcs260110.
Published: 7 December 2022
... of ribosomal subunits. Here, we show that Drosophila NOC1 (annotated CG7839) is necessary for rRNAs maturation and for a correct animal development. Its ubiquitous downregulation results in a dramatic decrease in polysome level and of protein synthesis. NOC1 expression in multiple organs...
Includes: Supplementary data
Journal Articles
J Cell Sci jcs.260196.
Published: 29 November 2022
...Hitomi Yamashita; Yuka Ochi; Yumi Yamada; Shogo Sasaki; Tatsuya Tago; Takunori Satoh; Akiko K. Satoh Polarized transport is essential for constructing multiple plasma membrane domains in the cell. Drosophila photoreceptors are an excellent model system to study the mechanisms of polarized transport...
Journal Articles
J Cell Sci (2022) 135 (20): jcs250134.
Published: 20 October 2022
... that is under-investigated, however, is that phagocytes not only engulf corpses but contribute to cell death progression. The aims of this study were to determine how the phagocytic receptor Draper non-autonomously induces cell death, using the Drosophila ovary as a model system. We found that Draper, expressed...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (17): jcs259658.
Published: 7 September 2022
... identified Thickveins (Tkv), the receptor of Decapentaplegic (Dpp), as one of the interactors of Dx. Dpp, a Drosophila homolog of TGF-β and bone morphogenetic proteins, acts as a morphogen to specify cell fate along the anterior–posterior axis of the wing. Tight regulation of Dpp signaling is thus...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (14): jcs260249.
Published: 19 July 2022
... comprise heterogeneous populations of stem and differentiated cells. Here, we examine Ca 2+ dynamics in the adult Drosophila intestine, a self-renewing epithelial organ in which stem cells continuously produce daughters that differentiate into either enteroendocrine cells or enterocytes. Live imaging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (11): jcs259547.
Published: 31 May 2022
... controversial. Here, we use genome editing to delete the PDZ domain-encoding region from Drosophila dishevelled . Canonical Wingless signalling is entirely normal in these deletion mutants; however, they show defects in multiple contexts controlled by noncanonical Wnt signalling, such as planar polarity. We use...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (7): jcs259092.
Published: 14 April 2022
... cells are induced to liberate fatty acids from lipid droplets. We have shown a non-canonical role for a subset of peroxisome-assembly [Peroxin (Pex)] proteins in this process in Drosophila . Transmembrane proteins Pex3, Pex13 and Pex14 were observed to surround newly formed lipid droplets. Trafficking...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (3): jcs259590.
Published: 3 February 2022
... extensively in cultured cells, studies of EVs in vivo have remained scarce. We report here that EVs are present in the developing lumen of tracheal tubes in Drosophila embryos. We define two distinct EV subpopulations, one of which contains the Munc13-4 (also known as UNC13D) homolog Staccato (Stac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259132.
Published: 24 January 2022
...Eliana F. Torres-Zelada; Smitha George; Hannah R. Blum; Vikki M. Weake ABSTRACT The histone acetyltransferase Gcn5 is critical for gene expression and development. In Drosophila , Gcn5 is part of four complexes (SAGA, ATAC, CHAT and ADA) that are essential for fly viability and have key roles...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (24): jcs259570.
Published: 16 December 2021
... (PAINT) routinely gives 30 nm resolution or better at depths greater than 20 µm. This revealed that the nuclear pores are nonrandomly distributed in most Drosophila tissues, in contrast to what is seen in cultured cells. Lamin Dm 0 shows a complementary localization to the nuclear pores, suggesting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (21): jcs258973.
Published: 5 November 2021
... function for the distribution of F-actin plus and minus ends. In syncytial Drosophila embryos, Rho1 signaling is high between actin caps, i.e. the cortical intercap region. Capping protein binds to free plus ends of F-actin to prevent elongation of the filament. Capping protein has served as a marker...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (20): jcs258512.
Published: 22 October 2021
... in neurons. In the present study, we demonstrate that the Drosophila ankyrin repeat and KH domain-containing protein Mask negatively affects MT stability in both larval muscles and motor neurons. In larval muscles, loss-of-function of mask increases MT polymer length, and in motor neurons, loss of mask...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (5): jcs259086.
Published: 20 August 2021
... membrane contact sites to be described; however, the protein composition and molecular function of these sites is still emerging. Here, we leverage yeast and Drosophila model systems to uncover a novel role for the Hobbit (Hob) proteins at ER–PM contact sites. We find that Hobbit localizes to ER–PM contact...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (15): jcs259037.
Published: 3 August 2021
...); after budding from the TGN, granules undergo modifications, including an increase in size. These changes occur during a poorly understood process called secretory granule maturation. Here, we leverage the Drosophila larval salivary glands as a model to characterize a novel role for Rab GTPases during...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs254037.
Published: 23 July 2021
...Janet K. Jang; Amy C. Gladstein; Arunika Das; Joanatta G. Shapiro; Zachary L. Sisco; Kim S. McKim ABSTRACT Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on the chromosomal passenger complex (CPC...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2021) 134 (14): jcs258757.
Published: 22 July 2021
..., this process must be tightly controlled. Here, we show that a translational regulator, me31B , plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B , spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (10): jcs258603.
Published: 24 May 2021
...Sandrine Pizette; Tamás Matusek; Bram Herpers; Pascal P. Thérond; Catherine Rabouille ABSTRACT In metazoans, tissue growth and patterning is partly controlled by the Hedgehog (Hh) morphogen. Using immuno-electron microscopy on Drosophila wing imaginal discs, we identified a cellular structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs257592.
Published: 11 May 2021
... regulated by secreted glycan-binding lectins. Using the Drosophila neuromuscular junction (NMJ) as a model glutamatergic synapse, we identify a new Ca 2+ -binding (C-type) lectin, Lectin-galC1 (LGC1), which modulates presynaptic function and neurotransmission strength. We find that LGC1 is enriched...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (9): jcs258269.
Published: 7 May 2021
... and regulation patterns of SLK in development and disease, that make it a potential therapeutic target. Drosophila SLK STK2 Ste20 kinase Animal models Signaling Fig. 1. SLK structure and homologies. Schematic representation of the murine SLK structure showing the Ste20 kinase domain...