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Keywords: Diabetes
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259187.
Published: 10 January 2022
...Kayla F. Titialii-Torres; Ann C. Morris ABSTRACT Diabetes is linked to various long-term complications in adults, such as neuropathy, nephropathy and diabetic retinopathy. Diabetes poses additional risks for pregnant women, because glucose passes across the placenta, and excess maternal glucose can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs249060.
Published: 7 May 2021
..., hypertension and diabetes. Actin Atherosclerosis Diabetes Hypertension Profilin Profilins (Pfns) belong to a class of small 14 to 17 kDa proteins that bind to actin monomers, also referred to as G-actin, that are found in essentially every eukaryotic organism and some viruses ( Krishnan...
Journal Articles
J Cell Sci (2020) 133 (19): jcs235838.
Published: 12 October 2020
... investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive expression of insulin-degrading enzyme led to insufficient insulin levels in diabetic skin during wound healing, which ultimately reduced the recovery rate of diabetic wounds. We confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (14): jcs215939.
Published: 26 July 2018
...Samuel M. Bestall; Richard P. Hulse; Zoe Blackley; Matthew Swift; Nikita Ved; Kenneth Paton; Nicholas Beazley-Long; David O. Bates; Lucy F. Donaldson ABSTRACT Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 541–550.
Published: 1 February 2017
... exocytosis. Small GTPase Secretory granule Regulated exocytosis Insulin Pancreatic β-cell Diabetes Regulated secretion is a main pathway in the delivery of the bioactive molecules of a cell to the extracellular environment. The pathway comprises coordinated sequential steps...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 143–151.
Published: 1 January 2017
... . Bonner-Weir , S. ( 1988 ). Morphological evidence for pancreatic polarity of beta cell within islets of Langerhans . Diabetes   37 , 616 - 621 . 10.2337/diab.37.5.616 Bryant , D. M. , Datta , A. , Rodriguez-Fraticelli , A. E. , Peränen , J. , Martín-Belmonte , F...
Includes: Supplementary data
Journal Articles
In collection:
Imaging , Metabolism
J Cell Sci (2016) 129 (14): 2865–2875.
Published: 15 July 2016
...Ge Li; Binlin Wu; Meliza G. Ward; Angie C. N. Chong; Sushmita Mukherjee; Shuibing Chen; Mingming Hao ABSTRACT Pancreatic islet dysfunction leading to insufficient glucose-stimulated insulin secretion triggers the clinical onset of diabetes. How islet dysfunction develops is not well understood...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2462–2471.
Published: 15 June 2016
...Yi Wang; Chengsheng Han; Wenzhen Zhu; Zhengxing Wu; Yanmei Liu; Liangyi Chen ABSTRACT Imbalanced glucagon and insulin release leads to the onset of type 2 diabetes. To pinpoint the underlying primary driving force, here we have developed a fast, non-biased optical method to measure ratios...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 637–649.
Published: 1 February 2016
... PI3K and induces endocytosis through promoting signaling crosstalk between Arf6 and Rab27a pathways. Endocytosis Small GTPase Insulin Membrane trafficking Diabetes Pancreatic β-cells Bidirectional intracellular trafficking is fundamental to maintain cellular homeostasis. In secretory...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2009) 122 (12): 1970–1978.
Published: 15 June 2009
... a role in NE dynamics. * Author for correspondence (e-mail: ornacf@helix.nih.gov ) 9 3 2009 © The Company of Biologists Limited 2009 2009 Peripheral ER Lamin Nuclear shape Nuclear architecture Lipid droplets Diabetes Insulin resistance Majeed syndrome In metazoa...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (23): 4071–4079.
Published: 1 December 2007
... by lipid dephosphorylation at the plasma membrane, PTEN also resides in the cytoplasm and nucleus, and its subcellular distribution is under strict control. Deregulation of PTEN function is implicated in other human diseases in addition to cancer, including diabetes and autism. e-mails: tmeyer...
Journal Articles
J Cell Sci (2007) 120 (2): 239–245.
Published: 15 January 2007
... outside the mammalian pancreas has implications for regenerative medicine, indicating that biliary epithelium might offer a new source of β cells for the treatment of diabetes. The finding also has evolutionary significance, because it is known that certain basal vertebrates usually form all of their β...