...-licence-1-1/ Polycystin Pkd2 Schizosaccharomyces Fission yeast Cytokinesis Transmembrane Eisosome ER-PM contact National Institutes of Health R15GM134496 National Science Foundation 2144701 © 2023. Published by The Company of Biologists Ltd. Cytoplasmic tail...

...Udo N. Onwubiko; Dhanya Kalathil; Emma Koory; Sahara Pokharel; Hayden Roberts; Ahmad Mitoubsi; Maitreyi Das ABSTRACT During cytokinesis, a series of coordinated events partition a dividing cell. Accurate regulation of cytokinesis is essential for proliferation and genome integrity. In fission yeast...

... cell surface and translocate to the cleavage furrow during cytokinesis. The localization of PCDH7 depends on the palmitoylation activity of ZDHHC5. Silencing PCDH7 increases the percentage of multinucleated cells and the duration of mitosis. Loss of PCDH7 expression correlates with reduced levels...

... polyploidization in a mammalian ancestor. Cytokinesis Evolution Megakaryocytes Platelets Polyploidy University of Cambridge http://dx.doi.org/10.13039/501100000735 Evolution through natural selection as described by Darwin is the bedrock of biodiversity ( Darwin, 1859 ). Among...

... filaments, required for cytokinesis by many organisms. In fission yeast cofilin mutants, contractile rings suffer bridging instabilities in which segments of the ring peel away from the plasma membrane, forming straight bridges whose ends remain attached to the membrane. The origin of bridging instability...

... induced misplacement of basal bodies, a defect in the furrow or fold generation, and eventually cell death. We hypothesize that TFK1 is a basal body positioning-specific actor and a key regulator of cytokinesis in the bloodstream form Trypanosoma brucei . Trypanosome BBs act as vital master...

...Günther Gerisch; Jana Prassler; Mary Ecke ABSTRACT In multi-nucleate cells of Dictyostelium , cytokinesis is performed by unilateral cleavage furrows that ingress the large cells from their border. We use a septase (sepA)-null mutant with delayed cytokinesis to show that in anaphase a pattern...

... membrane-localized fission yeast polycystin homolog Pkd2p is an essential protein required for cytokinesis; however, its role remains unclear. Here, we isolated a novel temperature-sensitive pkd2 mutant, pkd2-B42 . Among the strong growth defects of this mutant, the most striking was that many mutant cells...

...Imge Ozugergin; Karina Mastronardi; Chris Law; Alisa Piekny ABSTRACT Cytokinesis occurs at the end of mitosis as a result of the ingression of a contractile ring that cleaves the daughter cells. The core machinery regulating this crucial process is conserved among metazoans. Multiple pathways...

...Julie Rich-Robinson; Afton Russell; Eleanor Mancini; Maitreyi Das ABSTRACT In fission yeast, polarized cell growth stops during division and resumes after cytokinesis completes and cells separate. It is unclear how growth reactivation is timed to occur immediately after cell separation. We...

...Alaina H. Willet; Maya G. Igarashi; Jun-Song Chen; Rahul Bhattacharjee; Liping Ren; Sierra N. Cullati; Zachary C. Elmore; Rachel H. Roberts-Galbraith; Alyssa E. Johnson; Janel R. Beckley; Kathleen L. Gould ABSTRACT The F-BAR protein Imp2 is an important contributor to cytokinesis in the fission...

...Nicholas V. G. Iannantuono; Gregory Emery ABSTRACT Cytokinesis occurs at the end of mitosis/meiosis wherein the cytoplasms of daughter cells are separated. Before abscission, an intercellular bridge containing the remaining furrowing machinery, mitotic spindle and actin cytoskeleton connects...

... and is required for cytokinesis. The association between KIF1BP and CITK can be influenced by CITK activity, and the two proteins may antagonize each other for their midbody localization. KIF1BP knockdown decreases microtubule stability, increases KIF23 midbody levels and impairs midbody localization of KIF14...

...: A discussion of the roles of the spindle midzone, a microtubule-containing structure that connects the two half-spindles during mitosis, contributes to chromosome segregation and specifies the location of cytokinetic furrowing. Midzone Cytokinesis Anaphase Spindle elongation Microtubule...

...Mathieu C. Husser; Noha Skaik; Vincent J. J. Martin; Alisa Piekny ABSTRACT Cytokinesis is the process that separates a cell into two daughter cells at the end of mitosis. Most of our knowledge of cytokinesis comes from overexpression studies, which affects our interpretation of protein function...

...Patrick Partscht; Borhan Uddin; Elmar Schiebel ABSTRACT The budding yeast phosphatase Cdc14 has a central role in mitotic exit and cytokinesis. Puzzlingly, a uniform picture for the three human CDC14 paralogues CDC14A, CDC14B and CDC14C in cell cycle control has not emerged to date. Redundant...

...Stefano Sechi; Anna Frappaolo; Angela Karimpour-Ghahnavieh; Roberta Fraschini; Maria Grazia Giansanti ABSTRACT In animal cell cytokinesis, interaction of non-muscle myosin II (NMII) with F-actin provides the dominant force for pinching the mother cell into two daughters. Here we demonstrate...

...Destiny J. Davis; Minmin Wang; Iben Sørensen; Jocelyn K. C. Rose; David S. Domozych; Georgia Drakakaki ABSTRACT Cytokinesis in land plants involves the formation of a cell plate that develops into the new cell wall. Callose, a β-1,3 glucan, accumulates at later stages of cell plate development...

... microtubule bundles bridging daughter cells are severed. Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated...

.... , Plumer , T. M. and Xiao , J. ( 2016 ). Defining the rate-limiting processes of bacterial cytokinesis . Proc. Natl. Acad. Sci. USA   113 , E1044 - E1053 . 10.1073/pnas.1514296113 Daley , D. O. , Skoglund , U. and Söderström , B. ( 2016 ). FtsZ does not initiate membrane...