... in kidney failure. Integrin α3α6-null collecting duct epithelial cells showed increased secretion of pro-inflammatory cytokines and displayed mesenchymal characteristics, causing loss of barrier function. These features resulted from increased nuclear factor kappa-B (NF-κB) activity, which regulated...

... by The Company of Biologists Ltd 2013 Adult neurogenesis Cytokines Neural stem cell Neuronal differentiation The subventricular zone (SVZ) of the lateral ventricle (LV) is the main neurogenic area in the adult murine brain. The neural stem cells (NSCs, Type B cells) present in the SVZ...

... growth factors and cytokines, such as IL6 and IL8, which collectively constitute the senescence-associated secretory phenotype (SASP). The SASP can signal to the tumor environment and elicit the immune-mediated clearance of tumor cells or, depending on the context, could potentially promote tumor...

... Apoptosis Cell growth Cytokines Cytokines belonging to the interferon (IFN) group potently suppress cell growth and promote apoptosis ( Kimchi, 1992 ). They exert antiviral, immuno-regulatory and anti-proliferative effects employing the JAK (Janus tyrosine kinase)-STAT (signal transducer...

... consists of two cytokine receptor homology (CRH) domains separated by an immunoglobulin-like domain, and followed by two juxtamembrane fibronectin type III modules. The CRH2 domain functions as a high-affinity binding site for leptin, and we previously demonstrated interaction with helices A and C...

... subunit of the CNTF receptor complex has a distinct distribution in polarised cells which may reflect the different roles the respective cytokines play in vivo. Since it is currently believed that lipid rafts are involved in signal transduction as well as protein sorting we studied the association...

... protein values were measured in the culture supernatants for IL-1β (data not shown). As expected, and due to the lack of both inducer cytokines, RNA expression (data not shown) and protein secretion of KGF and GM-CSF by co-cultured fibroblasts were strongly reduced throughout the first week in culture...