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Keywords: Cyclin E
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (4): 981–992.
Published: 15 February 2012
..., the mechanisms underlying Plk2-induced centriole duplication are incompletely understood. Here, we show that Plk2 directly targets the F-box protein F-box/WD repeat-containing protein 7 (Fbxw7), which is a regulator of the ubiquitin-mediated degradation of cyclin E. Plk2 phosphorylates Fbxw7 on serine 176...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3224–3232.
Published: 1 October 2008
.... Cyclin E–Cdk2 has been implicated in regulating centrosome duplication both in Xenopus embryos and extracts and in mammalian cells. Localization of cyclin E on centrosomes is mediated by a 20-amino acid domain termed the centrosomal localization sequence (CLS). In this paper, cyclin E is shown...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1994) 107 (2): 581–588.
Published: 1 February 1994
...Andreas Sewing; Volker Rönicke; Christiane Bürger; Martin Funk; Rolf Müller ABSTRACT Cyclin E is a regulatory subunit of the cdc2-related protein kinase cdk2, which is activated shortly before S-phase entry, thus defining it as a G 1 cyclin. We report here the existence of a 43 kDa splice variant...
Journal Articles
J Cell Sci (1993) 105 (1): 123–133.
Published: 1 May 1993
... to the absence, in senescent cells, of a regulatory loop that would normally control their expression. This is sup-ported by our finding that cyclin E-associated kinase activity in senescent cells is reduced approx. 14-fold. Our data also suggest that the deregulated expression of cyclin D1 and E...