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Keywords: Cul3
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Journal Articles
J Cell Sci (2019) 132 (21): jcs233049.
Published: 6 November 2019
... of the cyclin E N-terminus occurs in some cancers and is associated with increased cyclin E–Cdk2 activity and poor clinical prognosis. Cyclin E levels are tightly regulated and controlled in part through ubiquitin-mediated degradation initiated by one of two E3 ligases, Cul1 and Cul3. Cul1 ubiquitylates...
Includes: Supplementary data