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Keywords: Crk
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Journal Articles
J Cell Sci (2008) 121 (18): 3071–3082.
Published: 15 September 2008
...-display library. A combination of protein overexpression, silencing, pharmacological manipulation and mutational analysis demonstrated that the PxxP motifs of Abl exert their effects on actin organization by two distinct mechanisms, involving the inhibition of Crk signaling and the engagement of Nck...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1869–1875.
Published: 1 June 2008
... neurons enhances dendritogenesis by approximately twofold and in a manner dependent on Src family kinases. This enhancement is blocked by reducing expression of Crk family proteins, adaptor molecules that interact with Dab1 in a tyrosine phosphorylation-dependent manner. Retrovirally expressed inhibitory...
Journal Articles
J Cell Sci (2006) 119 (5): 923–932.
Published: 1 March 2006
... with the signalling adaptor protein Crk. Recently, the complex formation between Dock180 and Elmo1 was reported to function as a bipartite guanine nucleotide exchange factor for Rac. In this study, we demonstrated that the amount of Dock180 increased when Elmo1 was co-expressed. Dock180 was found to be ubiquitylated...
Journal Articles
J Cell Sci (2005) 118 (20): 4849–4863.
Published: 15 October 2005
... overexpression stimulated motility. Together our data support a role for paxillin δ as a naturally occurring functional antagonist of paxillin signaling potentially through suppression of a Crk-mediated pathway during processes associated with cell migration. Herein, we provide evidence for the existence...
Journal Articles
J Cell Sci (2005) 118 (19): 4353–4364.
Published: 1 October 2005
... 2005 © The Company of Biologists Limited 2005 2005 CRK Cell cycle Cytoskeleton The African trypanosome, Trypanosoma brucei , is an infectious flagellated protozoan responsible for nagana in cattle and human sleeping sickness. It has a biphasic life cycle in the insect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (19): 4527–4536.
Published: 1 September 2004
... of these cells, suggesting that Dab1 makes Crk a limiting factor for migration. The Dock1-Dab1 association is indirect and requires CrkII. In organisms such as Drosophila melanogaster and Caenorhabditis elegans , signaling complexes, which contain Crk and Dock1 family members are conserved and act through Rac...